Thel085161.1
Basic Information
- Insect
- Tipula helvola
- Gene Symbol
- topi
- Assembly
- GCA_963556165.1
- Location
- OY744482.1:378009191-378011292[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 9 1.5e-06 0.00054 23.1 0.8 1 23 185 207 185 207 0.98 2 9 0.0014 0.52 13.7 0.7 2 23 227 249 226 249 0.94 3 9 0.0011 0.42 13.9 1.4 1 23 317 339 317 339 0.99 4 9 0.018 6.5 10.2 0.7 1 20 385 404 385 409 0.91 5 9 1.3e-06 0.00049 23.2 2.0 1 23 468 490 468 490 0.95 6 9 0.0048 1.8 12.0 1.0 1 23 496 521 496 521 0.95 7 9 0.064 24 8.4 0.7 1 23 527 549 527 549 0.89 8 9 9.1e-07 0.00034 23.7 0.2 3 23 557 577 555 577 0.98 9 9 0.00015 0.054 16.8 0.6 1 23 583 606 583 606 0.96
Sequence Information
- Coding Sequence
- ATGAACATTTTAAACagtgatttgaatgaaaatattttactcgATTTGAATAGTTTGTCACTACCGACAGATGATGAGCATGAAAATCAATTAACGGAAGAAACGAATGTAAAATTATCGAATGAATCGGATAATGTGGTCGAAGTTGCGGATGAAATTAGTTGGGATCAAATAATACAATTGGCTCAAGATAGGACAAATGATGTGTATCTGATGCCGGATGATAATAACCACCATGATATATTTACCTTGCTGAATATGGAGGGAAAAGAATTGCCTTCggaccaaacaattattattgaggtaataaattacaatgaaaatttacCAAGCGCTATTGAGGAGGGCTCAATGACGGATAAAACGATACCAAAAGAAACTAAAGTGGGACTGGcccaacaaatgaaaataaaccaaGAAGAAGCTCTTTTAAAAATGCTGAATTCACCTTGCTTTAAACAGCTTAAAGACAATAATATTAaactacaaacatttttaaaggaACAAGCCAAAATCGACTTAAAAATCCATAATAAGAAAGGTGACGGCCCATTTGAGTGTAATCTGTGTGAACGAGTATTTGTTCATGCGTCCGGCTTGAATCGTCACATGGAAAAGCATACAAGTGAATATATACCGAACtctaatataaaatatgtaccaTATCAACCGATCGTAAAGTGCAAGATATGCGGAAGAATATTCGCAAACAACCATTCGGCGTTGgatcatttgaaatttgatcaCCAAGGCGAATACCGTGaagaaattcatttttctgAACTAGAAGCCTTTGAAGATGATATCGAGCCTGAATGTAGCAGTACAACTGATAGCTATCCTGAAGATTTGCTAATCATAAACGAGCTCATAGGAAGAGAACTAACAAAATCGTATGCCGACGATCGGGCCGTTAAAATGTTCGATGTCATAATCTTAAATTGCGTTTTTCAATGTGAATTTTGTGATTATCTTTTTGGCGATGTTGCGCAACTTATGCACCATCAAAAATCGCATGATCCATTGAATGGATATGAATGCCGTTCTTGCGATATTTTCGTTGATACACTGAAAGGCATACTCTTACACTGGCAAATTGAATGTATTTATCAGAGCGATCAATTCTATGGCTCAATCAAACTTCAACGGTACTATTTATGCAATATTTGTTTCGAAACATTTAAAACGATTGACTTACTTTACAGTCACAGataTGCGAATTCACATTTATTTCCGCGTATTTGCCATGCAACTGgcaaattaaaagttatttgtgACATTTGTGGTAGTGTGCATGACACGGCCAAATCCATGGTTGATCATTACAATCAAAAACATGTAACAATTAAAAAGACTAATAAAAAAGTAAGTAAACCCGAACCTATAATTAGAAGTCGCCAATTTCTATGTGATGTATGCGGCAAATCATACACCCAATCGAGTCATTTGTGGCAACATTTAAGATTTCACCGAGGTGTTAAGCCATTTGCTTGCAGTGTTGAAGGTTGTACACGAAAATTTACAATTCGGCCAGATTTGAATGATCATATTCGAAAATGTCACACCGGCGAACGGCCCTATCAATGCCTGGTTTGTGGAAAACGTTTTCTTACTGGGTCAGTATTTTATCAACATCGACTTATACACCGTGGAGAACGCCGTTATGGATGCGAACAGTGTGGCAAAAGATTTTATCGAGCAGATGCGCTAAAAAATCATATAAGGATTCATACCGGTGAGAAACCATATCCGTGCGAGTATTGCTCGAAAGCATTTCGACAACGTGGCGATAAAGATAAACATATTCGGGCTCGTCATTAtgcttttctaaataaaaatatggttAAACCGAATGCAGTAAAATTTCCTATTGCAAACCATGTTCAAAATAAAGTTGTATATGTTGGTGATGTCGCATTTCCTCAAAGCATGTTTCAACCGATGATTCGGGAtatagactcgatcgatttgagttaa
- Protein Sequence
- MNILNSDLNENILLDLNSLSLPTDDEHENQLTEETNVKLSNESDNVVEVADEISWDQIIQLAQDRTNDVYLMPDDNNHHDIFTLLNMEGKELPSDQTIIIEVINYNENLPSAIEEGSMTDKTIPKETKVGLAQQMKINQEEALLKMLNSPCFKQLKDNNIKLQTFLKEQAKIDLKIHNKKGDGPFECNLCERVFVHASGLNRHMEKHTSEYIPNSNIKYVPYQPIVKCKICGRIFANNHSALDHLKFDHQGEYREEIHFSELEAFEDDIEPECSSTTDSYPEDLLIINELIGRELTKSYADDRAVKMFDVIILNCVFQCEFCDYLFGDVAQLMHHQKSHDPLNGYECRSCDIFVDTLKGILLHWQIECIYQSDQFYGSIKLQRYYLCNICFETFKTIDLLYSHRYANSHLFPRICHATGKLKVICDICGSVHDTAKSMVDHYNQKHVTIKKTNKKVSKPEPIIRSRQFLCDVCGKSYTQSSHLWQHLRFHRGVKPFACSVEGCTRKFTIRPDLNDHIRKCHTGERPYQCLVCGKRFLTGSVFYQHRLIHRGERRYGCEQCGKRFYRADALKNHIRIHTGEKPYPCEYCSKAFRQRGDKDKHIRARHYAFLNKNMVKPNAVKFPIANHVQNKVVYVGDVAFPQSMFQPMIRDIDSIDLS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01458921; iTF_01460593; iTF_01457850; iTF_01455152; iTF_01052583; iTF_01054673;
- 90% Identity
- iTF_01457850;
- 80% Identity
- -