Basic Information

Gene Symbol
E2f8
Assembly
GCA_011037195.1
Location
JAAEAF010002677.1:60955-69590[-]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 8.2e-18 3.1e-13 51.2 0.1 3 65 71 137 69 137 0.94
2 3 8.6e-12 3.2e-07 32.0 0.1 21 64 161 216 141 217 0.72
3 3 0.51 1.9e+04 -2.5 0.1 48 60 423 435 421 450 0.63

Sequence Information

Coding Sequence
ATGGACGGGCCAGAATTTTGCAGTCCTCCCAAAAGGATAATACTTGGTAATCTGAATCAAAACGGAGGTTCGCCTGTCTCGCCTATGGCAAATTTGAAGTTACTAACTAAAGTCGCTACTAGTCACTTTTCTGTCGAAGAAAATACAGAGTATGAAGTACCTTTGGAAAACCGTGATTTAAAAATTGATAGCAAACCATCAAGAAGATTGAGATCACTTAGCTTCATCTGTAAAAAattccttGTTTTGTATAAGTTAGACATTCCTATGGGAGATAGTCAGCAGATATCATTAGGAAATTTGGCTTTGTCGCTTGGTATTGAAAAAAGAAGggtatatgatataataaatgtaGTTTCTAGTCTTCATATGGCTGTTAAGgTATGTAAGGACAAATACAATTGGTATGGGAATCAAAATTTAACGCGGCTATTGACGCAGTTAAAAGCTTATGCTTTGATTAATAAGTTCGATGAGCaggaTGTTGCTTTAAACATGTGCACCATTTCAAAGCTCATACTCACTGGAGATGTCCAGGAAAAAACTGGCATGCGAAGATTATACGACATAGCCAATGTTTTGGAGGCTTTAGATCTCATTAAACGATAccattataaaattatgaagaaacCTGCTTTTAAATATTGCGGCCCTGTAATAAATATCGATCGTACAAactGTGAGAAGCTGATGCCGGAAAAGTTACCTTGTATGGCGGTTTGTGAAACAAGTGATCAGGGTGACACCAATTCAGATTCTTCTCTAGACTGCCTACCGACGGGATCAAAACTAGACTCCATATTGGAAGTTGTATGTACAGAGATTGAAGAAGAAAACAGTCGAACATTTTCCTCGCCAGTTAACAccgttaaaagaaaatctatggtCACGGACCGGATCCATTGTAACGCCAAGAAACAATTATTTCCTTCACCATTTGTTATGAAATCTGTGGATActgttaatacatttattaaggCGCCAAAACATTCTTTTCGATTAGAATGCAATGAATTACAAATTAAAGAGACCAATACAATAAcactacaaaataataataataatgaggttCCTGTAGCATCAGTTTTAAAAATGCAGCCCATGATAAATGGAGATCGCAGATATTCCAATTTTAGAACTAGTTTCAGTACATTGGCAGCTCGATTAGAAGAGAATTGCGCGAATAATGCAACTTTAGGAGATGACATTCTGCAGACGAGTACAGAATGGTCTCAGCACTCTTTCTCCTCCAATAATTTATCAAATGAATCTTTAAAGTTAATGTCTAGAGACGCGAAAACAACAGTAAtacaaaatagtaataaattattgttaaataaattatctaatctTGCCCAGTCGATTGCGCccacaaaaattaaagtaatcCGTCCAACGAAAATATCCGATATTCAAAATGGTGGTGTTTATAAAGTACTAAAAAAAGGCAATACTGTGCAATTGTATgcattatga
Protein Sequence
MDGPEFCSPPKRIILGNLNQNGGSPVSPMANLKLLTKVATSHFSVEENTEYEVPLENRDLKIDSKPSRRLRSLSFICKKFLVLYKLDIPMGDSQQISLGNLALSLGIEKRRVYDIINVVSSLHMAVKVCKDKYNWYGNQNLTRLLTQLKAYALINKFDEQDVALNMCTISKLILTGDVQEKTGMRRLYDIANVLEALDLIKRYHYKIMKKPAFKYCGPVINIDRTNCEKLMPEKLPCMAVCETSDQGDTNSDSSLDCLPTGSKLDSILEVVCTEIEEENSRTFSSPVNTVKRKSMVTDRIHCNAKKQLFPSPFVMKSVDTVNTFIKAPKHSFRLECNELQIKETNTITLQNNNNNEVPVASVLKMQPMINGDRRYSNFRTSFSTLAARLEENCANNATLGDDILQTSTEWSQHSFSSNNLSNESLKLMSRDAKTTVIQNSNKLLLNKLSNLAQSIAPTKIKVIRPTKISDIQNGGVYKVLKKGNTVQLYAL*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01479236;
90% Identity
-
80% Identity
-