Basic Information

Insect: Tethea ocularis
Gene Symbol: gsb-n
Assembly: GCA_963555595.1
Location: OY741970.1:5442302-5456575[+]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 9.7e-71 1.5e-67 225.7 1.0 1 125 13 134 13 134 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	9.7e-71	1.5e-67	225.7	1.0	1	125	13	134	13	134	0.99

Sequence Information

Coding Sequence: ATGGAACGTCACCAAAATGGTATGGATGTGTGGGTAGGGCAAGGGCGAGTCAACCAGTTGGGCGGTCTGTTCATCAACGGGAGGCCACTCCCGAACCATATCAGGCTGAAAATCGTGGAGATGGCTGCGGCTGGCGTGCGACCCTGCGTCATCTCACGTCAGCTCCGTGTCTCGCATGGATGCGTCTCTAAGATTCTCAATAGATACCAGGAAACTGGATCGATTAGACCGGGCGTGATAGGCGGTTCGAAGCCAAGAGTCGCCACGCCGGAAGTAGAAGCAAGAATTGAAGAACTTAAACGACAGAATCCCGGAATATTCTCATGGGAAATACGGGAGAAATTAATAAAGGAAGGCGTGTCGGACCCACCCAGCATCTCGTCGATATCTCGCCTGCTGCGGGGCGGCGCGCGCGACCCTGATGGCAAGAAGGACTATAGTATAGATGGCATTCTAGGAGGTCGTGGATCAGATTCATCAGACATCGAGTCAGAGCCAGGGTTAACATTGAAGCGAAAACAGCGTCGTTCTCGGACTACCTTCACTGGGGAGCAACTGGATGCCTTAGAGCGAGCCTTCCATCGCACCCAGTACCCCGATGTGTACACCAGGGAAGAGTTAGCTCTGCAGACAGGACTCACAGAGGCAAGAATACAAGTGTGGTTCTCTAATCGAAGAGCTCGTTTGCGCAAACACACTGGTTCAAACCCAACACCAAGTCTCGCTGGTTACTCTTCGATACCGATGCCTCAAATCCCCTGTCCTTATCCTGCAGGAGAAATACCCTCTCTATCTCAACACCATCCTCAACATCCAGATGCTTGGCACCATCAAAAGTACGCCAACTATAACCAACTTATGGCACAATCCCAACATTTGAACCAAGCATTTCAAAATGCTGCCTTTCCTAGTACATCTGGATCAACTTTTGGACATTTAGTCGCCGGAAGCAATGGTCCCCCCCATAGCCAAATACTAGAAGCTGGTGTACCAAGAAATGACTATGCTAGATATCCAAGCAATGATATCTATAATAAACCTATTAACTATTTACCCAAAGAAACCGAAGGGGACGATAAAGTAACCAGTGATGAAGTAATTGAGCCTAGAGAAGATACTTTTGTGAAGCCATCTGCAGACGATTATAATAAAGCGTTACCAAATAATGATTACCCAAAAGTTCCTGCTGACTATTCTAAGGTATCGGTAGATCCATCTGCATCTTCTAATTGGAGCCCGTCTCACAATTCATTAAACATGAGTCTGGCAGGTATTTCCagtgaatataaatatatgaatGATCCATACTCATTTCCTAACGTAGCCGATCCTCTAAATCAACACAGTTATCCAAATCCACCCAATGCAGCCAACAAATACTGGATTTGA
Protein Sequence: MERHQNGMDVWVGQGRVNQLGGLFINGRPLPNHIRLKIVEMAAAGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRVATPEVEARIEELKRQNPGIFSWEIREKLIKEGVSDPPSISSISRLLRGGARDPDGKKDYSIDGILGGRGSDSSDIESEPGLTLKRKQRRSRTTFTGEQLDALERAFHRTQYPDVYTREELALQTGLTEARIQVWFSNRRARLRKHTGSNPTPSLAGYSSIPMPQIPCPYPAGEIPSLSQHHPQHPDAWHHQKYANYNQLMAQSQHLNQAFQNAAFPSTSGSTFGHLVAGSNGPPHSQILEAGVPRNDYARYPSNDIYNKPINYLPKETEGDDKVTSDEVIEPREDTFVKPSADDYNKALPNNDYPKVPADYSKVSVDPSASSNWSPSHNSLNMSLAGISSEYKYMNDPYSFPNVADPLNQHSYPNPPNAANKYWI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00942792;
90% Identity: iTF_01415673; iTF_00640289; iTF_00072578; iTF_00011792; iTF_00072784; iTF_00011955; iTF_00012787; iTF_00146392; iTF_01302139; iTF_00012988; iTF_00640125; iTF_00146240; iTF_01302304; iTF_00450083; iTF_00907850; iTF_00907726; iTF_00449967; iTF_01025830; iTF_00300001; iTF_01028258; iTF_01030978; iTF_01030180; iTF_01119301; iTF_01029063; iTF_01026152; iTF_00300169; iTF_00783433; iTF_00784361; iTF_01031113; iTF_01118282; iTF_01192682; iTF_00771723; iTF_00888237; iTF_00111630; iTF_00771886; iTF_01027150; iTF_01028110; iTF_00850447; iTF_01230543; iTF_00783280; iTF_00851570; iTF_00784244; iTF_00850708; iTF_00952693; iTF_01029237; iTF_01118101; iTF_01027286; iTF_00951639; iTF_01030007; iTF_00951800; iTF_01192472; iTF_00111449; iTF_01230361; iTF_00851770; iTF_01117019; iTF_00952541; iTF_01117181; iTF_00888063; iTF_01119135; iTF_00468039; iTF_00468141; iTF_00723821; iTF_00723924; iTF_00942792; iTF_00942658; iTF_01264584; iTF_01264245; iTF_00967898; iTF_00967996; iTF_01363080; iTF_00120481; iTF_00176961; iTF_00237313; iTF_00273569; iTF_00425345; iTF_01064481; iTF_01439905; iTF_01440833; iTF_00043458; iTF_00172578; iTF_00186146; iTF_00445954; iTF_00745474; iTF_00809090; iTF_00363875; iTF_01338723; iTF_01339811; iTF_01377443; iTF_00147428; iTF_01338340; iTF_01340068; iTF_01362404; iTF_00375173; iTF_00383621; iTF_00447109; iTF_00000166; iTF_00147142; iTF_00425222; iTF_01084102; iTF_00042599; iTF_00667431; iTF_01093063; iTF_01527143; iTF_00001032; iTF_00043336; iTF_00327048; iTF_00907016; iTF_01094888; iTF_01377320; iTF_00185161; iTF_00831017; iTF_01425033; iTF_00017194; iTF_00785162; iTF_01063722; iTF_00042476; iTF_00071244; iTF_00905964; iTF_01221516; iTF_00000301; iTF_00622797; iTF_01062765; iTF_00018030; iTF_00071406; iTF_00120334; iTF_00375022; iTF_01061838; iTF_01533902; iTF_00038735; iTF_00041743; iTF_00374063; iTF_00711663; iTF_00036656; iTF_00040784; iTF_00172880; iTF_00383472; iTF_00810032; iTF_00928656; iTF_01063600; iTF_01531984; iTF_00038545; iTF_00449073; iTF_01487569; iTF_01533777; iTF_01534641; iTF_00446962; iTF_00711826; iTF_00809906; iTF_00924626; iTF_01526866; iTF_00177075; iTF_00445139; iTF_00726131; iTF_01246675; iTF_01259923; iTF_00273460; iTF_00301140; iTF_00446100; iTF_01064628; iTF_01246868; iTF_01362324; iTF_01487668; iTF_00274293; iTF_01525781; iTF_00906902; iTF_01092918; iTF_00018135; iTF_00037623; iTF_00037783; iTF_00326935; iTF_01094007; iTF_00001144; iTF_00039640; iTF_00726328; iTF_00924440; iTF_00928504; iTF_01441016; iTF_00036473; iTF_00808953; iTF_00906105; iTF_00041626; iTF_00274394; iTF_00301018; iTF_00685274; iTF_01093882; iTF_01439738; iTF_00017307; iTF_00301947; iTF_00363995; iTF_00745659; iTF_00785051; iTF_01084987; iTF_01094747; iTF_00039772; iTF_00302076; iTF_01424892; iTF_00444957; iTF_00667197; iTF_00185278; iTF_00373758; iTF_00040639; iTF_00185983; iTF_00622655; iTF_00685407; iTF_00831167; iTF_01221343; iTF_00237536; iTF_00448864; iTF_01061728; iTF_01084224; iTF_01362944; iTF_01525984; iTF_01531808; iTF_00123202; iTF_00123340; iTF_00122358; iTF_00124088; iTF_00124220; iTF_00121247; iTF_00121407; iTF_00122207; iTF_01173127; iTF_01173243; iTF_01538714; iTF_01538583; iTF_01285503; iTF_01285391; iTF_01090729; iTF_01090534; iTF_00049867; iTF_01260071; iTF_01342187; iTF_01085168; iTF_01342066; iTF_00049747; iTF_00408239; iTF_00408423; iTF_00364892; iTF_00751876; iTF_00752039; iTF_01071592; iTF_01125295; iTF_00960784; iTF_01125434; iTF_00364767; iTF_00960895; iTF_01071488; iTF_00761647; iTF_00761478; iTF_01073455; iTF_01073581; iTF_01076239; iTF_01076459; iTF_00758128; iTF_00757988; iTF_00720049; iTF_00720261; iTF_01180178; iTF_01180275; iTF_01179355; iTF_01179455; iTF_00323475; iTF_00323335; iTF_00006934; iTF_00007059; iTF_00647958; iTF_00647846; iTF_00736470; iTF_00736588; iTF_01437014; iTF_01436865; iTF_01358839; iTF_01358737; iTF_00819909; iTF_00063553; iTF_00341185; iTF_00063426; iTF_00787618; iTF_00341285; iTF_00290662; iTF_01010214; iTF_00820042; iTF_00427947; iTF_00787467; iTF_00858510; iTF_00859311; iTF_01429903; iTF_00290514; iTF_00428083; iTF_01010326; iTF_01429784; iTF_00819001; iTF_00858395; iTF_00819132; iTF_00859421; iTF_01533015; iTF_01062627; iTF_01534791; iTF_01532874; iTF_01251707; iTF_01251592; iTF_01341245; iTF_01340988; iTF_01083294; iTF_01083152;
80% Identity: iTF_01415673;