Basic Information

Gene Symbol
E2F8_1
Assembly
None
Location
chr4:1102978-1110204[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 3.9e-17 9.9e-14 50.3 0.1 3 65 71 137 69 137 0.94
2 3 5.9e-14 1.5e-10 40.2 0.1 5 64 197 269 193 270 0.81
3 3 0.82 2.1e+03 -1.9 0.1 2 22 470 489 469 507 0.61

Sequence Information

Coding Sequence
ATGGACGGGCCAGAATTTTGCAGTCCTCCTAAAAGGATAATACTTGGCAATCTGAATCAAAACGGAGGTTCGCCTGTCTCGCCTATGGCAAATTTGAAGTTACTAACTAAAGTCGCTACTAGTCGCTTTTCTGTCGGAGAAAATACGGAATGTGAGGTACCTTTGGAAAATCGTGATTTAAAAATTGATAGCAAACCATCCAGAAGATTGAGATCACTTAGTTTCATCTGTAAAAAGTTTCTTCTTTTGTATAAGTTAGACATACCTGTGGGAGATAGTCAGCAGATATCATTAGGAAATTTGGCTTTGTCGCTTGGTATTGAAAAAAGAAGGGTGTATGATATAATAAATGTAGTTTCTAGTCTTCATATGGCTGTTAAGGTGTGTAAGGACAAATACAATTGGTATGGGTATCAAAATTTAACACGACTATTGACGAAGTTAAAGGCATATGCATTGATTAATAAGTTCGATGAGCAGATCAAAGCTGTTCTTCAAAATCAATTTACACTATCTGAATCCAAAGAATCTGATTCTCCTTATATAAAGATTACTAGAGGTGATCGTTCCGTTTTTGAGGAAAATCGGATTGGTATACTCTGTCAGAAGTTCATCATGCTCTTCCTTGTCTGTAATCATGATGTTGCTTTAAACATGTGCACCATTTCTAAGCTCATACTCACTGGAGATGTCCAGGAAAAAACTGGCATGCGAAGACTATATGATATAGCCAATGTTTTGGAGGCTTTAGCTCTCATTAAACGATACCATTACAAAATTATGAAGAAGCCTGCTTTTAAATATTGCGGCCCTATAATAAATATTGATCGTACAAACTGTGAGAAGCTGATGCCGGAAAAGTTACCTTGTGTGGCGGTTTATGAAACAAGTGATCAGGGTGACACTAATTCAGATTCTTCACTAGACTTTCTACCAACGGGTTCAAAACTAGATTCAATTTTGGAAGTTGTATGCACGGAGATTGAAGAAGAAAACAGCCGAACATTTTCCTCGCCAATTAACACCGTTAAAAGAAAATCTACGGTCACGGACCGGATCCATTGTAACGCCAAGAAACAATTATTTCCATCACCGTTTGTTATGAAATCTTTGGATACTGTTAATACATTTATTAAGGCCCCAAAACATTCTTTTCGATTACAATGCAATGAATTACAAATTAAAGAGACCAATACAATAACACTACAAAATAATAATAATAATGAGGTTGGTGTGGAAGGGCAGCAGCCCATGATCAATGGAGCTCGCAGATATTCCAATTTTAGAACTAGTTTCAGTACATTGGCACGTTTAGAAGAGAATTGCGTGAGTAATGCACCTTCAGAAGACATTTTTCAGACGGGGGCAGAATGGTCTCAGCCATCTTTCTCCTCCAATAATTTATCAAATGAATCTTTAAAGCTGATCACTAGTGACATGAAAACAACAGAAAGACAAAATAATAATAAATTAGTGTTACATAAATTATCTAATCTTGCCCAGACGATTGCGCCAACCAAAATTAAAGTAATCCGTCCAACGAAAATATCCGATATTCAAAATGGTGGTGTTTATAAAGTACTAAAAAAAGGCAATACTGTGCAATTGTATGCATTATGA
Protein Sequence
MDGPEFCSPPKRIILGNLNQNGGSPVSPMANLKLLTKVATSRFSVGENTECEVPLENRDLKIDSKPSRRLRSLSFICKKFLLLYKLDIPVGDSQQISLGNLALSLGIEKRRVYDIINVVSSLHMAVKVCKDKYNWYGYQNLTRLLTKLKAYALINKFDEQIKAVLQNQFTLSESKESDSPYIKITRGDRSVFEENRIGILCQKFIMLFLVCNHDVALNMCTISKLILTGDVQEKTGMRRLYDIANVLEALALIKRYHYKIMKKPAFKYCGPIINIDRTNCEKLMPEKLPCVAVYETSDQGDTNSDSSLDFLPTGSKLDSILEVVCTEIEEENSRTFSSPINTVKRKSTVTDRIHCNAKKQLFPSPFVMKSLDTVNTFIKAPKHSFRLQCNELQIKETNTITLQNNNNNEVGVEGQQPMINGARRYSNFRTSFSTLARLEENCVSNAPSEDIFQTGAEWSQPSFSSNNLSNESLKLITSDMKTTERQNNNKLVLHKLSNLAQTIAPTKIKVIRPTKISDIQNGGVYKVLKKGNTVQLYAL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01478665; iTF_01301429;
90% Identity
-
80% Identity
-