Basic Information

Gene Symbol
-
Assembly
GCA_901482245.1
Location
CABEEJ010001163.1:153550-176621[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.13 31 7.5 2.2 1 23 227 249 227 249 0.93
2 13 0.0002 0.047 16.4 1.4 1 23 254 278 254 278 0.94
3 13 0.00021 0.049 16.4 0.8 2 23 302 324 301 324 0.95
4 13 0.001 0.25 14.2 1.3 1 23 330 353 330 353 0.94
5 13 0.00057 0.14 15.0 0.6 1 23 366 389 366 389 0.90
6 13 1.4e-06 0.00032 23.2 2.6 1 23 395 417 395 417 0.98
7 13 3.7e-05 0.0088 18.7 0.4 1 23 423 445 423 445 0.93
8 13 0.00017 0.04 16.6 2.3 1 23 451 473 451 473 0.97
9 13 9.3e-08 2.2e-05 26.9 0.9 1 23 479 501 479 501 0.99
10 13 2.3e-05 0.0055 19.3 5.8 1 23 507 529 507 529 0.97
11 13 0.89 2.1e+02 4.9 6.3 2 23 536 557 535 557 0.96
12 13 3.5e-05 0.0084 18.8 1.9 1 23 563 585 563 585 0.98
13 13 2.8e-06 0.00066 22.3 5.2 1 23 591 613 591 613 0.98

Sequence Information

Coding Sequence
atgGTAGAGTTGAACCGGAGATTGGAGAAGGAACGTCAGAGGTCGGAACACACCGGTATCAGTTTACTGGTCACCACGGAGACCCCGGTGAATGCCGATGGAGAACAGGATGGCGAGGAAGAGACTACAGAGAAGCGAATTGTAATCCAGATCCTGGAGGATGGCTCCTTGTACGCCCCAGATCACAAGATGACCCTTCAGATGGAGGGTCTGGAGAAACCACGGCGAAAGCGCGGCCGCCCGCCCAAGCGCCCGCCTGATCCTGAGGAAGACAGGCCCAAAGAACTGGAGGAACCCTTGGAGAACCAGCCAGAGGAGGAAATGGAAGAGGACGCAGATGGGCGCAAGCGACGCAGGATAAAAGTACCGCAGAGATTCAAGGAGGCGGTCCAAGGTAAGGAGTTGGACCGTATCTTCAAGGAGGAAGGTTTGATAAACGAGGACGAAGAAGAGGAAGGGGTGGAGGAAGAGGAAGTGCAGGAGAAGACTCCTCCACTTGAAGTTATTGCTCAGGAAGGTTGGCAACAAATCACTCTGTACGTCTCGTCTCGTGCGACAGCACAAAAGGTGATTGGTCACTTGGAGACCCAGGAGGGGCAGGACCTAGGGGAGCTGGTGATCGTAAACCGTGGCCGCAAGAGGGGCCGGCCGCGGGGCGGGAAGCGCCGGAAAGTTCGCTTTGAATGCGAGATCTGTGGACGGGGCTTCCTCCACAAGGGTCGCTACAAGATTCACAAGACCTACCACAAAGGAGTCAAGTTTGAGTGCAGCAGCTGCAACAAGAGGTTTGTCAACCGAGAGCTATTTGAGTCTCACCAGAAAACTACGGGGCATGTCGGCGAGGGCATAATCGAGGGGCTGGCAGACGGAGGGGATGGGGGGGAGATGCCAGGCTGCCGGGTGAAGTGCTGGCAATGCGATAAAACTTTCCAGACCAAGCAGAGCTTTGAgGTTCACCAGAAAGCCATTCACGAGGGAGCTAAGCCCTTTGTTTGTGAGGTTTGTGACAGGACCTTTGCCTACCAGAACAGCCTTAAGTGCCACATGCTGGCATCGCATTGtgagGACACGAAAGGTCTGGACAAAGACAAGGGCTACCCTTGTGACATGTGTGACAAAAAGTTTAACCACCCCAGCTCGGTGATTTACCACAAGGAAGCGGAGCACAACAACGGCCGTGTGTTTGTCTGCAACAAGTGCGGGAAGGGCTTCAGACACCGCCAGTTGCTGCAGAGGCACCAGCTGGTACACTCGGAGGACCGTCCGTATGTGTGTAAGTCGTGTGGTGCGAGCTTCAAGACCAAGGCCAACTTGCTGAACCACCAGCCGACGCACACCGGAGAGAAGAAGTATTTCTGTGAGCTCTGTGGTCAGCAGTTCGCGCATAAGACTAGTCTCACCCTCCATTATCGCTGGCACACAGGCCAGAAACCGTACAAGTGTCAGGTGTGTAGCAAGAGCTTCTCGCAGAATGGAAATCTACAGGAGCACTTGCGGATACACACGGGGGAGAAGCCCTTCTGTTGCGACTACTGCGGCCGCAAATTCACCACCTCCTCCCAGTTCAAGCTGCACGTCAAGCGGCACACGGGGGAGCGACCGTGGAAATGTGACTTCTGCGGGAAGTCGTTCCTGCACAAGGACACGTGGAAGTGCCACACGCGGCGTCACAAAGGCGAGCGTCCCTTCCAGTGCCACTACTGCGCCCGAGGCTTCACGGAGCAGTGGGCCCTCAAGAAGCACCTTCGACTTCACACAGGGGAGAAGCCTTACACTTGTAACACTTGCGGGAAATGTTTTGCCGACTGCTCGAACCTCGCCAAACATAAAAAGGTCCACAAGGGCAGCTGTGAGAACGAAAGCACCGCTCCAGGGGACTCTCTCGTGGACCGCACCACCGTCTGGAACATCATCCAATCCCACTTGGCCAAGGATGTTTCCGAGCAGGACGGGGCAGACTCCCAGGGAGAGGACGCAGGTCAACAGATCATCTACGTCACATACCAAGACCCTGATGACCCCGAGGGCAAAACGTTGCATATTGTCGACTCCCAACAGAACCCACAGCACTCCGAGCTGGAACAGTCCCAGGAACAGCGTCAAGTGGCGCTGGGGGAGACTGAGGAAGTCGGAGAACTGGAGGAGTCGAAGGGCTCTCTGGGGTCTCTGCCCCACTCTCTTCAGGTGATGGACGAGGAGGGTAACCCCATCCACTTCACCATGCAGGACGGTCGAGAGCTGCAGATCACGACGACGGACGGTCAGTCGTTGCATGTGACCACTCTGGACGGTCAGACCATCCCCTTGCAGCTCACCACCCCGGATGGACAACCCCTTACCGCGGGCGGGCCGGAGGTCAGGGTTCATCCCTCTGACGACAACCTCATGATGGGACAGCCCTCGGATGACCTCATCGTCCAGGAGCCGCACACCCACCCAAACGGGATGCTGAAGAGCGTTAAGggaAGTGAAAGATTGTCAGGTGAACCTCTGGCTGAGGGGGAGCAAGCCATCGAGTTCACGACGCCCGACGGTCAGAAAGTGAGGCTTGTGACTTCTTACGGGGTGGACCCCATCACAGAGTACCTCAGCACTAACACGTAG
Protein Sequence
MVELNRRLEKERQRSEHTGISLLVTTETPVNADGEQDGEEETTEKRIVIQILEDGSLYAPDHKMTLQMEGLEKPRRKRGRPPKRPPDPEEDRPKELEEPLENQPEEEMEEDADGRKRRRIKVPQRFKEAVQGKELDRIFKEEGLINEDEEEEGVEEEEVQEKTPPLEVIAQEGWQQITLYVSSRATAQKVIGHLETQEGQDLGELVIVNRGRKRGRPRGGKRRKVRFECEICGRGFLHKGRYKIHKTYHKGVKFECSSCNKRFVNRELFESHQKTTGHVGEGIIEGLADGGDGGEMPGCRVKCWQCDKTFQTKQSFEVHQKAIHEGAKPFVCEVCDRTFAYQNSLKCHMLASHCEDTKGLDKDKGYPCDMCDKKFNHPSSVIYHKEAEHNNGRVFVCNKCGKGFRHRQLLQRHQLVHSEDRPYVCKSCGASFKTKANLLNHQPTHTGEKKYFCELCGQQFAHKTSLTLHYRWHTGQKPYKCQVCSKSFSQNGNLQEHLRIHTGEKPFCCDYCGRKFTTSSQFKLHVKRHTGERPWKCDFCGKSFLHKDTWKCHTRRHKGERPFQCHYCARGFTEQWALKKHLRLHTGEKPYTCNTCGKCFADCSNLAKHKKVHKGSCENESTAPGDSLVDRTTVWNIIQSHLAKDVSEQDGADSQGEDAGQQIIYVTYQDPDDPEGKTLHIVDSQQNPQHSELEQSQEQRQVALGETEEVGELEESKGSLGSLPHSLQVMDEEGNPIHFTMQDGRELQITTTDGQSLHVTTLDGQTIPLQLTTPDGQPLTAGGPEVRVHPSDDNLMMGQPSDDLIVQEPHTHPNGMLKSVKGSERLSGEPLAEGEQAIEFTTPDGQKVRLVTSYGVDPITEYLSTNT*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_01450895;
80% Identity
-