Basic Information

Gene Symbol
MBD2
Assembly
GCA_963932295.1
Location
OZ010737.1:195712700-195713984[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 8.5e-22 4.7e-18 65.7 0.0 1 58 5 62 5 81 0.90
2 2 0.0011 5.9 7.7 0.0 29 73 145 197 123 201 0.80

Sequence Information

Coding Sequence
ATGAATATATcaattgaaaaaaagaaaacagacTGCATTTCTTTACCAAAAGGATGGCAAAGGGAGGAAATATTGAGAAAAACTGGATTATCAGCTGGTAAAATTGATGTGTATTATTACAGCCCATCTGGTAAAAGAATTGAAAACAAACCCCAACTAGCACGCCATTTGGGTGATACAATGGATACATCAatatttgattatcaaaatggTAAACTTGTTGGAAATCCCAATCAATCTCTGTATCATAGAAGTGGAATTAGAAAAAAGATAGTTACTGGTAGTACTACTACAGGTGGTGGAATATTGACTATTGGCAGTGGTGGTGgttcaaatcaaacaaatattatacCATCTAGTGTTGGTTTACCATCCTCATCTGGATTAGCGACAGCGGCTGCATTTCGCCATCAATTTGACTATAGtcgTGGTATGAGAACAGACGCTTCTTTGGTTCCGCCTATACGGCAAACAGCTTCAATATTCAAACAGCCAGTCACGATTCATAAAAATCAAGAGGGTAAAGTTAAAACAGACCTAAAGCATGGTATACAAGAAAAACCGAAACAATTATTTTGGGAGAAGCGTTTAGAGGGTCTACGAGCTTGCGATATCGATGGGACAGAATTTGGTTCGGTAGAGCTTCCAAAAGGATTAAAACCAGTTGGTCCAAACGTGAATGAAAGTACATTGCTTCAATCGATAGCTACCGCATTGCACGCATCTACACAACCAGTAACAGGGCAGACTGCATCGAAAACTTCACTCCAAGCCAATGCATGTGCATTTCTAAATCCTGAACAACCATTAATGTATTCTGTTAATATCACAGATgaagatataaaaaaacaagagGATCGTGTTTTATCAACAAGAAGAAAACTTCAAGATGCACTTCGTATATAA
Protein Sequence
MNISIEKKKTDCISLPKGWQREEILRKTGLSAGKIDVYYYSPSGKRIENKPQLARHLGDTMDTSIFDYQNGKLVGNPNQSLYHRSGIRKKIVTGSTTTGGGILTIGSGGGSNQTNIIPSSVGLPSSSGLATAAAFRHQFDYSRGMRTDASLVPPIRQTASIFKQPVTIHKNQEGKVKTDLKHGIQEKPKQLFWEKRLEGLRACDIDGTEFGSVELPKGLKPVGPNVNESTLLQSIATALHASTQPVTGQTASKTSLQANACAFLNPEQPLMYSVNITDEDIKKQEDRVLSTRRKLQDALRI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01458390;
80% Identity
-