Tcin017499.1
Basic Information
- Insect
- Tolmerus cingulatus
- Gene Symbol
- egg
- Assembly
- GCA_959613345.1
- Location
- OY390708.1:10963912-10969303[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 3.1 2.1e+04 -3.4 0.0 41 61 253 273 253 276 0.84 2 2 6e-15 4.1e-11 43.7 0.1 5 70 808 866 805 872 0.90
Sequence Information
- Coding Sequence
- ATGGATACTAAACCGAAATTCGGTACGGAGGCAGAGAAAAAAGTGGCCGAGGAGGTTGCTTCAGGGAGCAAAGAAAGTGAGACTCCGGCAAGTAAGGGCGAGTCTTCAGCCAAGGAAGCTGCGGAAGAAGTAATTGACCTGAATAGTTCAATTGAGTCCGATCTGCAAGATAAGCACGAAGCGGGCGAAAAAATAGTCCCTAAAGAAGCAAGTGAAGAACTTCAAAAGGAAATGAAGGCGCCTACTGGAGATGGCGGTGATGACATGGATGTCGATGAAACGATCACAAATCGAGAACCAGAAATCATAAGACCTCCTGCGAAAACGCCCGATCCAGAATGTCTCGGTGATTCCAAACCGAGCTGCTCAGAAAAAGAAATCACGGACATTACAGAGAACAGTGAAAAAGACGTCCTAGGATTAGTCGAAGATGAGGAACTGACGCTCATTCCGATTGGTATTCGAGAAGACGATGAGGAGATGGAGCCCGAGGGACACGAGTCCTCGGAAGAACCCTCAACCCCTGTTGAAATGTTCGACGTGGAACCTGAGAAGGGGATTGACGATCTCAGCGCGCGAGAATCTCCAATTGAAAAAATGGACTTTGATTGTATTGAAGAGAAAACGGGCGAGAAAAGCGttgaaaacaaagaaaagGATGTAGCACCAGAAGAAATCCCCATGGAAGCTTTTGAGCTACCCGAAATAGATAAAATAGCATTGGTGGAATGCACTGATATGGGAAGGAtaataagtgaaaaaataagacaGGTAATGGATGAGgaagaatatatttttcacgGTAGGGAATGCGTCAATTACGAATGCGCGCAATCCAGCAAGGCATTTTACAAAGCCCCAATATTTGccttgaatttttataaggCTTCTCGGAAACTTAACAAGATCCAGTTTGTTTGTGAAGATTGTTACAACAAATGTATCAGCAAATACGAGGAACTGACCGGGGCTCTCGTGAGTCATCAGCCGCTTTTGTTGCAAAATATTCCGAAGAGGCAAGAATTTGTAGAGATTTTGGACAGCAGTGATGAAGAGGATGATAAAGGAAAAGACCAAAAGGATGAAGGACCTGGAGACTTTCCGAAGGAAACCATTGACTTTCTCTCAGAAGAGCTTGACGCAACTATTAGCAGCGTTTTAAACCGCGTGCAAATAGAAAATCAAGTGAATTGGACAAAAAGCATtctcttaaataaaattaaaaaattaaaagAGGATTCTGATTTTATATCAGAAGGTCTGAAATCTCTTCAAAAGAGCGCTGATACTATGCACAACTCGCTTTACAAATgccctaaaataaaaataaaagaactgaTGCCACTTGATTTGAATACAGGAAGACCCTTCCAGACTGAAAATGAGATGACGatACCACCAATCGGGGATTTGCCTTTTCCGCCTATTGAAATTAATGGCTCATATTTTGCCGTCAAGAACAAAGTAATAGCCAGCTGGTTACCTTGCAAAGCTGTTGAGTTTATAGATGCATCGGTTACTATGTCGAAAACGGTTAAGTACTACAGAGTAAAGTTTCATAAGATGAAAATTCCAACCGTTAAGTGTGTGCCTGCAAAGCATATGGCTTACGGGGATCCCCCAAAAGTTCGATTGCAAATAGgaaCTCGAATTATCGCTCTTTTTGACGGTTCTACTCTCAGTAAGGACAAACCTCCCAGTACTAAGAGCGCTTTTTACCCAGGAATTGTTGCGGAACCGTTGCAGACTTACAATAAATACAGatACTTGATATTTTTTGATGATGGATACGCGCAGTACGTTTGTCACAAAGATGTGCGAGTTGTCTGTCAagcttcagaaaatgtttggGAAGACGTGCATTCATCTTCAAGAGAATTTATTCATAACTACATTACCCAGTATCAGAAAAATCGTCCAATGGTGCAGGTTAAAAAAGGCCAAAGCATGATAACTGAATCTAATGgAAAATGGTTATATGCTAAAGCTATTGACATTGATGCAAGTTTAGTACAAATGCTGTTCGATGGCCAAAATCGTACAGAATGGATTTACAGAGGATCTACTAGACTTGGTCCACTATTCAGGGAGAAGCAAACAAAACGGTCTCTACAAATATCTCAGCTACCTAGAcGAAGTGAACCGTACGTTCGATACTGGGAGGATGAGGAAGCTAATAAGAACGATAACAACGCTGAAAAGCAAATTCGCGCAGTTGCAAAAAAGAGCACCACTTCGAAGAACGACTATCAGCAAcctataaaacatttaaataactCTACTATATTTCTCGATGATAACAAGCCTAAGGGAAAGGTGGTTTATTACACAGCAAAAAAGAACATGCCACCTAAGCCTTTTGTTCCTCATGAATGCAGCCCTAGATGTTTGTTTAACATATCTCATAACTTGAGCAGTTACAGTCCATTAGCAAAACCACTACTTTCTGGCTGGGAGcgtcaaatatttaaaaataaattaaaaaaatttgtcgtATATCGGACTCCATGTGGACGTCGCATAAGAAATATGGAGGAgttgcataaatatttaagaaaaacaaaaaatagtttgaatgttgacaattttgattttgatattCTTATTCATTGTCTGGCGGAGTTTGTAATTGAAAGTAGTATTGTTCAGAAACATGATCTTTCGGAGGGGAAAGAAAACATGATAATTCCGTGTATTAACTACTATGACAATACAATGCCTCCTGAATGCACTTATTCCACTAAACGAATACCAACGGAAGGCGTGTTTTTGAACTTAGATCCAGAATTTTTAACTGGATGTGATTGCGAAGATGATTGTCTTGACAAATCAAAATGCAGTTGCTGGCAGCTTACTATTCAAGGAGCTAGATTTGGTAATCCAAATACGCCAGCGGAAAGCGTCGGATACCAGTATAAAAGATTGCCTGAGGCAGTTCCCACCGGTATATATGAATGCAATGTTAAatGTAAGTGTTCGAAGAATTGTCTTAATCGCGTTGTACAGCACCCACTACAGATGAAGCTGCAAGTctttaaaacttcaaatagAGGCTGGGGACTTCGCTGTATTAATGATGTTCCGAAAGGTAGTTTTATCTGCATCTATGCAGGGCATTTGCTTACTGAACAGAACGCCAATGAAggTGGAGCGAATTCTGGTGATGAATACTTTGCAGAATTGGATTATATTGAAGTGGTTGAAAGGCTCAAAGAAGGGTATGAATCTGATGTCCAAGAAGAAGTTGAGGAAAGTGAGGAAGAGTATGAGGAACCCGCCCAAGAAAATGACTCAGATGAAGACTTTCGGTTAAATGTCcatgtaaacaaaaatcttcCAATCAACACAAGATTAAGGTCTCGCCGTAGCACAAAAGAATATTCGAAAAAGAgtaatgatgatgatgaggaAGAGGAGCGCCAAGTTATTAACTTTGAACCAAATACTTCTCTTGACAATGAGGAGAGTACGAATACTAAGTATAGGTCTATCAGAAGATATTTCGGTAAAAATGAGTTTTGTTATGTTATGGATGCCAAAAAGACTGGCAATATTGGACGATATTTCAATCATTCTTGTTCGCCGAATCTATTTgtccaaaatgtttttgtcGACACTCATGATCTTCGCTTCCCGTGGGTAGCATTCTTTGCTTTAACTCATATTAGAGCGGGGTCTGAGTTGACTTGGAATTATAATTACGAAGTCGGCATCGTACCTGGAAAGGTTTTATTCTGTGAATGTGGCGCTCCAAATTGTCGTGGGCGTttgctataa
- Protein Sequence
- MDTKPKFGTEAEKKVAEEVASGSKESETPASKGESSAKEAAEEVIDLNSSIESDLQDKHEAGEKIVPKEASEELQKEMKAPTGDGGDDMDVDETITNREPEIIRPPAKTPDPECLGDSKPSCSEKEITDITENSEKDVLGLVEDEELTLIPIGIREDDEEMEPEGHESSEEPSTPVEMFDVEPEKGIDDLSARESPIEKMDFDCIEEKTGEKSVENKEKDVAPEEIPMEAFELPEIDKIALVECTDMGRIISEKIRQVMDEEEYIFHGRECVNYECAQSSKAFYKAPIFALNFYKASRKLNKIQFVCEDCYNKCISKYEELTGALVSHQPLLLQNIPKRQEFVEILDSSDEEDDKGKDQKDEGPGDFPKETIDFLSEELDATISSVLNRVQIENQVNWTKSILLNKIKKLKEDSDFISEGLKSLQKSADTMHNSLYKCPKIKIKELMPLDLNTGRPFQTENEMTIPPIGDLPFPPIEINGSYFAVKNKVIASWLPCKAVEFIDASVTMSKTVKYYRVKFHKMKIPTVKCVPAKHMAYGDPPKVRLQIGTRIIALFDGSTLSKDKPPSTKSAFYPGIVAEPLQTYNKYRYLIFFDDGYAQYVCHKDVRVVCQASENVWEDVHSSSREFIHNYITQYQKNRPMVQVKKGQSMITESNGKWLYAKAIDIDASLVQMLFDGQNRTEWIYRGSTRLGPLFREKQTKRSLQISQLPRRSEPYVRYWEDEEANKNDNNAEKQIRAVAKKSTTSKNDYQQPIKHLNNSTIFLDDNKPKGKVVYYTAKKNMPPKPFVPHECSPRCLFNISHNLSSYSPLAKPLLSGWERQIFKNKLKKFVVYRTPCGRRIRNMEELHKYLRKTKNSLNVDNFDFDILIHCLAEFVIESSIVQKHDLSEGKENMIIPCINYYDNTMPPECTYSTKRIPTEGVFLNLDPEFLTGCDCEDDCLDKSKCSCWQLTIQGARFGNPNTPAESVGYQYKRLPEAVPTGIYECNVKCKCSKNCLNRVVQHPLQMKLQVFKTSNRGWGLRCINDVPKGSFICIYAGHLLTEQNANEGGANSGDEYFAELDYIEVVERLKEGYESDVQEEVEESEEEYEEPAQENDSDEDFRLNVHVNKNLPINTRLRSRRSTKEYSKKSNDDDEEEERQVINFEPNTSLDNEESTNTKYRSIRRYFGKNEFCYVMDAKKTGNIGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFALTHIRAGSELTWNYNYEVGIVPGKVLFCECGAPNCRGRLL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00628369;
- 90% Identity
- -
- 80% Identity
- -