Basic Information

Insect: Macrosoma leucophasiata
Gene Symbol: gsb-n
Assembly: GCA_036365455.1
Location: JAWQUS010000030.1:10551151-10576296[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 6.6e-71 1.9e-67 225.7 1.0 1 125 13 134 13 134 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	6.6e-71	1.9e-67	225.7	1.0	1	125	13	134	13	134	0.99

Sequence Information

Coding Sequence: ATGGAACGTCACCAAAATGGTATGGATGTGTGGGTAGGGCAAGGTAGAGTCAACCAGCTGGGTGGGTTGTTCATCAACGGTCGGCCGCTACCCAACCACATCAGGCTGAAGATCGTTGAGATGGCGGCGGCGGGAGTGCGGCCCTGCGTCATCTCGCGCCAGCTGCGCGTCTCGCACGGATGCGTCTCCAAGATACTCAATAGATACCAGGAGACGGGTTCAATAAGACCGGGCGTTATCGGCGGATCCAAGCCCAGGGTGGCAACCCCTGAAGTGGAGGCAAGGATAGAAGAGCTTAAGCGACAAAATCCGGGCATATTTTCTTGGGAAATCCGCGAAAAGTTAATTAAGGAGGGTGTGTCTGATCCGCCAAGCATCTCTTCAATATCGCGTCTACTTCGCGGCGGAGCAAGAGATCCTGATGGCAAAAAGGATTACAGCATCGATGGAATACTTGGAGGTCGGGGTTCAGACTCTTCAGACATCGAATCTGAACCGGGACTAACATTGAAAAGAAAACAGCGGAGATCCCGTACCACCTTCACCGGCGAGCAGTTGGATGCCCTTGAACGAGCTTTCCATCGAACGCAGTATCCAGATGTATACACTAGAGAAGAACTGGCTTTGCAAACTGGTCTTACTGAAGCCAGGATACAgGTTTGGTTCTCCAATAGACGGGCGAGACTTCGAAAACACACCGGTTCGAATTCAGCACCAACTCTAGCAAGTTACTCTACACTACCTATGCCCCAGATACCTTGTCCATATCCCGCAGGAGATATTCCCTCTCTTGCTCAACATCACCCACAACACCCCGATGCATGGCATCATCAAAAATATGCAAATTACAACCAATTAATGGCGCAATCGCAACATTTGAATCAAGCATTCCAAAGCGCTGCTTTTCCCAGTACTTCTGGCTCTACTTTTAGTCATTTAGTCAGCAGTGCGAATGGACCACACAGTCAATTATTGGATGCCACAGTACCTAGAAATGACTATGCCCGATACCCCAACCCtgatgtttataataaaactatcaATTATCTACCCAAAGACACCGATGTTGACGATAAAGTCATCGCTGAAGAAGTCATTGAACCACGCGAAGACGCCTATGTGAAAACTAATCCTAGTGAATATAAAGAGTTACCAAATAATGAGTACCCTAAAGTTCCTACTGATTATTCTAAAGTAGCTGTAGACCCTTCAGTGACTTCCAACTGGAGTCCATCCCATAACTCTTTAAATATGAGCCTAGCGGGACTTTCGagtgaatataaatatatgaacGATCCATATGCTTTCCCCAACATAGCTGATCCATTGAATCAGCATGGATATCCTAATCCACCTAATGCGGGCAACAAATATTggatttga
Protein Sequence: MERHQNGMDVWVGQGRVNQLGGLFINGRPLPNHIRLKIVEMAAAGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRVATPEVEARIEELKRQNPGIFSWEIREKLIKEGVSDPPSISSISRLLRGGARDPDGKKDYSIDGILGGRGSDSSDIESEPGLTLKRKQRRSRTTFTGEQLDALERAFHRTQYPDVYTREELALQTGLTEARIQVWFSNRRARLRKHTGSNSAPTLASYSTLPMPQIPCPYPAGDIPSLAQHHPQHPDAWHHQKYANYNQLMAQSQHLNQAFQSAAFPSTSGSTFSHLVSSANGPHSQLLDATVPRNDYARYPNPDVYNKTINYLPKDTDVDDKVIAEEVIEPREDAYVKTNPSEYKELPNNEYPKVPTDYSKVAVDPSVTSNWSPSHNSLNMSLAGLSSEYKYMNDPYAFPNIADPLNQHGYPNPPNAGNKYWI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00942658; iTF_01495631; iTF_01129990; iTF_00197223; iTF_00932263; iTF_00026696; iTF_00889033; iTF_00932490; iTF_01115562; iTF_01115658; iTF_00195019; iTF_01129901; iTF_00197329; iTF_00931282; iTF_00957810; iTF_01494166; iTF_00195128; iTF_00931068; iTF_01494268; iTF_01494908; iTF_00957917; iTF_00889183; iTF_01495007; iTF_01495744; iTF_00114913; iTF_00114789; iTF_00770951; iTF_00771048; iTF_00119457; iTF_00661249; iTF_00632611; iTF_00662086; iTF_00737318; iTF_01529158; iTF_00638503; iTF_01170567; iTF_00686312; iTF_00686186; iTF_00737450; iTF_00661132; iTF_01171437; iTF_00119566; iTF_00662192; iTF_01529042; iTF_00638612; iTF_01219636; iTF_00632725; iTF_01170423; iTF_01171319; iTF_01099707; iTF_01099803; iTF_01219739; iTF_00810849; iTF_01509573; iTF_00810997; iTF_01509431; iTF_00698242; iTF_00704802; iTF_00698121; iTF_00699948; iTF_00701004; iTF_00701804; iTF_00702861; iTF_00701937; iTF_00699026; iTF_00704979; iTF_00702740; iTF_00700085; iTF_00696345; iTF_00700857; iTF_00696444; iTF_00699136; iTF_01161163; iTF_01161320; iTF_00705971; iTF_00705837; iTF_00044468; iTF_00044308; iTF_00909594; iTF_00909680; iTF_00406561; iTF_00836369; iTF_00836529; iTF_00406710; iTF_00407417; iTF_00407547; iTF_01202433; iTF_01206402; iTF_01205668; iTF_01204006; iTF_01203207; iTF_01205549; iTF_01202320; iTF_01204851; iTF_01203893; iTF_01206517; iTF_01203096; iTF_01204728; iTF_01247937; iTF_00934727; iTF_00164170; iTF_00164333; iTF_00934588; iTF_01248094; iTF_00786754; iTF_00288707; iTF_00288839; iTF_00786618; iTF_00403613; iTF_00403775; iTF_00687749; iTF_00687843; iTF_00933580; iTF_00933724; iTF_00358370; iTF_00358530; iTF_00710984; iTF_00710032; iTF_01561872; iTF_01193457; iTF_00357458; iTF_01561973; iTF_01193560; iTF_00357274; iTF_00710171; iTF_00710877; iTF_01141506; iTF_01141507; iTF_01142967; iTF_01141624; iTF_01143064; iTF_01141625; iTF_01542796; iTF_01544716; iTF_01544844; iTF_01546480; iTF_01542934; iTF_01543735; iTF_01546615; iTF_01543901; iTF_01140884; iTF_01138913; iTF_00072578; iTF_01140168; iTF_01148778; iTF_01140076; iTF_01142254; iTF_00072784; iTF_01148688; iTF_01149554; iTF_01144403; iTF_01142357; iTF_01145238; iTF_01149430; iTF_01140792; iTF_01145145; iTF_01144506; iTF_01147258; iTF_01138812; iTF_00033667; iTF_00926439; iTF_00033772; iTF_00926574; iTF_00032880; iTF_00206960; iTF_00032756; iTF_00142937; iTF_00143035; iTF_00206845; iTF_00835401; iTF_00837322; iTF_00834604; iTF_00834477; iTF_00835565; iTF_00837504; iTF_00825436; iTF_00825703; iTF_00856451; iTF_01428902; iTF_00267152; iTF_00856593; iTF_00377074; iTF_01429013; iTF_00376952; iTF_00267033; iTF_00361465; iTF_00361595; iTF_00971076; iTF_00887375; iTF_01359568; iTF_01437816; iTF_01437944; iTF_00887260; iTF_00971197; iTF_00353029; iTF_00353928; iTF_00354043; iTF_00352892; iTF_00819909; iTF_00063553; iTF_00341185; iTF_00063426; iTF_00787618; iTF_01197571; iTF_00706788; iTF_00341285; iTF_00290662; iTF_00822982; iTF_01010214; iTF_01502056; iTF_01075401; iTF_01166665; iTF_01489993; iTF_00820042; iTF_00235723; iTF_00427947; iTF_00787467; iTF_01166444; iTF_01360460; iTF_00706925; iTF_00908813; iTF_00858510; iTF_00859311; iTF_01429903; iTF_01490095; iTF_00636368; iTF_01501936; iTF_00235826; iTF_00290514; iTF_00637330; iTF_00428083; iTF_00637619; iTF_00157173; iTF_00441333; iTF_00441461; iTF_01075221; iTF_01010326; iTF_00822743; iTF_01429784; iTF_00819001; iTF_00908666; iTF_00858395; iTF_01197691; iTF_00157052; iTF_00819132; iTF_00636125; iTF_00859421; iTF_00275233; iTF_00844165; iTF_01403400; iTF_01500952; iTF_00844313; iTF_01403290; iTF_01501083; iTF_00275102; iTF_00123202; iTF_00123340; iTF_00122358; iTF_00124088; iTF_00124220; iTF_00121247; iTF_00121407; iTF_00122207; iTF_00947747; iTF_00431978; iTF_00947855; iTF_00432120; iTF_00432985; iTF_00433115; iTF_00282116; iTF_00281222; iTF_00282311; iTF_01360583; iTF_00280981; iTF_01340068; iTF_01339811; iTF_01119301; iTF_01118282; iTF_00111630; iTF_01118101; iTF_00111449; iTF_01117019; iTF_01117181; iTF_01119135; iTF_01025830; iTF_01028258; iTF_01029063; iTF_01026152; iTF_01028110; iTF_01029237; iTF_01363080; iTF_00120481; iTF_00176961; iTF_00237313; iTF_00273569; iTF_00425345; iTF_01064481; iTF_01439905; iTF_01440833; iTF_00043458; iTF_00172578; iTF_00445954; iTF_00709026; iTF_00745474; iTF_00809090; iTF_00363875; iTF_00450083; iTF_01062627; iTF_01338723; iTF_01377443; iTF_00147428; iTF_01338340; iTF_01362404; iTF_00375173; iTF_00447109; iTF_00000166; iTF_00147142; iTF_00425222; iTF_01084102; iTF_00042599; iTF_00667431; iTF_01093063; iTF_01527143; iTF_01534791; iTF_00001032; iTF_00043336; iTF_00327048; iTF_00907016; iTF_01094888; iTF_01377320; iTF_00185161; iTF_00831017; iTF_01425033; iTF_01564393; iTF_00017194; iTF_00785162; iTF_00907850; iTF_01063722; iTF_01532874; iTF_01342187; iTF_00042476; iTF_00071244; iTF_00905964; iTF_01221516; iTF_00000301; iTF_00622797; iTF_01062765; iTF_00018030; iTF_00071406; iTF_00120334; iTF_00375022; iTF_00907726; iTF_01061838; iTF_01533902; iTF_01564622; iTF_00038735; iTF_00041743; iTF_00374063; iTF_00449967; iTF_00711663; iTF_01285391; iTF_00036656; iTF_00040784; iTF_00172880; iTF_00810032; iTF_00928656; iTF_01063600; iTF_01085168; iTF_01531984; iTF_00038545; iTF_00449073; iTF_00709201; iTF_01487569; iTF_01533777; iTF_01534641; iTF_00446962; iTF_00711826; iTF_00809906; iTF_00924626; iTF_01342066; iTF_01526866; iTF_00007059; iTF_00177075; iTF_00445139; iTF_00726131; iTF_01246675; iTF_00273460; iTF_00301140; iTF_00446100; iTF_01064628; iTF_01246868; iTF_01362324; iTF_01487668; iTF_00274293; iTF_01525781; iTF_00006934; iTF_00906902; iTF_01092918; iTF_00018135; iTF_00037623; iTF_00037783; iTF_00326935; iTF_01094007; iTF_01533015; iTF_01538583; iTF_00001144; iTF_00039640; iTF_00726328; iTF_00924440; iTF_00928504; iTF_01441016; iTF_00036473; iTF_00808953; iTF_00906105; iTF_00041626; iTF_00274394; iTF_00301018; iTF_00685274; iTF_01093882; iTF_01439738; iTF_01538714; iTF_00017307; iTF_00301947; iTF_00363995; iTF_00745659; iTF_00785051; iTF_01084987; iTF_01094747; iTF_00039772; iTF_00302076; iTF_01424892; iTF_00444957; iTF_00667197; iTF_00185278; iTF_00373758; iTF_00040639; iTF_00185983; iTF_00622655; iTF_00685407; iTF_00831167; iTF_01221343; iTF_01285503; iTF_00237536; iTF_00448864; iTF_01061728; iTF_01084224; iTF_01362944; iTF_01525984; iTF_01531808; iTF_00783433; iTF_00784361; iTF_00783280; iTF_00784244; iTF_01090729; iTF_01090534; iTF_00771723; iTF_00300001; iTF_01030978; iTF_01030180; iTF_00300169; iTF_01031113; iTF_01192682; iTF_00888237; iTF_00771886; iTF_01027150; iTF_00850447; iTF_01230543; iTF_00851570; iTF_00850708; iTF_00952693; iTF_01027286; iTF_00951639; iTF_01030007; iTF_00951800; iTF_01192472; iTF_01230361; iTF_00851770; iTF_00952541; iTF_00888063; iTF_00113292; iTF_01316322; iTF_01317124; iTF_01316170; iTF_00112363; iTF_01317260; iTF_00112462; iTF_00113970; iTF_00114070; iTF_01312088; iTF_00113181; iTF_01312192; iTF_00383472; iTF_00186146; iTF_00383621; iTF_00677584; iTF_00677389; iTF_00758128; iTF_00757988; iTF_01358737; iTF_01358839; iTF_01222322; iTF_01222445; iTF_00635379; iTF_00635245; iTF_01491731; iTF_01491907; iTF_00077333; iTF_00077450; iTF_01264245; iTF_01264584; iTF_00827927; iTF_00827824; iTF_00461528; iTF_00960131; iTF_00418820; iTF_00842500; iTF_01033700; iTF_01033573; iTF_00958632; iTF_00418954; iTF_00842634; iTF_00959370; iTF_00958542; iTF_01034382; iTF_00960017; iTF_00421204; iTF_00421302; iTF_00461405; iTF_01034557; iTF_00959263; iTF_00794168; iTF_00794569; iTF_01332600; iTF_01332392; iTF_01436056; iTF_01435909; iTF_00821625; iTF_00821780; iTF_01152123; iTF_01151917; iTF_00404540; iTF_00404879; iTF_00967996; iTF_00967898; iTF_00715645; iTF_00715757; iTF_00823870; iTF_00823774; iTF_00869470; iTF_00869597; iTF_01156133; iTF_01157512; iTF_01157704; iTF_01153705; iTF_01155146; iTF_01158925; iTF_01154865; iTF_01153945; iTF_01156409; iTF_01158556; iTF_00720261; iTF_00011792; iTF_00720049; iTF_00011955; iTF_00146392; iTF_00146240; iTF_01385541; iTF_01388302; iTF_01386674; iTF_01388435; iTF_01385722; iTF_01386559; iTF_00878821; iTF_00878723; iTF_01173127; iTF_01076459; iTF_01073581; iTF_01073455; iTF_01076239; iTF_01180178; iTF_01180275; iTF_01173243; iTF_01179355; iTF_01179455; iTF_00744455; iTF_01178532; iTF_01178250; iTF_00744604; iTF_00752039; iTF_00751876; iTF_01151176; iTF_01151078; iTF_00953482; iTF_01080578; iTF_00695331; iTF_01507011; iTF_01506308; iTF_01018533; iTF_00806536; iTF_01091880; iTF_01401130; iTF_00806699; iTF_01078924; iTF_00642285; iTF_01080685; iTF_01401261; iTF_01506189; iTF_01507918; iTF_00642191; iTF_01021040; iTF_01017585; iTF_01507185; iTF_01079027; iTF_01079859; iTF_00801655; iTF_00801816; iTF_01021176; iTF_00695514; iTF_01018426; iTF_01078172; iTF_01091549; iTF_01017695; iTF_01508031; iTF_00953376; iTF_01079744; iTF_00162729; iTF_00162345; iTF_00197961; iTF_00198087; iTF_01503849; iTF_01282241; iTF_00408423; iTF_00408239; iTF_01503695; iTF_01282072; iTF_00035631; iTF_00284513; iTF_00035491; iTF_00790090; iTF_00791043; iTF_00790230; iTF_00791162; iTF_01336810; iTF_01336677; iTF_00736588; iTF_01251592; iTF_01083152; iTF_00736470; iTF_01415673; iTF_01251707; iTF_01415803; iTF_01083294; iTF_00651714; iTF_00640289; iTF_00640125; iTF_00651584; iTF_00681507; iTF_00682215; iTF_00682377; iTF_00382570; iTF_00681614; iTF_00382419; iTF_00284373; iTF_00683285; iTF_00683168; iTF_00279081; iTF_00278961; iTF_01081557; iTF_01081435; iTF_01331273; iTF_01331464; iTF_00409130; iTF_00409249; iTF_00410122; iTF_00412362; iTF_00410253; iTF_00412476; iTF_00448106; iTF_00448005; iTF_01333772; iTF_01333577; iTF_00824560; iTF_00824705; iTF_01078044; iTF_01279221; iTF_01279114; iTF_00074327; iTF_00074478; iTF_01281307; iTF_01281155; iTF_00012988; iTF_00012787; iTF_00411262; iTF_00411414; iTF_01072286; iTF_01072465; iTF_00364767; iTF_00364892; iTF_00832895; iTF_00832754; iTF_00960895; iTF_00960784; iTF_01071488; iTF_01071592; iTF_01302304; iTF_01302139; iTF_01172172; iTF_01172329; iTF_00255853; iTF_00255724; iTF_00875277; iTF_00875154; iTF_00874301; iTF_00874430; iTF_00896621; iTF_00896776; iTF_00985069; iTF_00984873; iTF_01082285; iTF_01082408; iTF_00161390; iTF_00161513; iTF_00468039; iTF_00468141; iTF_00723821; iTF_00723924; iTF_00075311; iTF_01124451; iTF_01125295; iTF_01124562; iTF_00076499; iTF_00075479; iTF_00076311; iTF_01125434; iTF_00405871; iTF_00405773; iTF_00994320; iTF_00994215; iTF_00935697; iTF_00935523; iTF_00125096; iTF_00390338; iTF_00895910; iTF_00649063; iTF_00913576; iTF_00250313; iTF_00649869; iTF_00913454; iTF_01209230; iTF_00125007; iTF_00390225; iTF_00895762; iTF_00649976; iTF_00250426; iTF_00648955; iTF_01209051; iTF_00674258; iTF_00674153; iTF_00321555; iTF_00321447; iTF_00323475; iTF_00323335; iTF_01367540; iTF_01367873; iTF_00212277; iTF_00212424; iTF_00774359; iTF_00457092; iTF_00777349; iTF_00775112; iTF_00722892; iTF_00782604; iTF_00621197; iTF_00457198; iTF_00248047; iTF_00780113; iTF_00247890; iTF_00775219; iTF_00621076; iTF_00723028; iTF_00247029; iTF_00247159; iTF_00777272; iTF_00780217; iTF_00774458; iTF_01181754; iTF_00159804; iTF_00782492; iTF_00159679; iTF_01181855; iTF_00055382; iTF_00055244; iTF_00647958; iTF_00647846; iTF_00213271; iTF_00213412; iTF_00430615; iTF_00430475; iTF_00634455; iTF_00634164; iTF_00354936; iTF_00355118; iTF_00662936; iTF_00663042; iTF_00925688; iTF_00925579; iTF_00027609; iTF_00026817; iTF_00027713; iTF_00150329; iTF_00150500; iTF_01443802; iTF_01443684; iTF_00855739; iTF_00855853; iTF_01182523; iTF_01182835; iTF_00025212; iTF_00025116; iTF_01341245; iTF_01340988; iTF_01547517; iTF_01547370; iTF_00673470; iTF_00673346; iTF_01335902; iTF_01335780; iTF_01502942; iTF_01502824; iTF_01561086; iTF_01560967; iTF_00177920; iTF_00178126; iTF_00277216; iTF_00277315;
90% Identity: iTF_01415803;
80% Identity: iTF_00942658;