Basic Information

Transcription Factor Domain

TF Family: AF-4
Domain: AF-4 domain
PFAM: PF05110
TF Group: Unclassified Structure
Description: This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 9.4e-07 0.025 14.4 0.1 44 119 13 90 8 116 0.72

2 3 0.076 2e+03 -1.8 0.2 455 476 126 147 101 150 0.70

3 3 1.8e-06 0.046 13.5 0.1 323 381 165 224 161 237 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	9.4e-07	0.025	14.4	0.1	44	119	13	90	8	116	0.72
2	3	0.076	2e+03	-1.8	0.2	455	476	126	147	101	150	0.70
3	3	1.8e-06	0.046	13.5	0.1	323	381	165	224	161	237	0.80

Coding Sequence: ATGGGTACGGATCAGAAAGTTAATCCGGATTCTCAAGATCGGACTACCCAACAGATACAATCAAAGTTGGGTAATTATTCCCTGGTAAAACACCTACTGGATGAACCGAAAAGGCTGATTGGAATCGAAGGTGTACCCCCAAGTCCGGCTCCTTTAGCTCAACGTAAGCCAGTTACACAAGAATTTAAAAAGCCTGGAGGACCTCGTCCGAATTCAAGCAGTACACACGGCTCTCAAAATAGCGGTTACGTTAAACCAGCCGATGGCAAACCGCCCTATATGGGAAGAGGTGGTTATCCTGGTCAACCGGTCAAGCACGGTGGTGGCAGTAATGATCATCGAAGTCACGGTCTTCTGCCAGCTAAAGGTCCTCCTAATCCTGCATctagaggaggaggaggaggaagtggaagtggaagtggaagtggaagtggaagtaaCGGAGGAAATAACGTCGGTGTAGGGGGAGTAGGAGCAGGAGGAAGATTGCAAAACGCAGGAAGTCATCTCTCCAGATTACCTATGGACAACGGTGCAATGTCCCGGCATTCCGCGACCGAGAATGCCGCCGACTTGGACAACATTCTTAAGGAGATGGCGCTTCCCATCACACCACTGACAGCTATAGCCCAAACCCCACGCAAAGAACCTGAGTCAAAATTTACCTTCAACCCGTACCTCGCCAAGctgaCTGAAGTCCCTCAACCAGAGCCCGCCAAAACTCGTGAGTACATTTACTTTTACCTtaaGATGGTTTCCATGGATACGCCACCCGGAGCTCAGCATCTGTACAACCTCTTAGCCATCTCTATGGATATAACCGACGAAAATCCACCGTGTTAG
Protein Sequence: MGTDQKVNPDSQDRTTQQIQSKLGNYSLVKHLLDEPKRLIGIEGVPPSPAPLAQRKPVTQEFKKPGGPRPNSSSTHGSQNSGYVKPADGKPPYMGRGGYPGQPVKHGGGSNDHRSHGLLPAKGPPNPASRGGGGGSGSGSGSGSGSNGGNNVGVGGVGAGGRLQNAGSHLSRLPMDNGAMSRHSATENAADLDNILKEMALPITPLTAIAQTPRKEPESKFTFNPYLAKLTEVPQPEPAKTREYIYFYLKMVSMDTPPGAQHLYNLLAISMDITDENPPC

Sequence clustering based on sequence similarity using MMseqs2