Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.038 3.7e+02 3.4 0.2 19 52 12 45 4 46 0.81

2 7 0.0018 18 7.6 0.0 22 52 43 73 39 74 0.87

3 7 0.014 1.3e+02 4.8 0.0 21 51 70 100 68 101 0.87

4 7 0.00095 9.2 8.5 0.1 21 46 98 123 95 131 0.89

5 7 0.0026 25 7.1 0.0 21 51 130 160 125 161 0.86

6 7 0.0018 18 7.6 0.0 21 52 158 189 156 190 0.88

7 7 0.00087 8.4 8.6 0.3 21 46 186 211 184 216 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.038	3.7e+02	3.4	0.2	19	52	12	45	4	46	0.81
2	7	0.0018	18	7.6	0.0	22	52	43	73	39	74	0.87
3	7	0.014	1.3e+02	4.8	0.0	21	51	70	100	68	101	0.87
4	7	0.00095	9.2	8.5	0.1	21	46	98	123	95	131	0.89
5	7	0.0026	25	7.1	0.0	21	51	130	160	125	161	0.86
6	7	0.0018	18	7.6	0.0	21	52	158	189	156	190	0.88
7	7	0.00087	8.4	8.6	0.3	21	46	186	211	184	216	0.90

Coding Sequence: ATGGAAATGTCAGAACTTCCAGAAGCAAAGGTATCCAGCTGCAGTAAACCTTTTCAGTGTTCGGAATGTAACAAACAGTTCCGGCAGCTGAGCACATTGACAAACCATATGAAAATACACACTGGTGATAAACCTTACAAATGCACAATATGCTCGAAAGAATTTCGCCAAACTACGACCCTGTCCAATCATATAAAAATTCACACGGGGGAGAAGCCATTTCATTGCACTTACTGCGGCAAACAGTTCCGTCAATTGAGTACACTATCTAATCATCTTAAAATCCATACTGGAGAGAAACCCTACGAATGCTCAGTCTGTGGAAAACAGTTCCGGCAGAGCAGTACGCTGAACAGCCACATCAGGATTCACTCGGACGACAAGTATTCTGTGAAACCCTTCAAATGCAGCGTCTGCCCCAAGGAATTCCGCCAGACTACAACCCTGTCAAACCACCTGAAAATTCACACCGGTGAAAAACCCTACATTTGTACATATTGCAATAAAAGTTTTAGACAGACAGGAACGCTCTCAAACCACTTGAAAATTCATACCGGAGAAAAACCTTACGAATGCTCTGTGTGCCGAAAACAGTTTCGACAGTCCAGTACGCTGAATTCTCACATTCGAATCCACGCGGAGGACAAGATATGTAAAACATCTTCATCTCCTCTGCCGACAACAGTGACAACGATTACCATGAAGCTCGACGAAATGAAGCCTCCGCTTTACACCATCATTTAG
Protein Sequence: MEMSELPEAKVSSCSKPFQCSECNKQFRQLSTLTNHMKIHTGDKPYKCTICSKEFRQTTTLSNHIKIHTGEKPFHCTYCGKQFRQLSTLSNHLKIHTGEKPYECSVCGKQFRQSSTLNSHIRIHSDDKYSVKPFKCSVCPKEFRQTTTLSNHLKIHTGEKPYICTYCNKSFRQTGTLSNHLKIHTGEKPYECSVCRKQFRQSSTLNSHIRIHAEDKICKTSSSPLPTTVTTITMKLDEMKPPLYTII

Sequence clustering based on sequence similarity using MMseqs2