Basic Information

Insect: Tipula helvola
Gene Symbol: Exd2
Assembly: GCA_963556165.1
Location: OY744482.1:149164947-149181552[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 18 1.2e-05 0.0044 20.2 1.8 1 23 318 340 318 340 0.97

2 18 8.2e-06 0.0031 20.7 0.2 1 23 346 368 346 368 0.97

3 18 0.0003 0.11 15.8 0.3 1 23 374 396 374 396 0.98

4 18 2.1e-06 0.0008 22.5 2.5 1 23 402 424 402 424 0.98

5 18 5.7e-05 0.021 18.0 4.7 1 23 430 452 430 452 0.99

6 18 9.5e-06 0.0035 20.5 3.5 1 23 458 480 458 480 0.97

7 18 6.9e-07 0.00026 24.1 5.0 1 23 486 508 486 508 0.98

8 18 2e-07 7.6e-05 25.7 2.5 1 23 514 536 514 536 0.97

9 18 0.00011 0.039 17.2 6.7 1 23 542 564 542 564 0.97

10 18 4.1e-06 0.0015 21.7 5.9 1 23 570 592 570 592 0.98

11 18 4.8e-07 0.00018 24.6 3.1 1 23 598 620 598 620 0.98

12 18 9e-06 0.0033 20.6 7.7 1 23 626 648 626 648 0.98

13 18 4.9e-06 0.0018 21.4 6.7 1 23 654 676 654 676 0.98

14 18 5e-05 0.019 18.2 5.9 1 23 682 704 682 704 0.97

15 18 5.2e-05 0.019 18.2 5.0 3 23 712 733 711 733 0.96

16 18 7.5e-05 0.028 17.7 0.5 1 23 739 761 739 761 0.98

17 18 0.012 4.4 10.8 3.9 1 23 771 793 771 793 0.98

18 18 9.4e-07 0.00035 23.6 3.5 1 23 799 821 799 821 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	18	1.2e-05	0.0044	20.2	1.8	1	23	318	340	318	340	0.97
2	18	8.2e-06	0.0031	20.7	0.2	1	23	346	368	346	368	0.97
3	18	0.0003	0.11	15.8	0.3	1	23	374	396	374	396	0.98
4	18	2.1e-06	0.0008	22.5	2.5	1	23	402	424	402	424	0.98
5	18	5.7e-05	0.021	18.0	4.7	1	23	430	452	430	452	0.99
6	18	9.5e-06	0.0035	20.5	3.5	1	23	458	480	458	480	0.97
7	18	6.9e-07	0.00026	24.1	5.0	1	23	486	508	486	508	0.98
8	18	2e-07	7.6e-05	25.7	2.5	1	23	514	536	514	536	0.97
9	18	0.00011	0.039	17.2	6.7	1	23	542	564	542	564	0.97
10	18	4.1e-06	0.0015	21.7	5.9	1	23	570	592	570	592	0.98
11	18	4.8e-07	0.00018	24.6	3.1	1	23	598	620	598	620	0.98
12	18	9e-06	0.0033	20.6	7.7	1	23	626	648	626	648	0.98
13	18	4.9e-06	0.0018	21.4	6.7	1	23	654	676	654	676	0.98
14	18	5e-05	0.019	18.2	5.9	1	23	682	704	682	704	0.97
15	18	5.2e-05	0.019	18.2	5.0	3	23	712	733	711	733	0.96
16	18	7.5e-05	0.028	17.7	0.5	1	23	739	761	739	761	0.98
17	18	0.012	4.4	10.8	3.9	1	23	771	793	771	793	0.98
18	18	9.4e-07	0.00035	23.6	3.5	1	23	799	821	799	821	0.97

Sequence Information

Coding Sequence: ATGATTTTGGGCACCAGTCCACATTCGTTACCAATATCATTACCATCTGGATCATCATTGAATAATATACCATCTTCGATGGATTCTACAGCGTCGAtgcaatcaaatttaaatttaacatctcTTCACAGTAATTTGATCAATAATGATAATCATCCCAGTGCACTACAGTTACATCCACCACCACCTCAGCAACAAATGCAAATGGGTCAGGATGGATTAATTATGGATGTACGACAAGCACCAAAAGAATTGAAAGTGTTTGAATCAGCACAGTTGGAACATTTTCAACATCAACAGCAGCAACAACAGCAACAGcaacaacagcagcagcaacatCAATCTCAACAAACACAACAACAGCAACCACAGTTATCATCTCCAAGACATAGACAAGACAATCGTTCTGTTGATCATTCGATGAACAATTCTGATTCGCTTCATTTATCGCAAACTATGAACTCTGATATTCGAAATAATGAACCAATGCTAAATGCAAAAGACGCCAAGATACAtaactcaaaattaaatcttcaaaGTGCGCAACAACAATTTCCGGATCAGCAAAgcgatttaaaatcaaattcaaatcaatcacAATTAATGGATGTTAGAACAGCTGACGGTTCTATCGTTAAAATAGCTGCTGGAATTCAAGAACAAGATTTAACAATGTACAAAGTAAATATTgatgatttaaatcaatttttaacatGTCAcgaaatttttggtaaattgccCAATGATATGTTGGCTATGCCTACTGCTGGAATGTCAACTAATCCTACAAGTAGTGTGAGCACGAGTACTACAACATCAACGATCACCGATAGTCACAGAATTGATGGATGCGCAATTTCgccaaaacaagaaaataatatgGGACAAGGAGGATCAGCTTCGGGAAGTGGTTTAGATGAAGATTCTAAATCTCAACTTTCACAAGGTGTACATTCCTGTGATATATGTGGGAAAATGTTCCCATTTCGTTACCAATTAATCGTACACAGGCGTTACCATAATGAGAGAAAGCCATTTATTTGTCAAGTGTGTGGCCAAGCGTTTAACACATCTGATGAGTTGACAAAGCATGGGAAGGTACATCTCGGTGGCTCAATGTTTATATGTACTGTTTGCTTTAATGTTTTTGCTAATGATGCTAGTCTTGAACGACATATGAAACGACATTCGGCTGATAAACCATTCTCATGCGCGATTTGCCAAAAGACGTTTGCGCGCAAAGAACATCTTGAAAATCACACACGAAGTCATACAGGTGAAACACCATTTCGTTGCCAATATTGTGCTAAAACTTTCACACGTAAAGAACACATGGTAAATCACGTGCGAAAGCATACCGGAGAAACCCCATTTCGCTGtgatatttgtaaaaaatcatttactagAAAGGAACATTATATGAATCATGTTATGTGGCATACTGGTGAAACTCCTCATCAATGCACTGTTTGCGGCAAGAAATATACAAGAAAAGAACATTTGGCTAATCATATGAGATCACACACAAATGAGACACCATTCCGCTGTGAAATTTGTGGCAAGTCGTTTACTAGAAAAGAGCATTTCACTAATCACATACTATGGCACACGGGTGAGACCCCTCATCGTTgtgatttttgttcaaaaacatTTACACGAAAGGAACATCTCTTAAATCATGTACGACAGCATACTGGTGAATCTCCGCATAGGTGTGAATATTGTTCAAAATCGTTTACACGGAAAGAGCATCTCGTCAATCATATCAGACAACATACAGGCGAGACTCCATTTAAATGTACGTATTGTCCCAAGGCATTTACTCGAAAGGATCATTTGGTGAATCATGTGCGTCAACATACTGGTGAATCGCCACATAAATGTACATATTGTTCAAAGTCTTTCACACGAAAGGAACATTTAACCAATCATGTGAGACAACATACAGGAGAGCTTCCACATCGGTGTCAGTATTGTTCAAAATCTTTCACACGAAAAGAACATTTGACTAATCATGTCCGAATTCATACTGGAGATTCGCCTCACCGGTGTGATTTTTGCCAAAAAACTTTCACACGCAAAGAATATTTGACAAACCATTTGAAACAGCATAGCCAAGACAATCCAAATTGTTGCAATATCTGCTCAAAACCTTTTACACGGAAGGAACATTTAATAAATCACATGAGCCGATCACATACTGGTGAGCGTCCATTTTCCTGTGATGAATGCGGAAAATCATTTCCATTAAAAGGAAACCTATTGTTTCATCAGAGGAGTCATAATAAAGGAAGTACAGCTGAAAGGCCATTTCGTTGTGATTTATGCCCAAAGGATTTTATATGTAAAGGTCATCTGGTTTCACATCGAAGATCACACTCTGATGAAAGGCCGCATATATGTGAACATTGCGGTAAAACTTTTGTCGAGAAAGGCAATCTTTTAAGGCATATGAAAAAACATGTACTGGATACAGCTTATgctcaaattccaaaattggaGCCAGGTACACAATTTGCAGGACCAAAAGTGGAACCAGgAACCCAATTTCCGAATTTATCAGAATCAATTTCTACAGTAGTAACGTCAATGGAAACTGTGTCAAATAATACTGACGCAATAATAACATCAAATGCGTCTTTGTCGAATAATTACAATCcagtagataataaaatttcgaactcACAGCAACAGCAACAACCCGTATCTATAATTGCACATTCTCAGGATCATCAAATGAGTTCTTCAAATGATGCGAATCGGACAAGTGGTTCACTACAAATGCATCATTTAAATTCATCACAGGAACACCACGTGgtGGGCGTACCACCTCTTGATGATGCAGCTTACTTGGCCAAAGATTACGGAGTATGTGTAGCCAGCTCACTAGATTTGCGTTATGTTGCACAGCTCACTGGATTTAAACACGGTGGACTAGCCAATTTAAGTTCGAGTCTATTAAATGTTGAACTGGATAAAGATTGGCGTATTCGATGCTCAGATTGGGAGGCGCTCACACTTAATGACCGTAACTACCAAGCACCACCAGTTGCCATAGCAGCACGCTCAGGGCGACAAGAAGCGGTAACAAGGCATCAGAACGGCAGTCCAAACGAATGTGCGGCCCAAACGATTTCTGGACAACAGGATCAGCAATAA
Protein Sequence: MILGTSPHSLPISLPSGSSLNNIPSSMDSTASMQSNLNLTSLHSNLINNDNHPSALQLHPPPPQQQMQMGQDGLIMDVRQAPKELKVFESAQLEHFQHQQQQQQQQQQQQQQHQSQQTQQQQPQLSSPRHRQDNRSVDHSMNNSDSLHLSQTMNSDIRNNEPMLNAKDAKIHNSKLNLQSAQQQFPDQQSDLKSNSNQSQLMDVRTADGSIVKIAAGIQEQDLTMYKVNIDDLNQFLTCHEIFGKLPNDMLAMPTAGMSTNPTSSVSTSTTTSTITDSHRIDGCAISPKQENNMGQGGSASGSGLDEDSKSQLSQGVHSCDICGKMFPFRYQLIVHRRYHNERKPFICQVCGQAFNTSDELTKHGKVHLGGSMFICTVCFNVFANDASLERHMKRHSADKPFSCAICQKTFARKEHLENHTRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPFRCDICKKSFTRKEHYMNHVMWHTGETPHQCTVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFTRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCEYCSKSFTRKEHLVNHIRQHTGETPFKCTYCPKAFTRKDHLVNHVRQHTGESPHKCTYCSKSFTRKEHLTNHVRQHTGELPHRCQYCSKSFTRKEHLTNHVRIHTGDSPHRCDFCQKTFTRKEYLTNHLKQHSQDNPNCCNICSKPFTRKEHLINHMSRSHTGERPFSCDECGKSFPLKGNLLFHQRSHNKGSTAERPFRCDLCPKDFICKGHLVSHRRSHSDERPHICEHCGKTFVEKGNLLRHMKKHVLDTAYAQIPKLEPGTQFAGPKVEPGTQFPNLSESISTVVTSMETVSNNTDAIITSNASLSNNYNPVDNKISNSQQQQQPVSIIAHSQDHQMSSSNDANRTSGSLQMHHLNSSQEHHVVGVPPLDDAAYLAKDYGVCVASSLDLRYVAQLTGFKHGGLANLSSSLLNVELDKDWRIRCSDWEALTLNDRNYQAPPVAIAARSGRQEAVTRHQNGSPNECAAQTISGQQDQQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01457737;
90% Identity: iTF_01458833;
80% Identity: -