Tunc000371.1
Basic Information
- Insect
- Tipula unca
- Gene Symbol
- MBD2
- Assembly
- GCA_951394425.1
- Location
- OX596380.1:4442792-4444099[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 4.7e-22 4.7e-18 66.0 0.0 1 58 5 62 5 76 0.90 2 2 0.00033 3.3 8.8 0.0 29 74 146 199 125 202 0.83
Sequence Information
- Coding Sequence
- ATGAATATctcaattgaaaaaaagaaaacagaCTGTATTTCATTACCGAAAGGTTGGCAAAGAGAAGAAGTACTAAGAAAAACAGGATTATCAGCTGGTAAAATAGATGTGTATTATTACAGCCCATCTGGTAAAAGAATTGAAAACAAACCCCAACTGGCACGCCATTTGGGTGATACGATGGATACATCAATATTTGATTATCAAAATGGTAAACTTGTTGGAAATCCCAATCAATCACTGTATCAGAGAAGTGGAATTAAGAAAAAGATAATAACTGGTAGTACTACTACTTGTGGTGGAATATTGACTGCTGGAAGTGGTGGTGGTGGTTCAAATCAAACAAATCTTATAGCATCCAGTGGTGGTTTACCATCTTCATCTGGATTAGCAACAGCGGCCGCATTTCGCCATCAATTTGACTATAGtcgAGGAATGAGAACAGACGCTTCTTTGGTTCCGCCTATACGACAAACGGcttcaatattcaaacaacCAGTCACTATTCATAAAAATCAAGAAGGCAAAGTAAAAATTGATCTGAAGCATGGAGTTCAAGAAAAacctaaacaattattttgggaAAAACGTTTGGAAGGTTTACGGGCATGTGATATCGATGGAACCGAGTTTGGTTCCGTAGAGCTTCCAAAAGGTTTAAAACCTGTTGGTCCAAACGTCAATGAAGGTACGTTACTACAATCAATTGCTACCGCATTACATGCGTCTTCACAACCGGTAACTGGACAAACTGCATCAAAAACTTCTTTACAAGCAAATGCTTGTGCATTTTTAAATCCTGAGCAACCATTAATGTATTCTGTAAATATCACAGATGATGATATTAAGAAACAAGAAGATCGTGTTTTATCAACAAGAAGAAAACTTCAAGATGCACTTCGTGTGTAA
- Protein Sequence
- MNISIEKKKTDCISLPKGWQREEVLRKTGLSAGKIDVYYYSPSGKRIENKPQLARHLGDTMDTSIFDYQNGKLVGNPNQSLYQRSGIKKKIITGSTTTCGGILTAGSGGGGSNQTNLIASSGGLPSSSGLATAAAFRHQFDYSRGMRTDASLVPPIRQTASIFKQPVTIHKNQEGKVKIDLKHGVQEKPKQLFWEKRLEGLRACDIDGTEFGSVELPKGLKPVGPNVNEGTLLQSIATALHASSQPVTGQTASKTSLQANACAFLNPEQPLMYSVNITDDDIKKQEDRVLSTRRKLQDALRV
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01455765; iTF_01459694; iTF_01454843; iTF_01457344;
- 90% Identity
- iTF_01457344;
- 80% Identity
- -