Basic Information

Gene Symbol
FOXP1
Assembly
GCA_036026315.1
Location
JAYRCB010000072.1:10183-26649[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 1 1e+03 0.4 0.6 21 54 183 216 175 234 0.84
2 3 2e-29 2e-26 92.4 0.3 2 81 611 684 610 691 0.94
3 3 2.2e-06 0.0023 18.6 0.0 47 82 724 754 719 759 0.86

Sequence Information

Coding Sequence
ATGAATGGACGACAGCAGGACGTCCCGGTGAGAAGTACCACGTACAAGTGCCAAAGGGTCAGCACACTTTTCGCAGCGttgaagcagcagcagcagcagcagcagcagcagcagcaacaacagcatcTTCAGTCAAGGGACTCGTCCCACAACAGAGAAAGAGCGATAACGCGTGGGCGCGAGAGGGTCAGCAGCAACAGCACAGCCAGTGGAGCCGACGGGGAGCAGCAACAAGAGCTCACCATCGAGTACCAAGGCAATGGGAAGCTCAGTCCTACTGGGCACTCACTGACATCTGCACCGATGACCCAGCAAAAGCAGCCATTCATCACGCAACAGTCCCAGCAGCCGAGTTCCGGGGCCCCAGGGCCCCAACCAAGTCCTCATCAGAGTCCTCAGGCACCCCAAAGAGGCTCACCGCCAAATCCTACGCAGGGCCCGCCCCCAGGAGGCCCCCCAGGGGGTGGTCCACCCTCGCAGACAACGTCGCAGATGATGCTCAGCCCGGCGAGTGGCTTGCATCAGATGCAGCAACTTCTACAGCAGCACATTCTCAGTCCAAGTCAGCTGCAGTCATTCATGCAGCAACACACGTTGTACttgcaacagcagcagcagcagcatcaccAGGACTCCTCAGAACATGCGGCTAACCAGGAACGATTCGGTTACTTTTCATCTCTGAAAAACCACCAACATCAACTGGCTGAACTCGGCCGCAAGCAGCTCGAGCAGGCTATGCAGCAGCTGCAGGAACAGCTGCAGCTCAACCTGATCCAACAGACGCATCTACTGCAGACAGCCGACAAGAAGAAAGCCTCGGCGCCGCTCCAGCAACTTGCGCTCCAGCAACAGCAATTGATACAGCAGCTTCAGATCACCCAGAGGCAGTATCTACTTCAGCAAGGCTTGGGTCTCCAGGGTCACAATCACTCCTCAGGCCTCCAGCCAGGGGACTCTCTGCCGGCATGGAAGACGACGGACGCCTCGGACGGTCCGGAAACGCACCAGAATTCGAACGCGCTGAAATCCTCGACGGGATTGAACGGTATTTTAAATTCGATAGTTTCCGGCCGACGGACGGAACTGAATGGCGGCTCCGGCTTGGACGAGAAACCACTGGATGTCTCCTGCAACGATAAGGCTCATCCGCTCTACGGTCACGGAGTTTGCAAGTGGCCCGGCTGTGAAGTTATTTGCGATGACTATCAAGCATTCCTCAAGCACCTCAATACCGAACACACCCTGGACGACAGATCGACAGCACAGGCTAGAGTGCAAATGCAGGTTGTCTCGCAGTTGGAAATACAGTTGCAGAAAGAACGCGACCGGCTGACTGCAATGATGCACCATCTTCACGTGGCCAAGCAAATGGCCTCGCCCGAACCGCCAAAATCCTCGGAATCCTCGacgGGATCGAGTTTACCGAAGCTGCATCTCTCCTCGGCCTTGATGAGCCAACCACCATCGAACTTTGGCGTTTCCCAGGTCTCGCCAGTCTCGATGTCGGCCCTCGTTTCTGCCGTGAGGTCACCGGCGGGAGGACAACTTCCGCCATCAGCGGGTGGTGCACCGATGCCGCCGATACCGAACCTCTCGAACATGTCAGGCATACCACCGATGCCAAACATGCCCGGCAGCATGCCGAGTATGCCGAGTATGCCGAATATGCCAAGTATGCCCAGTATGGCTGGACCCATAAGAAGGCGAATAAGCGATAAGTCGGCACTCTCTCTGGCTGGAGGGCTGCCCTACATGCTGGAGCGTGCTGGTCTTGACGTCCAACAAGAGATACAACGGAATCGGGAATTTTACAAGAATGCTGATGTACGGCCACCCTTCACATACGCTTCATTAATTCGACAGTCGATAATCGAGTCGCCGGATAAGCAACTGACGTTGAACGAAATCTACAACTGGTTCCAGAATACATTCTGCTACTTCAGACGTAACGCAGCCACGTGGAAGaaCGCAGTGCGACACAACCTGTCTCTCCACAAATGTTTCATGCGAGTTGAAAACGTGAAAGGGGCCGTTTGGACGGTGGACGAAGTGGAGTTTTACAAGAGACGTCCTCAACGCGCTTGCAGCACGACTGGGGTAGCGGGGGGCTGCGTTGTACCAGTTGATCCAGTTGATCCAGTTGATCCAGTTGATCCAGTTGAACAGAGCCAGAACGCGATCCGCACCAATCTATCATTGCACAAGTGTTTTGTGCGCTATGAGGACGACTTCGGGTCATTCTGGATGGTGGACGACGCCGAGTTTGTAAAGCGGCGGCATCTATCCCGCGGCCGCCCCAGGAAATATGACCCAACCCCATCACCCACTCCACCCCACCTCTCCGCACAGGGTGTCCCGTCCAAGAGCCCCACGCTAACCCACAGTCCGACGATGTATGGGGATGCACTGAACAGCAACCTCCAGTATTTCCAGGCTGCGCTCGGTGAGTCGAACATGGGCTTCCTGAACAACTCGATGTGCACGTCGACAGCGACAAGCCCTGACAAGGAGCACGTGATGGCCCATAGCGATCTGATGTCACCTTTGGATGAACCGGCGGTGCATATAAAGCAAGAGGGTCAGAGTCCCGAGGGAGGCAAGCTGTCCAGACTAATAAAGCGTGAACTCCTGGATGCACCTACGGAacaggagcaggaggaggacCAGGTTGACGAGAGGGATTACCCGGAGAGTCACGGACATGATTCCGGTCAAGACGAAGATATGGCCGAGGACCTCTCGATGGCACCCGACATCATGACGCCGGATGATCAGATCGAGGCGTAG
Protein Sequence
MNGRQQDVPVRSTTYKCQRVSTLFAALKQQQQQQQQQQQQQHLQSRDSSHNRERAITRGRERVSSNSTASGADGEQQQELTIEYQGNGKLSPTGHSLTSAPMTQQKQPFITQQSQQPSSGAPGPQPSPHQSPQAPQRGSPPNPTQGPPPGGPPGGGPPSQTTSQMMLSPASGLHQMQQLLQQHILSPSQLQSFMQQHTLYLQQQQQQHHQDSSEHAANQERFGYFSSLKNHQHQLAELGRKQLEQAMQQLQEQLQLNLIQQTHLLQTADKKKASAPLQQLALQQQQLIQQLQITQRQYLLQQGLGLQGHNHSSGLQPGDSLPAWKTTDASDGPETHQNSNALKSSTGLNGILNSIVSGRRTELNGGSGLDEKPLDVSCNDKAHPLYGHGVCKWPGCEVICDDYQAFLKHLNTEHTLDDRSTAQARVQMQVVSQLEIQLQKERDRLTAMMHHLHVAKQMASPEPPKSSESSTGSSLPKLHLSSALMSQPPSNFGVSQVSPVSMSALVSAVRSPAGGQLPPSAGGAPMPPIPNLSNMSGIPPMPNMPGSMPSMPSMPNMPSMPSMAGPIRRRISDKSALSLAGGLPYMLERAGLDVQQEIQRNREFYKNADVRPPFTYASLIRQSIIESPDKQLTLNEIYNWFQNTFCYFRRNAATWKNAVRHNLSLHKCFMRVENVKGAVWTVDEVEFYKRRPQRACSTTGVAGGCVVPVDPVDPVDPVDPVEQSQNAIRTNLSLHKCFVRYEDDFGSFWMVDDAEFVKRRHLSRGRPRKYDPTPSPTPPHLSAQGVPSKSPTLTHSPTMYGDALNSNLQYFQAALGESNMGFLNNSMCTSTATSPDKEHVMAHSDLMSPLDEPAVHIKQEGQSPEGGKLSRLIKRELLDAPTEQEQEEDQVDERDYPESHGHDSGQDEDMAEDLSMAPDIMTPDDQIEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01411297;
90% Identity
iTF_01475263;
80% Identity
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