Thel086176.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Tipula helvola
Gene Symbol
topi
Assembly
GCA_963556165.1
Location
OY744482.1:392494910-392499156[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 26 5.5 2.1e+03 2.3 0.4 1 23 272 294 272 294 0.93
2 26 0.0019 0.69 13.3 1.0 1 23 326 348 326 348 0.99
3 26 0.0046 1.7 12.0 1.9 1 23 354 377 354 377 0.96
4 26 0.00066 0.25 14.7 0.2 1 23 383 405 383 405 0.96
5 26 3.5e-06 0.0013 21.9 1.6 1 23 411 433 411 433 0.98
6 26 0.00031 0.12 15.7 0.1 1 23 438 460 438 460 0.97
7 26 0.0017 0.63 13.4 3.6 1 23 466 488 466 488 0.97
8 26 0.018 6.9 10.1 1.2 1 16 494 509 494 510 0.92
9 26 0.0037 1.4 12.3 1.7 1 23 522 545 522 545 0.96
10 26 0.00065 0.24 14.7 0.7 1 23 603 626 603 626 0.96
11 26 0.74 2.8e+02 5.1 0.9 1 23 632 655 632 655 0.84
12 26 4.9e-05 0.018 18.2 1.8 1 23 661 683 661 683 0.98
13 26 0.00027 0.1 15.9 1.4 1 23 690 712 690 712 0.97
14 26 0.019 6.9 10.1 3.6 1 21 718 738 718 740 0.93
15 26 0.66 2.4e+02 5.3 2.8 2 23 786 808 785 809 0.92
16 26 0.25 92 6.6 0.6 2 23 812 834 811 834 0.96
17 26 0.012 4.5 10.7 3.7 1 19 897 915 897 916 0.96
18 26 9.6e-05 0.036 17.3 0.4 1 23 958 980 958 980 0.94
19 26 0.0039 1.5 12.3 0.1 1 20 984 1003 984 1004 0.96
20 26 0.024 8.9 9.8 0.5 3 23 1021 1044 1019 1044 0.86
21 26 0.032 12 9.4 0.6 2 23 1051 1072 1050 1072 0.96
22 26 0.00048 0.18 15.1 0.3 1 23 1076 1098 1076 1098 0.97
23 26 0.032 12 9.4 5.8 1 23 1104 1126 1104 1126 0.97
24 26 6.3e-05 0.024 17.9 1.2 1 23 1132 1154 1132 1154 0.99
25 26 0.00015 0.057 16.7 5.8 1 23 1160 1183 1160 1183 0.98
26 26 0.16 60 7.2 0.2 2 20 1185 1203 1185 1207 0.94

Sequence Information

Coding Sequence
ATGGACAAACTAACTGAAGATAATGCACTCTGTTTATATAAATGCGAAAATGATGACGGAGAGGAGGAAGGAGATGTCGACCAAATCCAAGATGAAATCATCGAGGTGGATTTATACTCACTATGTCGAATATGCGGTAATATGCATGACACTTTAGTCCCGATTTATGCAGAACAGGGCCTAGAGTTGGAGcttagtacaaaaataaattattatttgccaATTGATGTTACCGAAGAGGATATTCTACCGCTTAAGGTGTGCTCCAATTGTGCTACTACAGTTACATTCTGGCATGAATTCATCGCCGAATGCTGTGAAGCTGATAAACGATTCAGTATCATGCTGCAGTCGAGTATGATGGAGGATACGAAGGCAGAAATAGTCGCTGAAAATATACAAGATGAGGTGAACGAAGTAGATAATTCTGATGAAAACCAAACCATGGATACGGAAACCCAAGGAACAGAATATTTAGAAGATGTGaatgatgaaaatattccagaaagtTTGCCGGTTGAGGAGGAGGAATTAGACGAAAAGTCAAACGAACTAGAATCAATACATGAAGAGGATACAGAAGAACAAAGCAAACCGAATAAATCACCCGACACTGCCGTAACAAGAACACGATgctcaaaaatcatttcaaccATAGAAACCTCCCCTAAAACATCATATTTTTTAGACTCTAAGGATTCAGCTAAGCTTGACGAGCTTGTTAAAAAATCTAATCGCTCCGGAAATATGCGCCTCTCGAATGAAATTCTCGATGAAATTCGCCTGAATTTAAAACTAGAAGAGGATGGTTTATACAAGTGCTATGAGTGTGAATTCGATACAAACGAACGGGACGTGATGGAAGGACATTTGAGGCAACACTTTCAgaacacattaaaaaaattgaaacagacTATGAAGCTTAAGGCGAAATTTTTTGACGAGAATAAAGTTGAAATGGACGGTAAAACGTTATACGAGTGCCCCGAGTGTAATAAACGTTTGCACGCGACAAGTACATTCCTCTGGCATATGCGGATCCATACGGGGGAAAAACCATACGTTTGCTATTTGTGCGGGAAAAAATTCCGAGTCTATCATGGGATTTCGCGACACATCAAAGAGACgcatatgaaaacaaaagacTTTGCGTGCGATATTTGTGGCCGCCTGTTCTCGAATCGGCGTAATGTCGCTGAACATCGGAATTTGCATTCAAACGAACGACCTTATACGTGTGGTACATGCGGAAAGTCATTTAAACAGCAGGCTTCTTTATTTATGCATAAACGATTACATCAACCGCATCAATATAAATGCGAGGAGTGTGGGTTAGGATTTCGGATTAAAAGTTCCCTGCTGGTGCATGCCACGGTCCATACGGGTGTCAAAGACCATGAGTGTGATATATGCCAGAAACGATTTCGTATCAAGCATGAGCTAAACCTTCATAAGCTGGTGCATACGGATTTTAAGCCATTTGCATGCGAGAAATGTGGGCAGTCGTTTAAACAGAAGCGTTACCTATTTTTTGTCTCTCGCAACGCGACCACTTCCATCCAATACAAATGCAAATTTTGTCCGATGACTTTTGTCGAAAAGTCCCGATTCAACGAACACACGAAGCTCGCGCATTCCGAACTTATATTCCATTGTGATATGTGTAACGAGCTGGTCGAACGTAACCTACTCATTTCACATATGACTGAGCACGCCCTAGAAGAGGTTCGACTAATAAACGAACAGATCGAGAGTAAGAAAATTTTGGCCACACCTGATCTCGAAACCTtacgaaaaaaatttcagttcaagtGTGATGCttgcccaaaaatgtttgtcacAAAAACTGGGTTACGGTATCACGTGAATCAGACACACAAAAAGCTGCGACGATATAAGTGTGCAGAATGTGGAAAATTATTCGGTTGTAATCGTATTCTACGGAATCATATACTGAGCGTACATTCTAACGAGCGATCGTATAATTGTGAATTATGTCCGAAATCGTTCAAAACCGATTCGTCTTATTACATTCATAGGCGGACTCATGACATGAAAATTGCCGCTTTTCCGTGTGATATATGCGGCAAGGCATTCAAGTGTGGTTCAAATTTGAAGAAACATAAATTGATTCATACTACGGATCGAAAATATATGTGCGATTTATGCtcgaaaacatttaaaacacaaaatttgttgGGCCTGCATCGGAAGTGCCATGCGACAGGCGAAGATTTTGTATGTGGTCTCTGCGTGTCAAAATTTAGACAAAGACGtTGTGATTTCGATAGCGTCAAGGAGCCGGAGAGTTTGGAAACCCTACAAACTCTAATAGCCGCCTTTCAACTGAACACCAAATGCTCGTTCAATTGTGATATAAGATTTAAGTCGTACCAAGCATTTCGAGAACATAATCTTGAGCACCACTTAAAGACGTGTATGCAGTGTGGCTTGCATTTTGCTGAGTTCGGCATGATTCAAGATCACATAAAAACGGTTCATGTATTCGGAAACGATTGGtctgaaatttgtaaattctgcGGTTTCCGAACCGACGATTTAGGCGAGCATATCCGACAACATAATTTCCTTTGGCTAGACGATATCTATTGTGCTAGTTGCGAGCTGCTGTTCGAGAATGAAATTGCAGTTGAAGTTCATTTCGCGGTGATCAGCCATGAATACCGGTATCGATGCTTTGTTTGTGGCGAAACATTTAACGATCAACACTCATATCACAATCATAAATGGGGGCATACCGCATTCACAACCATGGAACTGACTTCACCCGCACCTGATCCTCAGAACAGAGTTATAACGACCGATATGAGGAAACGACATCGCTCAGAACGGCTGCACCAACCAACGACATTCGAGTGCCCAATGTGTGATCAAAAATTTGGACGCAAGTACAATATGGAAAAACATGTGGGTCTACATCGAAACGACCATCCTTGTCGAGTGTGTGGTCTTAGTTTTGTTACGGATAACGGACTCCAAAAGCATATGGGCGATTCATGCAAATCAcgtctcaaaataaaattcgaaatagCGATTGTTTGCGGAAAGAATTCATGCAACCAAAGTTTTCGGTCGCGATACGAACTCTATCAGCATGAGAAAAATGTTCATCTACAAATTCGAACCGTGAAGTGTACAGACTGCGACCTAGAATTTAAATCGACGTCAATTATGGAGACGCATCGAAAGGTGCACGCGCTCTCATTCGAGTGCCCCTTATGTGAGAAAAAATTCCCGCTTCTACATCAATTAAAGGCGCACGAAATTGTACATACAGATGACCGACCATTTGAATGCGACATATGCATGCAAAAATTTCGGCACCATAGCAATCTGTATCAGCACAAATTGAGTCATGCCAATATTCGGAAATACAAGTGCCTATACTGTGATGCCGAATTTATGCGTGCGAATACATTTCGCGAGCATATGCGAACGCACGATGGTGATCGGCCGTATCAGTGCGAGATTTGCCATAAAAAGTATACGCAATCTTGCGTCCTCAGGCGGCACATGCAATCGATGCATCGGAAGTGTGATATTTGTAAGATGGTGGTGGGGAATAAAATGAAACTTCAAGTGCATATGTGGAAAATGCATCCGCTTTCGGATACGGATGGTATGGGACAAGCAGATTATTTGGCGGAAGAGGAAGATGAATAG
Protein Sequence
MDKLTEDNALCLYKCENDDGEEEGDVDQIQDEIIEVDLYSLCRICGNMHDTLVPIYAEQGLELELSTKINYYLPIDVTEEDILPLKVCSNCATTVTFWHEFIAECCEADKRFSIMLQSSMMEDTKAEIVAENIQDEVNEVDNSDENQTMDTETQGTEYLEDVNDENIPESLPVEEEELDEKSNELESIHEEDTEEQSKPNKSPDTAVTRTRCSKIISTIETSPKTSYFLDSKDSAKLDELVKKSNRSGNMRLSNEILDEIRLNLKLEEDGLYKCYECEFDTNERDVMEGHLRQHFQNTLKKLKQTMKLKAKFFDENKVEMDGKTLYECPECNKRLHATSTFLWHMRIHTGEKPYVCYLCGKKFRVYHGISRHIKETHMKTKDFACDICGRLFSNRRNVAEHRNLHSNERPYTCGTCGKSFKQQASLFMHKRLHQPHQYKCEECGLGFRIKSSLLVHATVHTGVKDHECDICQKRFRIKHELNLHKLVHTDFKPFACEKCGQSFKQKRYLFFVSRNATTSIQYKCKFCPMTFVEKSRFNEHTKLAHSELIFHCDMCNELVERNLLISHMTEHALEEVRLINEQIESKKILATPDLETLRKKFQFKCDACPKMFVTKTGLRYHVNQTHKKLRRYKCAECGKLFGCNRILRNHILSVHSNERSYNCELCPKSFKTDSSYYIHRRTHDMKIAAFPCDICGKAFKCGSNLKKHKLIHTTDRKYMCDLCSKTFKTQNLLGLHRKCHATGEDFVCGLCVSKFRQRRCDFDSVKEPESLETLQTLIAAFQLNTKCSFNCDIRFKSYQAFREHNLEHHLKTCMQCGLHFAEFGMIQDHIKTVHVFGNDWSEICKFCGFRTDDLGEHIRQHNFLWLDDIYCASCELLFENEIAVEVHFAVISHEYRYRCFVCGETFNDQHSYHNHKWGHTAFTTMELTSPAPDPQNRVITTDMRKRHRSERLHQPTTFECPMCDQKFGRKYNMEKHVGLHRNDHPCRVCGLSFVTDNGLQKHMGDSCKSRLKIKFEIAIVCGKNSCNQSFRSRYELYQHEKNVHLQIRTVKCTDCDLEFKSTSIMETHRKVHALSFECPLCEKKFPLLHQLKAHEIVHTDDRPFECDICMQKFRHHSNLYQHKLSHANIRKYKCLYCDAEFMRANTFREHMRTHDGDRPYQCEICHKKYTQSCVLRRHMQSMHRKCDICKMVVGNKMKLQVHMWKMHPLSDTDGMGQADYLAEEEDE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01458844; iTF_01460480;
90% Identity
iTF_01460480;
80% Identity
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