Tgen021549.1
Basic Information
- Insect
- Timema genevievae
- Gene Symbol
- egg
- Assembly
- GCA_902155825.1
- Location
- CABFWO010001537.1:147841-151365[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 9.7e-12 1.2e-07 33.2 0.0 5 70 564 622 560 627 0.87
Sequence Information
- Coding Sequence
- ATGGCTtctaaaccaaataataaacccGAGGAAATTGTTATAGACTCTGACGACGATtATTCTGATGATGATGTGGAAGATAATGTTTATCTTCCAAGTGATGTTATGACTTTGGTAGAAGACAATATTCAAGATATAATTGAATCTACTATGAACAAATATGATGTTAATTTTCAATTGAATAAGGGAGACAAGATCTTAGAAAAAAGAGTAGCTAAACTAGAACAAAAAACTACCGAAGTTGATGAAAACTTTAATGATATCCAAAAATCTTTGGATGAGACAATGAGCTTGCTATACAACGATTTTGCTCCTTTGATAAAAGAGTTACCACCCATAACAATTGTTGACGATGGAGTTCTTCCTATAAATGATCTAACTTCACATCATACAGCAACACTAATGAAGTATGGTTCTCATAAATCTGCTAAGAAACATTTCTCCCCTGATGATGGCAGAAGACCTTTAGGGGTGGCAATGAAGAAAGTGACCCAAGTGCGGCAGTGTTTATTAGGAAACAATACTTCTGAAACATCTGTTTCAGATGCTGAGGGAAATATTGTGCAAGAGATGGTTGTTCCAGATGTTGTGGCTTTAGAACAAGTAGATGTGACACACAAACCTTTGCCCCCTATAGGGCCAATACCTCGACCTACTCCTCAGCCAGGAGATATTGTTTATGTCATGAAACTGAGTTTTTATGGATTGTGGTCTCGTGCTAAGATTATTGAAATTCTACCTAAAggaacaaaagaaaataatgtatcatcTGAATATATTTCTGACATGTTTAAGGTCAAATTTGAATCAACATATCGTAAATCTAACCCTGTTAAAGTTGTCCAAGGGAAGCAGATGGCTTATCCAACACCTTGCCCTATGCGCTATCATGTTGGCACACGAGTAATAGCTATATTTAGTGAAGATGAACGAAGTAAGGAAAGTTTCTATGCAGGGGTCATTGCAGAACCCCCAAAGTCGATGAACAAATTCCGATATTTGGTGTTCTTCGATGATGGCTATGCCCAATATATTTCCCATGAGAAGATTCTCCTGGTCTGTGAAAGTTCTAAACAAGTATGGGAAGACATTCACCCAGATTCTCGAGACTTTGTTCGTAAATATCTTGAACAGTACCCAGAAAGACCAATGGTCAAGTTACAACAAGGCCAAATTGTTAAAACTGAGTGGAGTGGAAAATGGTGGATAGCGCGAGTGGTAGAAGTAGATGGATCAATGGTGAAGATGCATTTTGATGCAGACAATCGCTCTGAATGGATTTATAGAGGTTCAACTCGATTGGGTCCTCTGTTTGCTGAGCTAGCAAAGGGAGCCTATAGGAAAGAACAAGGCACTTTTCGACATCGGGGTCTTGGCATAGCATCtctgaaaaagagaaacatgcCATACGTCGAGTACACTCGAAACACTGATACTGAGGATACAAAAACTTCAGAGTCTGCTCCAGTACGTTCTGTGGCCAGGAAAAGTACGACAAGACTCCCAGATTACTATCAGGAAAACATTCCGAATCAAATTGCCCTCGGCCAGGAAAGGCTATCACAAGTAGGTAAAGTGGAAGAAGTGATTATTACCACAAAAGCCAAACCTAGAAGTTTTACTCGCCATCAATGCAGTCCTAGATGCTTGacagaaaatacttttgatttGAAGAATTTTCGAGGTGTCAACCCTTTGTGGATACCAATCATATGTGGCTGGCGTCGAGAGATAATTCATTTTCGTACCAAAAGAGTTATTGTTTATCGAACACCATGTGGTCGTCGTCTGCGGCGAATGGATGAACTTCATAGGTACCTTAATGTCACCAGGGCACACTTGGGAGTGGATTTATTTGATTTCGACCACTGGGTTCATATTGCAGCAGAGTACACTTTAATTAACcctggatttataaaaattaaagatctGTCATATGGAATTGAAAATGTTCCAGTTCCTTGTGTTAACTCTATTGACCACACTGTACCAGATTATGTTCCTTATTCTACTGTGCGTCAACCAACGGCCGGTGTGTTCCTGAATACTGATCAAGAGTTCTTGACTGGATGTAATTGTGAGGATGATTGTAATGATAGGAGCAAATGTTCATGTTGGCAGCTCACAATTCAAGGGACAGGCTATGGGTCGAGTGGAGTAGTTGATACAACAGTTGGCTACAATTACAAAAGGCTTCCAGAGCCAGTCATCACCGGTATTTATGAGTGTAACTCTCGTTGTAAATGCAGTACTACTTGCATGAATCGTGTGGCACAACAGCCACTTCAGCTCAGGCTACAAgttttcaaaactgaaaatcgTGGATGGGGTATTCGCACGTTACATGACATTCCTCAAGGGACCTTCATTTGCATTTACGCCGGTCATTTGTTAACAGATCAAGAAGCCAACGAAGGCGGTAAAAATTATGGTGATGAATATCTTGCAGAGTTGAATTACATAGAAGCAGTGGAGAGGATGAAGGAAGGATATGAGAGCGATATTTTAGAGGATGATGAAGGGGATACAGAGGAAAAACAAGTGAATCAAGGTCACTCCAAACCAACAAAAGAATTAGAAACTGGATCAGGCAAAGAGAGTTCTGGAGAAAGTGAGGAAGAAAATAGCCAGGATACAAGAGGCATGGATTCGGACGAAGAATTTAGACCAAATTGGGTAAAAAAGAAAGTGGCATCTAATGCCGGGAGCTCTATCAACACTCGACTCAGAGAAAGAACATCTCGTCATAGTTCCAATGACAGTGAGGGTAAAGAGAAGAAGCTTAAGAACGTGATCACTAAAGTGGAAAAGCAAGTTCTACAACATTCCACCAGTGAGGATGTTATAGTTTTGAGTGACGAAGAAGACACTGATATTGTCCGCAAACCATCAAAGTTTGCTGTCACGGAGGAACCAAAGAAAGGTGATAATACGGCATCAAGTTCACCGTCTCTCTCCAAGTACAGATCTGTTAGAGAATTGTTTGGGCCAAAGGAATATTGCTACATCATGGATGCAAAGAATAGTGGTAACATAGGACGCTATCTGAATCATTCTTGCAGTCCAAATGTATTTGTCCAGAATGTGTTTGTAGACACGCATGACTTGCGTTTCCCCTGGGTTGCATTTTTTGCACTATCTTATATCAGCGCAGGTACAGAACTGACCTGGGACTACAGTTATGACATCGGCAGTGTGCCCGGCAAGGTGTTGCATTGCCATTGTGGTTCCACTGAATGTCGAGGGCGTCTGCTTTAG
- Protein Sequence
- MASKPNNKPEEIVIDSDDDYSDDDVEDNVYLPSDVMTLVEDNIQDIIESTMNKYDVNFQLNKGDKILEKRVAKLEQKTTEVDENFNDIQKSLDETMSLLYNDFAPLIKELPPITIVDDGVLPINDLTSHHTATLMKYGSHKSAKKHFSPDDGRRPLGVAMKKVTQVRQCLLGNNTSETSVSDAEGNIVQEMVVPDVVALEQVDVTHKPLPPIGPIPRPTPQPGDIVYVMKLSFYGLWSRAKIIEILPKGTKENNVSSEYISDMFKVKFESTYRKSNPVKVVQGKQMAYPTPCPMRYHVGTRVIAIFSEDERSKESFYAGVIAEPPKSMNKFRYLVFFDDGYAQYISHEKILLVCESSKQVWEDIHPDSRDFVRKYLEQYPERPMVKLQQGQIVKTEWSGKWWIARVVEVDGSMVKMHFDADNRSEWIYRGSTRLGPLFAELAKGAYRKEQGTFRHRGLGIASLKKRNMPYVEYTRNTDTEDTKTSESAPVRSVARKSTTRLPDYYQENIPNQIALGQERLSQVGKVEEVIITTKAKPRSFTRHQCSPRCLTENTFDLKNFRGVNPLWIPIICGWRREIIHFRTKRVIVYRTPCGRRLRRMDELHRYLNVTRAHLGVDLFDFDHWVHIAAEYTLINPGFIKIKDLSYGIENVPVPCVNSIDHTVPDYVPYSTVRQPTAGVFLNTDQEFLTGCNCEDDCNDRSKCSCWQLTIQGTGYGSSGVVDTTVGYNYKRLPEPVITGIYECNSRCKCSTTCMNRVAQQPLQLRLQVFKTENRGWGIRTLHDIPQGTFICIYAGHLLTDQEANEGGKNYGDEYLAELNYIEAVERMKEGYESDILEDDEGDTEEKQVNQGHSKPTKELETGSGKESSGESEEENSQDTRGMDSDEEFRPNWVKKKVASNAGSSINTRLRERTSRHSSNDSEGKEKKLKNVITKVEKQVLQHSTSEDVIVLSDEEDTDIVRKPSKFAVTEEPKKGDNTASSSPSLSKYRSVRELFGPKEYCYIMDAKNSGNIGRYLNHSCSPNVFVQNVFVDTHDLRFPWVAFFALSYISAGTELTWDYSYDIGSVPGKVLHCHCGSTECRGRLL*
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01448578; iTF_01450603; iTF_01445679; iTF_01445680; iTF_01444791; iTF_01446615;
- 90% Identity
- iTF_01448578; iTF_01450603; iTF_01445679; iTF_01445680; iTF_01444791; iTF_01446615;
- 80% Identity
- -