Tdou007577.1
Basic Information
- Insect
- Timema douglasi
- Gene Symbol
- E2F8
- Assembly
- GCA_901482245.1
- Location
- CABEEJ010000416.1:97934-113867[-]
Transcription Factor Domain
- TF Family
- E2F
- Domain
- E2F_TDP domain
- PFAM
- PF02319
- TF Group
- Helix-turn-helix
- Description
- This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 8.4e-17 2.6e-12 48.6 0.1 11 65 12 70 4 70 0.91 2 2 6.5e-17 2e-12 48.9 0.0 3 64 209 304 207 305 0.92
Sequence Information
- Coding Sequence
- ATGGTGCAAGTATCTGTGCTGTATTATCATCTTAGGTTTCTGGAGTTTTACCCTTTGAATGTGGATCCAAGTACTCGAGTCGTCATCTCCATTGATAGGTTGGCTGACCTTCTCTGCACCGAGAGGAGACGGGTCTACGACATCATCAACATTCTTGAAAGTCTGCAGATGACTGTTAAACTCTGTAAGAACCGCTATGAATGGTATGGCTGCAAACAGCTTCATGTCACCTTGGCACACCTGAAGGGGTTTGCTGTCAAGTTGGGCCTTCACAAACAGGTCAGGTTTCCAGAAGTGGAAGTTGAGGATTTTATGGAAACTTCTTTGAAGATCGGCAAGGTCTTTGAGGCAGTTGCACAACCTCTTTCTGTTAAGAGCTCAACGCCACCATATCCTGACACCCTCACTGAGACATCAGCGAGACCTTTATCAGTCATGAGTATTGGTCAACCGCCCATGGATGTTGTCACAGTGACTGTAAGCTCAGAAGACTATATCAGAAGTAAATACCAGCCCATCCTGCCCAAAAAGGTTGAGTTGTTGTCCGGCAAAGATTCTGAGGATGTGGGGAGTACAGAGGATTTATGGGGGGACCTTGATATGGAACGAGATATCAGAGACTGCAACTCTCTTGGGGTTCTGTGTCAGAAGTTTGTGATGCTCTTCCTACTGACCAACAAGACGCAGTTGCTGACCCTGGAGCTTGCCTCCAGAATCCTAGTGGGTGGGGTGATGGACCGCCTAGTGAATGATATTACAGGAAGAGCTTATACCCCAGACTCACCACCATTTCAAGGTTCTGTCAAAACCAAGGTTCGACGCTTGTATGACATCGCAAATGTTCTGACTTCACTGCGCCTCATCTGCAAGGTACAGGCGTCCAACCTTAAGAAGCCTGCATTCAGGTACACAGGGCCCATCGTGGATGCTGCAGGGCTTCCACACTTAGCGACCCTGGTGCAAGTGACTCGACAATCTATGCTGGGCCCACACCACCCCTCGCTGATGAAGAACCATGGTGTGTTGGTGCTGTTACCTGATTGTCACACTCGCTGGATGGTGGTCCCAAGTACCACTCAGGAACCAATCAAGTGCTATCACAGGAAGAGAAAACACTTCAGTGGCCCCACAGATATTGCCTTGAAAATGCCAAGAACAAGAAGTGACAATACCCTGACTCAATGTAAGGGTCAGACGAGATCCAGGCACAAATACGCAGATCACTGCTCATTGAATAGCATTCTGAATGTTGCTGAGATGGAACtgattaaaatgaaaaaggAAGAAAGTTTACCACAGGACAGGCTTACATCCCAAGGCGCAGATCGCTATATAGCACCGTTTTACACCAAGAAACGGCCATTCTCTAGGCACCATTCTGACTCCTGTGTAACTGAGAGCACTATTCAATGTGACATTGAGGCTCCAAATGGAGAGTTGAGCAACAAAACTAGTAACTCAAATATCAATAGCTTGAGTAATAATGATGCTTACAAAATCACTCTACAGCATTCTGTGGCAAAGCTTGATGAACTGGAAATGGGTAATTTTGGTAGCCCTGATAATACAGTAAATTTCACAGATGATTCTATAAAGAATGAGGTGACTAAAATCTATTATGGCCTAAAGAGTGTTGAAAGAAACTCAAAACTCAAAAATGGGGTTGAAACTAATTATTCAGATAATGATGGTTTAGGAAATAAGACAGCACTTATCAAAGGCGAGGACTCAAAATCACTGCCATTACCAGAGAGTTTAAAATGTTCTACTATGGTGAGTAAAAGGTCCAATAACATCGACACTAGCGAAAATAATCCACCTGATTGCATCAGCCACCCATCAGGACAGGAGATGCAAATGGTCCGTAAACTCGTCAAACTAACACCTCTTGTATCTCGGCAGAAAGTGTGTTCTTCTAACAGCTACCTTATTTCAAACTCTGAACACATGCCTTCATATTCGGGTAAGATGTTGCTCCTCGATAGGAATGATTCAGAGAATTCAAAATCTGTTAGAGTAGCCAAGCGTCTTACTACAATTGACTTAAGCAATGTGGCTCGAAGTATAGAGTCTAGATCAATGAAACCAAATGATTTGACAGCGAAGAGCATGAAACTGCTTATAAAAGGGAAAACCATAGAACTTACAAAACTGGTGAAAGTTGGAAACATAATGGAACTAATCAACCCTGTGCAATGTGAATTCACTTGA
- Protein Sequence
- MVQVSVLYYHLRFLEFYPLNVDPSTRVVISIDRLADLLCTERRRVYDIINILESLQMTVKLCKNRYEWYGCKQLHVTLAHLKGFAVKLGLHKQVRFPEVEVEDFMETSLKIGKVFEAVAQPLSVKSSTPPYPDTLTETSARPLSVMSIGQPPMDVVTVTVSSEDYIRSKYQPILPKKVELLSGKDSEDVGSTEDLWGDLDMERDIRDCNSLGVLCQKFVMLFLLTNKTQLLTLELASRILVGGVMDRLVNDITGRAYTPDSPPFQGSVKTKVRRLYDIANVLTSLRLICKVQASNLKKPAFRYTGPIVDAAGLPHLATLVQVTRQSMLGPHHPSLMKNHGVLVLLPDCHTRWMVVPSTTQEPIKCYHRKRKHFSGPTDIALKMPRTRSDNTLTQCKGQTRSRHKYADHCSLNSILNVAEMELIKMKKEESLPQDRLTSQGADRYIAPFYTKKRPFSRHHSDSCVTESTIQCDIEAPNGELSNKTSNSNINSLSNNDAYKITLQHSVAKLDELEMGNFGSPDNTVNFTDDSIKNEVTKIYYGLKSVERNSKLKNGVETNYSDNDGLGNKTALIKGEDSKSLPLPESLKCSTMVSKRSNNIDTSENNPPDCISHPSGQEMQMVRKLVKLTPLVSRQKVCSSNSYLISNSEHMPSYSGKMLLLDRNDSENSKSVRVAKRLTTIDLSNVARSIESRSMKPNDLTAKSMKLLIKGKTIELTKLVKVGNIMELINPVQCEFT*
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01450261;
- 90% Identity
- iTF_01450261;
- 80% Identity
- -