Tobe016591.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Thera obeliscata
Gene Symbol
ibtk
Assembly
GCA_947578465.1
Location
OX387913.1:8831464-8856121[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 3.1e-15 1.1e-12 48.6 0.0 7 79 548 619 542 625 0.88
2 4 0.89 3e+02 2.0 0.1 86 107 689 710 679 712 0.80
3 4 2.4e-11 8.3e-09 36.0 0.0 9 107 737 840 731 843 0.81
4 4 2.2 7.3e+02 0.8 0.2 79 107 844 872 840 875 0.87

Sequence Information

Coding Sequence
ATGAGTAAGCATAAAGTTGAAGTAGACTGCACCAATCGGTGCCGGTCTCGGAGCCATGGCCAGCTACTTACAAGTGCTATCACGAAGAGGTCTATCACAGATAAAGATTTGGCCAGTTATATCAAAGGGACCTGTGCTAACTTCAACAAGGCATTTGACTTTGAGGGTCGCACTGCCTTGCATATGGCAGCGTCCCGAGGGAGAACTGATCTGATGAACTGGCTCGTTCGTCATTCTTCGGAGGCTTTCGCGAACGCGCGTGATCGTGAGTCAGGATACACGCCACTGCATAGAAGCATCTTCTATGGGCAGATCAATACCGCTGTTGCTCTCATGAAAATGGGAGTAAAAACGGACATAGTCGACAAAGACGACTACAAAGCTCTAGAACACGCTTTGCTAGATCGCGCATACATGTACAAACATGACCCCCTACAACCTTGCGACTCATACGTGTGGGGGACCAATTGTAACTACACACTGGGCACCGGGTCCAATCAGCCCCGAGCAGTGCCGGAGGCCTTGGCTACGTTTAATAAGGCTGATACAAGCGTGAAACAGGTGTGCCTAGGCAAGTTCCACAGTGTCTGGTTATGCGACGGCTCTGTCTGGTGCTGCGGCCAGCTGGCTCGCGCGGGGGCGCCTCACAGCACGGCGCTGCGGCCTGCTCTGTTGCGGCTGGCTGAGCCGTGCCTGTGTGTGGCGACCACACTCAACTCTACTGTGCTGCTGATGGACAGCGGAACGGTGATCCAATACTCTCTGAACAGCACTGACAACATCAGTCAATCAAGTACAAAAACGCCGTCGTCCATCAAGTTGCCGTCAGTCAAGCCTTTGATGAAACTGTCAAACCCTCTCGGCGTGCGTGCGGGGAAGTCCCATGCTGTAATGTGGAACAAAAACGCGGTTTACACTTGGGGCACTAACGTGGGGCAGTTGGGGCACTCGCCAGAGGACAAGATTGTGAATATGCCTAAAAGGGTAGCAATATCGATGAACACGAAAGAAGACGTCGGCATAGAGTTAGTGGAGGCCGGTGATGCGGCCACTGTTATAACGACATCGCGCGGAGATGTGTATCTGCTGCATAAGTATATTTGCAAGAAAATCGCTATCAAGCAGATCAATTTACGTCAAGTGTGCGTGGAAGGCAAGGTGAGCGATCAACGCGCCTACTCGCGAGTAACTGTTCTATTGCTCACCAAAGTGGGACAACTACATATTTGGCAAGACACATCCAACCAGCTTACAAGATGCGTATTCGGTTTAGTCCATCAAACTCTAGTAACACACATGGCATTAACACATGACGCCCTATACCTCACCACTAAGCATGGAGAGGCGTACATCGGCACAATATCTCGAAAGGCATCCTCTACTCCCCAGCCGACCAAGAAGGAGAGAGAAAAGGACGGGAGATCAGCGCTAGTCAAGTTCTTAGACAAGGATGACTGTACTTCTGTCAAGATCGTGAAGATTCCAAATGTGCATCGCGCTGTTTCTATAGCAGTGGATGCGGAGGGACTTAATTTTGCTGTTTTGCAGACGAAACCCACTTGCGGTCTGAGATGTCTCCCCGAGTTGTCCCCCTCATGCTTCTCGAAGCACATGGAAGCACTGCGGGAGACTGCGACCGAAGATGACATTTTACACGACGTCATATTTCAGATCGGCACAAAGCGATTCCCGGCACACATCTTCATAGTCGCCTCGAGCAGTGATCACCTTTACAAACTGTACCAGGATACCATAGCTACCCAGGGAGATAAACCCACTGTCAATCTCTCGAACGTACATCCAGATGTTTTTGAGAGAATCCTGAAATTCATGTACACTGGAAGTTGTGATGTAGCGGAATTAGGGCCGTGCAGCCTCAAGATAAGGAGGGAAGATCTAGTGGGCAAGAAAGATAAAGACGGAGATATCGATGAAGAGATCGAAACCCCAGCTGAAATCTCCGCGTTCGAAGTCTACAAAGAGAGGAAGAAAGGTTCTAAGAACAAACGCTCCACCACAGAGACCCCTCGTCCAATCCATGTGTACTGCGACCCCGTGAAACTGGTGCAAGCGGCCGCCAAGAGGCTACAAGTCATGGCCTTGCACAAACTCTGCGATAAATTCTATTACAAAGATGGCAAGGTCTGCCTAAAAGACAGTGCAGACTACAAACGCACACCAATGCACTGGGCCCGCGAATCGTTCCATGACCTAGTGGACACCAACGTGTGCACTAAAGACGGTGCACTAATACCGGCGCACAAGTGCGTGCTGGCTGCTAGACTGGAGTACTTTAATGGAATGTTTATGCATTCTTGGACTGAGAGTAAGCTGTTATCTACCGTCACTCTACCAATAAACTACGGCATTCTTCTGCCTGTTATAAACTTTTTGTACACAGACTCATGCCCTGAAATCGAAGATTGCAATGAAAGCATCGATTTTATATGCAATATGCTTATAGTCGCCGACCAGCTGTTTATATCAAGGCTTAGAGAAATGTGTGAAGGGGCGTTAGCTAATATGGTAACTCTGAAAAACTGCACCGAACTGTGCCAATTTGCGCACACTTACAACGCAACACAGCTTAAACAATGCTGCATGGAGTTCATATCTCTAAATCTATCGTCAATTCTTGAAAACAGATCGCTTGAAAACTTAGAGCAAGCCTTACTCGATGACATAACCAGCTACTACTGTAAATTCAATCCGATCATGTCTTCTCGAGTTATCACTCCCTTTTACAACGCGCCAAACGATGAAACTATAGAGGAATTCACTGCCAACCATCCTGTCGATCTAGACTTAATCGACGAAGATGTCAAAAGAGATGATAGCGTTGTAGAAATATCTAAAAAGAAAACTAAGTCTAAAAAAGTTGAGTACACGGAGAACGAAAAGGCAAGGATGAGGTATGAATCTGTCAGCTCTGTGACGTCACTAGATCTATCCAACGAAGTCTCAGGGGATATCACTCTGTCGCTAAGCAAAATAAAGGATGAGAAAGTTGATAAAACTAAGAAGTGGACCGAAGTACCATCCTCTCAGCAAAAGCAACAAAAAGTTGTCCAAGCGAGATTGAAAGCTATCAGCACTGCTAAAGATATCTTGAACGAAACGCCAGCAGAATCCTTTACTAAACTCACTAAGTCTTCCTCCATTAGCATACCAGAAGCAAACATGACTACTTCTCAAGATTCGCCAGTAGCAGACTTAGCAAAAAGCCCTGTTTTTATCAGTCACGTGGGACCAAAACTGTCTCAAAAGCAGCGTAAAAAGCTAGCTTTGGAAGGCAATGAGCAATCTCCTCAGAGCATGAACGATTTCTTCAGTAGAATGAGTGTCAGCCCTCCTCCTGAGAAAAAGAATCCATGGAAGGTGGTCGAAGCGCCGATCGCCAGTAGCAGTCCTAGATGCAAGCCAGTTCAGTTCAACCAGATACTGACAGATCAGAGGAAACAGAAGGAAGACTTTTCGAGAATTATGACCAAGCCTTTAGCTTTGACACAGTTGGAAGACAAAGCTATAGAACAGCTTGAAAAATTCTACAATGCACATGAATCAGATGAAGAATACATAACCGTGCGCCGAATCGAGCTTCAAGTGTCATCACCGCAGTGGGTCCACACTGCCCCTAAATAA
Protein Sequence
MSKHKVEVDCTNRCRSRSHGQLLTSAITKRSITDKDLASYIKGTCANFNKAFDFEGRTALHMAASRGRTDLMNWLVRHSSEAFANARDRESGYTPLHRSIFYGQINTAVALMKMGVKTDIVDKDDYKALEHALLDRAYMYKHDPLQPCDSYVWGTNCNYTLGTGSNQPRAVPEALATFNKADTSVKQVCLGKFHSVWLCDGSVWCCGQLARAGAPHSTALRPALLRLAEPCLCVATTLNSTVLLMDSGTVIQYSLNSTDNISQSSTKTPSSIKLPSVKPLMKLSNPLGVRAGKSHAVMWNKNAVYTWGTNVGQLGHSPEDKIVNMPKRVAISMNTKEDVGIELVEAGDAATVITTSRGDVYLLHKYICKKIAIKQINLRQVCVEGKVSDQRAYSRVTVLLLTKVGQLHIWQDTSNQLTRCVFGLVHQTLVTHMALTHDALYLTTKHGEAYIGTISRKASSTPQPTKKEREKDGRSALVKFLDKDDCTSVKIVKIPNVHRAVSIAVDAEGLNFAVLQTKPTCGLRCLPELSPSCFSKHMEALRETATEDDILHDVIFQIGTKRFPAHIFIVASSSDHLYKLYQDTIATQGDKPTVNLSNVHPDVFERILKFMYTGSCDVAELGPCSLKIRREDLVGKKDKDGDIDEEIETPAEISAFEVYKERKKGSKNKRSTTETPRPIHVYCDPVKLVQAAAKRLQVMALHKLCDKFYYKDGKVCLKDSADYKRTPMHWARESFHDLVDTNVCTKDGALIPAHKCVLAARLEYFNGMFMHSWTESKLLSTVTLPINYGILLPVINFLYTDSCPEIEDCNESIDFICNMLIVADQLFISRLREMCEGALANMVTLKNCTELCQFAHTYNATQLKQCCMEFISLNLSSILENRSLENLEQALLDDITSYYCKFNPIMSSRVITPFYNAPNDETIEEFTANHPVDLDLIDEDVKRDDSVVEISKKKTKSKKVEYTENEKARMRYESVSSVTSLDLSNEVSGDITLSLSKIKDEKVDKTKKWTEVPSSQQKQQKVVQARLKAISTAKDILNETPAESFTKLTKSSSISIPEANMTTSQDSPVADLAKSPVFISHVGPKLSQKQRKKLALEGNEQSPQSMNDFFSRMSVSPPPEKKNPWKVVEAPIASSSPRCKPVQFNQILTDQRKQKEDFSRIMTKPLALTQLEDKAIEQLEKFYNAHESDEEYITVRRIELQVSSPQWVHTAPK