Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.0019 44 6.6 0.0 17 47 104 135 95 140 0.81

2 8 0.00087 20 7.7 0.0 21 44 137 160 133 163 0.92

3 8 0.061 1.4e+03 1.8 0.0 21 43 165 187 162 196 0.76

4 8 0.012 2.8e+02 4.0 0.0 21 44 193 216 188 220 0.90

5 8 0.00018 4.3 9.8 0.3 21 45 221 245 217 248 0.90

6 8 0.0045 1e+02 5.4 0.1 21 44 249 272 247 281 0.85

7 8 0.089 2.1e+03 1.2 0.0 22 45 278 301 274 308 0.83

8 8 0.0044 1e+02 5.4 0.1 18 43 302 327 297 336 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.0019	44	6.6	0.0	17	47	104	135	95	140	0.81
2	8	0.00087	20	7.7	0.0	21	44	137	160	133	163	0.92
3	8	0.061	1.4e+03	1.8	0.0	21	43	165	187	162	196	0.76
4	8	0.012	2.8e+02	4.0	0.0	21	44	193	216	188	220	0.90
5	8	0.00018	4.3	9.8	0.3	21	45	221	245	217	248	0.90
6	8	0.0045	1e+02	5.4	0.1	21	44	249	272	247	281	0.85
7	8	0.089	2.1e+03	1.2	0.0	22	45	278	301	274	308	0.83
8	8	0.0044	1e+02	5.4	0.1	18	43	302	327	297	336	0.82

Coding Sequence: ATGTTCCCCTGCAGCTTTTGCGACAATGTCTACACCAGACCAGAGTATCTCGGGAGGCACAACTGCAGGAGGAGTAAAATGTCAAAGGCCAAAAGTCGACGCAAGAGGCCTGTTGAATTTATCTTCAACGAAAGTGAGCCTAGGAACAGCGTCATCAGACCGGACAGGTTCTCTTGTGGCGTGTGTGGCAAGATGTTTGTTCGGCGCTACCATCTCACGGCGCACGAGAAGTACCATTCTAATGTCAAACCGTTTGAGTGTACGATGTGTGACTCGAAGTTCCACCGGAAAACAGACCTGACTGTGCACTCGCGCATTCACAGCGGAGAGAAGCCATTTGAGTGTACAATATGTGGGGCGCGCTTTAATCAGAACTCTATACTAACCACGCACGTACGCATCCACACTGGCGAGAAACCGTTTGGCTGCACCGTGTGTGGGGAGAAGTTCCGCAAGAGCTCGTACTTGAAGAGACACTTCATGAACCACACGGGGGAGAGACCCCACGTGTGTTCTGTATGTGGGGCCAAGTTCAGACTCAAATCTGTGTTTACCGCTCACTTTAGGATACACACGGGGGAAAAACCGTTTGCCTGTACATTTTGCGACTCGCGGTTCAAACAGAACTCTGACCTGAAGGCCCACATCAGGACGCATACGGGAGAGAAACCATATGCTTGTACCATCTGTCCCGCGCGTTTCAGCCAGAGCTCAGCACTCAAGTCACATGTACGCATCCATACAGGCGAACGTCCGTACAGCTGCAATGTTTGCTCTCTGAAGTTCAGAGCAAAGTCAGATCTGAAACGACATTCGTTCACTCATGTGGCGGACAAACCATTCAACTGCGGAGATTGCGGCGCTAAATTCAACCAGCTGGCGCATCTTAGGAACCATACACGCCGACACACAGGTGAGAAGCCATTTTCTTGCCCACTTTGTGGTAAAAAGTTTGGTCGGTCGTCAACTCTTGCCAAGCACAAAGCAAGTCACAAGGAGATACGATACAACTGTTTGGAGTGCCCCGAGAAGTTCAAGACGTCGGTTGATCTTATAAAACATATCAGGAGCGCTCACAAGTGA
Protein Sequence: MFPCSFCDNVYTRPEYLGRHNCRRSKMSKAKSRRKRPVEFIFNESEPRNSVIRPDRFSCGVCGKMFVRRYHLTAHEKYHSNVKPFECTMCDSKFHRKTDLTVHSRIHSGEKPFECTICGARFNQNSILTTHVRIHTGEKPFGCTVCGEKFRKSSYLKRHFMNHTGERPHVCSVCGAKFRLKSVFTAHFRIHTGEKPFACTFCDSRFKQNSDLKAHIRTHTGEKPYACTICPARFSQSSALKSHVRIHTGERPYSCNVCSLKFRAKSDLKRHSFTHVADKPFNCGDCGAKFNQLAHLRNHTRRHTGEKPFSCPLCGKKFGRSSTLAKHKASHKEIRYNCLECPEKFKTSVDLIKHIRSAHK*

Sequence clustering based on sequence similarity using MMseqs2