Sumb001268.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Synergus umbraculus
Gene Symbol
MBD-R2
Assembly
GCA_900474325.1
Location
UCOK01006156.1:10628-14182[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 4e-16 2.7e-12 46.7 0.2 6 69 394 457 389 465 0.91

Sequence Information

Coding Sequence
ATGTCAATGAAATCTCCCACATCTTATTCTCAAGAAGACTTGGACTTGATAAATTCAGAAATCCCCAGTTTCGTTAATTCCATCCCCACTACTTCTTCTGATCAAGCTCAAAAATCTTCTGCAAATACTGGCACACATTTCCCCAATGTAGAAGAATCcccaaataatttaaataccttAATTATCGACGATTTGCACAATGCTTGCAGCCTCGAGTTAAACAAAGAAGTATCTGCAGCAGAGAAAAACGAGTTCATCCAAAATGAAAATGTGGCAATTCCAGACGAAGCTGTTCAAAAAATTGCCAATCTCCCTGTGATTGTAGATGATGCTACAAAAAACTTTCATCAAGGAATCGAGAACATCAGACTGCAGAGTGAgaggaaaatcgaaaaagaaaACGAGCTGAAAACCAAATCCGTGAATCGAAGGGGTTTAAACTTTTCACCAGGTGACAAACTTGAagcaaaggattttaatgaaaaatggtatTCAGCTCGAGTAGTTGAGACCGACTGGGTTGAACGGGAAGTCTTGATTCATTTCGATAAATGGAGTTCCAGATTTGACGAGTGGATTCCTATGGACAGCCCTCGTTTGCGAGTTTTACAGGTTCAATCGCGTGAAATGAAAACGAGAGATTTCGTAGCGGGGGAGAGAATTCTAGCTACCTGGGCAGACGGTAGAAAGTATCCAGCGAAAGTAAACGCTGTCTTAGGAAATGACAGATACGACGTTCATTTCGACGATggatacgtaaaaatcattagatCCTCCAAAATGACCAAGATTGGAGGACCTTTGGAAGAGGAAATTGATGGTGAAGACATCATTGGAAGTAAGGAGAAACgaaaggatagaaatcgaAAGTACCAAGTGATGGACCTCTTCCAAAGGAAATCAAAAAAACTGAATCCCAGGAAGGGTCGACCTGGCAAAGAGGGACCTAGTGAACCATTACTAGCCGAGAGTGAATCTCCATCGGGATCTCACGACGATTCTGGCACCGAGGTTCTGCACGGATTTGATAATTCAACTCCGAAGGTTAAGacatatttaaagaaagacaaaaaggaaaaaaccGACGCTGAGCTCGAAGAGAGCGTTAGACCTGAATGGATAGATGGAGAACCACAGGGAATAGAATCCTACATCGAAGGACCTCGTCGCTCCATAATTGTAGCTGATAAACGCTTACCACCAGGTTGGCAGAAGCACTTTACTCAGCGGAAGGCGGGATCATCTGCTGGAAAATGGGACGTGCTTTTTATACACCAATCAAGTGACAAGAAATTCAGATCTAGAAATGACATCAGAAGCTATATGGCGACTCAAGGTATGATGGACTTCGATCCGGAGAAATTTGACTTTTGCATCCATCGAAAGAAAAAGACCAAGCTAGAGAAACCAAAGAGCGAAGCTGATCCtgtcaaaaaaccaaaatcTCATTCGAGAGCGAAACATACTCTTGTTCCTGAATATTCGCCGGTTCCTGGTTTCAGTACTCCGACTTCTTCAATGACACCATCTTCGTCAGTGGATGACGGAGCAGTTTTCATCGGAGACCTGCGGATAGAAATGGAGGACAGTTCCTACAAGTGTCCTAAAGAGGGTTGCTTGAAGAACTTTAGGAAGGAAAATCTCCTGCAAATGCATATAAAACACTATCACCCTGAGTACTCGAAATTCCTGGGTTCAACACCTAATGTTGCAGACTTAGCGTATGCGAGAACCATTGGAGAATCGATCGGTGATATCATCCCGAAGCAGACCTCTAACTTCATGGAGAAGATAAACAAATTTGAGAGGAGAAAAGGGTCACATGATAAGTCTCAGTTGCCGGTTTTGCACTCGGCACTCTCGCCTTCCCAATTGTTGTCGACTTCAATGCCATCTCCAACACCTCCGGTGTTGGAAGTCGAAGTCGGTCGACCTGAGGATTTGAGCAATTTCCAGAGGGAAGAAAAACTCGAACTGGGATCTCCAGTCAGAGGTAATAACGAGAATGCTAGGCAAGATAACGACTGTGCTATGTCCCCTGGAACCCTTTTCGACTTGAAACTTCGCGAGGAGAAAACACAGACTGGTATCAAAACTCTTCTACCAGTTAGATCAGCAGTATCAGAACGGTTGGATAAATCCAAGTCTCTGGAAGAGGCCGCTCGGAAAGAGAGAGGACGGAGCCAGAGAAAACGACATATTTCGGATTATCAGTCAGACGTGGTTGGCAGatcgaaaaagaagaatattgCACAAGATTTGTCAGAGAGCATTGATGAGACACCTTTAAATACTACAGATCCAGAAGGCCGTCCGACAGCGTATCGTTTCAGTCGGAGGAAACTGGTGGGCTCGAAACACAGCGGCATCGTTAAGAATAAGAATGGAGAGATGACTATGTTGATAAACGGTGAAGTGATCAAAGTAGAGCAGCTTCGTAAGGAAGAGATCATTAACTGCACATGCAAGGTGGTAGAAGAGGATGGTTTGATGATACAGTGCGATCTTTGTCTTTGCTGGCAGCATGGACACTGTAACGCGATTGAAAAGGAACAAGACGTCCCTGATAAATACGTTTGTTATATTTGTCGACATCCTTACCGACAACGACCgtcgaaaaaatatatccaTGACCAGGAGTGGATGAAGACAGGTAAACTGCCAAGTCTCCCTGACCGGACGAAGAACGAACTTACGATCCAGCAAAGATCAGCAATGCTGAAACGCTCCTGCGATTTAGTGTCTTCCTTACTTCAGATTCAAACTCTACTTCACAGCTTACGAGTCAAGATTAATGTCGCTCAGAAGAAAGACCATCCTAAGTTGTATCTTTGGGCGAAAAATTGGGAGAAATCTGTGATTCCAAAGCCTGATATTACACCAGTTCCtgttcttgaaatttctgaaaatgttgATGAACCGGATATTAAATTGGATAAGGAAGAAATTAAGTTGGAGGATCGAAGTATCAAGGAAGATCCAGATGATAAATCAATAACGACTGATTCTGAGTTGGTGAAGATTCTAGAGGAGGATGGGACACATTCTGAGGAGTCGAAGGTTGTaaacaaagtagaaaattcTGTGAGtcaaaatgatcattttctgCTGGATGCCTTGACAAAGAGCACTACTCtggaagaaaatttgaaaacagagACTTCTAATGACATTTTAGATAACCAAGTTGCCAAGAAAAGTACAAATGTTGAAACGAAATCGGGCGTTTTGTCTGAAAATGGCATTTCGACTCAAGCAGAGTTTTCCTCGCCTCAGACTAAACATTCTGTTGCTCTACCTTCGCAACCATTTATTCCGGAACCGGAAGCTCCAATTGATCCTACAGAATGCAGAATGAGACTGTTGGAACATGTTGATCACTATGAAAGTTATGTTTCTTCAACATTAACATCCATTGAAGCCCAAGTTCAGGCTTTAGAAGAAATGGACCCTGATCTGACGCCAGAATTAGATATTCATCCTCGGACTAAACAAACTGTGCAAATGTTGCTTAGAGACTTGAGTACAATCAGAAAACTTGCAGcgatttgttaa
Protein Sequence
MSMKSPTSYSQEDLDLINSEIPSFVNSIPTTSSDQAQKSSANTGTHFPNVEESPNNLNTLIIDDLHNACSLELNKEVSAAEKNEFIQNENVAIPDEAVQKIANLPVIVDDATKNFHQGIENIRLQSERKIEKENELKTKSVNRRGLNFSPGDKLEAKDFNEKWYSARVVETDWVEREVLIHFDKWSSRFDEWIPMDSPRLRVLQVQSREMKTRDFVAGERILATWADGRKYPAKVNAVLGNDRYDVHFDDGYVKIIRSSKMTKIGGPLEEEIDGEDIIGSKEKRKDRNRKYQVMDLFQRKSKKLNPRKGRPGKEGPSEPLLAESESPSGSHDDSGTEVLHGFDNSTPKVKTYLKKDKKEKTDAELEESVRPEWIDGEPQGIESYIEGPRRSIIVADKRLPPGWQKHFTQRKAGSSAGKWDVLFIHQSSDKKFRSRNDIRSYMATQGMMDFDPEKFDFCIHRKKKTKLEKPKSEADPVKKPKSHSRAKHTLVPEYSPVPGFSTPTSSMTPSSSVDDGAVFIGDLRIEMEDSSYKCPKEGCLKNFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESIGDIIPKQTSNFMEKINKFERRKGSHDKSQLPVLHSALSPSQLLSTSMPSPTPPVLEVEVGRPEDLSNFQREEKLELGSPVRGNNENARQDNDCAMSPGTLFDLKLREEKTQTGIKTLLPVRSAVSERLDKSKSLEEAARKERGRSQRKRHISDYQSDVVGRSKKKNIAQDLSESIDETPLNTTDPEGRPTAYRFSRRKLVGSKHSGIVKNKNGEMTMLINGEVIKVEQLRKEEIINCTCKVVEEDGLMIQCDLCLCWQHGHCNAIEKEQDVPDKYVCYICRHPYRQRPSKKYIHDQEWMKTGKLPSLPDRTKNELTIQQRSAMLKRSCDLVSSLLQIQTLLHSLRVKINVAQKKDHPKLYLWAKNWEKSVIPKPDITPVPVLEISENVDEPDIKLDKEEIKLEDRSIKEDPDDKSITTDSELVKILEEDGTHSEESKVVNKVENSVSQNDHFLLDALTKSTTLEENLKTETSNDILDNQVAKKSTNVETKSGVLSENGISTQAEFSSPQTKHSVALPSQPFIPEPEAPIDPTECRMRLLEHVDHYESYVSSTLTSIEAQVQALEEMDPDLTPELDIHPRTKQTVQMLLRDLSTIRKLAAIC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01390215;
90% Identity
iTF_01391975; iTF_01390215; iTF_01391104; iTF_01392770; iTF_01389428; iTF_01393520;
80% Identity
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