Basic Information

Insect: Nephrotoma appendiculata
Gene Symbol: topi
Assembly: GCA_947310385.1
Location: OX371224.1:328256078-328258163[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 1.4e-06 0.00032 23.1 0.8 1 23 181 203 181 203 0.98

2 10 0.00057 0.13 14.9 0.7 2 23 223 245 222 245 0.95

3 10 0.0018 0.4 13.3 0.3 1 23 314 336 314 336 0.98

4 10 1.5 3.2e+02 4.2 2.6 1 20 382 401 382 406 0.80

5 10 0.026 5.7 9.7 0.1 3 23 422 443 420 443 0.94

6 10 1.3e-06 0.00029 23.2 2.0 1 23 465 487 465 487 0.95

7 10 0.0047 1 12.0 1.0 1 23 493 518 493 518 0.95

8 10 0.064 14 8.4 0.7 1 23 524 546 524 546 0.89

9 10 9e-07 0.0002 23.7 0.2 3 23 554 574 552 574 0.98

10 10 0.00014 0.032 16.8 0.6 1 23 580 603 580 603 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	1.4e-06	0.00032	23.1	0.8	1	23	181	203	181	203	0.98
2	10	0.00057	0.13	14.9	0.7	2	23	223	245	222	245	0.95
3	10	0.0018	0.4	13.3	0.3	1	23	314	336	314	336	0.98
4	10	1.5	3.2e+02	4.2	2.6	1	20	382	401	382	406	0.80
5	10	0.026	5.7	9.7	0.1	3	23	422	443	420	443	0.94
6	10	1.3e-06	0.00029	23.2	2.0	1	23	465	487	465	487	0.95
7	10	0.0047	1	12.0	1.0	1	23	493	518	493	518	0.95
8	10	0.064	14	8.4	0.7	1	23	524	546	524	546	0.89
9	10	9e-07	0.0002	23.7	0.2	3	23	554	574	552	574	0.98
10	10	0.00014	0.032	16.8	0.6	1	23	580	603	580	603	0.96

Sequence Information

Coding Sequence: ATGACCACTCCAAATGAAAATATTTTAATCGATTTGAATAGTTTGGCACTGCCTACAGACGACGAACTTGAAAATCAAGTGCCACAAGGAGAGACTAGTGTGAAGGTTACAAACGAATCACCGGACAATGTAGTTGAAGTTGCCGACGAAATTAGTTGGGATCAAATAATTCAATTGGCCCAAGATCGAACGAATGATGTGTACTTGATGCCCGATGATAACAATCATCATGATATATTCACGCTTCTGAATATGGAGGGAAAAGAATTGCCGTCGGATCAAACTATTATTATAGAGGTAATAAATTACAACGAAAGCATTCCAAATGCCGTTGACGTTGGCTCAAAACCCGATAAAAATCTAACGCAAGAAACAAAGTTAGCACAAACGCTTAAATTAAATCACGAAGAGTCTCTATTGAAAATGCTTAATTCGCCTTGTTTTAAACAGCTTAAAGACAATAATATTAAGCTGCAAACGTTTTTAAAGGACCACGCCAAAATCGACCTAAAAATTCATAATAAGAAAGGTGATGGGCCATTTGAATGCAATCTGTGTGAAAGAGTATTCGTGCACGCGTCCGGTTTAAATCGTCACATGGAAAAGCATACAAGTGAATACATCCCGAACTCGAATATAAAATATGTACCGTATCAGCCAATAATAAAGTGTAGGATATGCGGGAGAATATTCGCAAATAATCATTCGGCTTTGGACCACATGAGATTCGATCACCAAGCCGAATATCGTGAAGAAATTCACTATTCTGAGTTGGAAGCTTTTGATGATGAGGATGCTGTGCCTGAATGCAGCAGTGTACCTGACGGCTATCCAGAGGATTTGCTTCTTATGAACGAGCTGATTGGAAGAGAATTGGCGAAACCAACCACCGAAGAAATAGCCGTAAAAATGTTCGATGTTGTAGTTTTGAATTGTGTCTTTCAATGTGAATTTTGCGATTATCTGTTTGGCGACATTGCACAATTAATGCTTCATCAAAAATCACACGATCCTTTGAATGGTTATGAGTGCCGAGCGTGTGATATATTTGTCGATACCTTAAAAGGAATACTCCTACACTGGCAAATCGAATGTATTTATCAGAGCGACCAGTTTTATGGCGCCATCAAACTTCAACGGTATTATCTGTGCAATATTTGTTTCGAGACTTTTAAATCGATTGATCTACTTTATTGCCATAGATACACAAATTCTCATTTATTTCCGCGAGTTTGTCACGCTACCGGAAAACTTAAAGTTATTTGTGAGATTTGCGGCACCATTTACGAGACGGCTAAATCAATGGTTGATCATTACAATCAGAAGCATGTGACCATAAAAAAAAGTAACAAGAAAGTTAGTAAACCCGAACCGATAGTAAGAAGCCGACAATTTCTTTGTGATGTTTGTGGTAAATCATATACGCAATCGAGTCACTTGTGGCAACATTTGCGATTCCATCGAGGTGTTAAACCATTTGCATGTAGTGTCGAGGGATGCACCCGGAAATTTACAATTCGACCAGATTTAAATGATCATATTCGAAAATGTCACACTGGTGAACGACCTTATCAGTGCCTAGTGTGCGGAAAACGATTTTTGACTGGCTCAGTATTTTATCAACATCGGCTTATACACCGAGGAGAACGTCGATATGGATGCGAACAGTGTGGCAAGCGGTTTTACAGAGCAGATGCGCTAAAAAATCATATACGTATTCATACGGGCGAGAAACCATATCCATGCGAGTATTGCTCGAAAGCATTTCGACAGCGTGGCGATAAAGATAAACACATTCGGGCTCGCCACTATGCATTCCTCAACAAAAATATGGTTAAACCGAATGCGGTAAAATTTCCGATTGCGAACCATGCTCAAAACAAAGTTGTGTACGTTGGTGATGTAGCATTCCCCCAAAGCATGTTTCAACCGATGATCCGCGATATTGACTCGATTGATTTGAGTTAA
Protein Sequence: MTTPNENILIDLNSLALPTDDELENQVPQGETSVKVTNESPDNVVEVADEISWDQIIQLAQDRTNDVYLMPDDNNHHDIFTLLNMEGKELPSDQTIIIEVINYNESIPNAVDVGSKPDKNLTQETKLAQTLKLNHEESLLKMLNSPCFKQLKDNNIKLQTFLKDHAKIDLKIHNKKGDGPFECNLCERVFVHASGLNRHMEKHTSEYIPNSNIKYVPYQPIIKCRICGRIFANNHSALDHMRFDHQAEYREEIHYSELEAFDDEDAVPECSSVPDGYPEDLLLMNELIGRELAKPTTEEIAVKMFDVVVLNCVFQCEFCDYLFGDIAQLMLHQKSHDPLNGYECRACDIFVDTLKGILLHWQIECIYQSDQFYGAIKLQRYYLCNICFETFKSIDLLYCHRYTNSHLFPRVCHATGKLKVICEICGTIYETAKSMVDHYNQKHVTIKKSNKKVSKPEPIVRSRQFLCDVCGKSYTQSSHLWQHLRFHRGVKPFACSVEGCTRKFTIRPDLNDHIRKCHTGERPYQCLVCGKRFLTGSVFYQHRLIHRGERRYGCEQCGKRFYRADALKNHIRIHTGEKPYPCEYCSKAFRQRGDKDKHIRARHYAFLNKNMVKPNAVKFPIANHAQNKVVYVGDVAFPQSMFQPMIRDIDSIDLS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01456764;
90% Identity: iTF_01054673;
80% Identity: -