Basic Information

Gene Symbol
wek
Assembly
GCA_900474275.1
Location
UCOH01012691.1:3328-6659[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 3.3 3.4e+02 2.4 0.2 2 23 149 171 148 171 0.80
2 15 0.00031 0.032 15.1 0.3 2 23 176 198 175 198 0.91
3 15 0.34 35 5.5 0.6 2 23 380 401 379 401 0.96
4 15 0.44 46 5.2 0.1 2 23 407 429 406 429 0.94
5 15 0.00013 0.013 16.3 0.5 1 20 439 458 439 459 0.95
6 15 6.7e-05 0.0069 17.2 6.2 2 23 470 491 469 491 0.98
7 15 0.00075 0.077 13.9 1.1 1 23 504 526 504 526 0.98
8 15 9.8e-05 0.01 16.7 0.4 1 23 534 557 534 557 0.97
9 15 0.0001 0.011 16.6 2.9 1 23 563 585 563 585 0.94
10 15 0.00062 0.064 14.2 2.5 1 23 588 611 588 611 0.95
11 15 0.016 1.7 9.7 1.0 1 23 630 652 630 652 0.96
12 15 0.00015 0.015 16.1 2.8 1 23 658 680 658 680 0.98
13 15 1.1e-06 0.00011 22.8 0.8 1 23 685 707 685 707 0.97
14 15 9.6e-05 0.0098 16.7 5.1 1 23 715 737 715 737 0.98
15 15 4.3e-05 0.0045 17.8 0.8 1 23 743 765 743 765 0.98

Sequence Information

Coding Sequence
ATGGACGTGGAAGCAATACCGGACGAAAgagtGGGTTCACAGCCATTCGAAGAGAATATAGAAGAATTATGTCGATTGTGTGGACAGGTTTACGAAACTTCCGTATCAATATTCGACAACAAATTGTCAGTTGCTGAGAAAATCAGCAGATGTCTACCAATAATTgTTGTTGCCAATGATGACTTGCCCTCACAAGTCTGTACGCAATGTTACGCGTACTTAAATATCAGCTACAAGTTGATTGTGAActctataaaaattgatacttttctgcgaaaaaaattacaaaaaagtaaCATGATTAAGAGAAATGAAGCAAAtagtaaagaaattgaaaacagTACAGAAACTGCAAAGAATTCTGAATCTGATTTAATATCAAATGAAGAAGCCACTGTTGTGCCAATAAAgaagttaaagaaaattgcGATTCACGGTCCTGTTACCTGTGAGTTCTGTAACCTGGTGTTCGATGAAGTTAATGAATTTGATGAACACTTCGAATCCAATCACATTTTGAAGTGGAAATGTAATTTCTGTGACGAAAGTTTTCAAACATCTGATGAGCTGATTACACATAAAGCATTGATGCATGCTGGAAATATAATCATCTGCAAAGCTTGTGTAGATGAAGAGACGAATATAGGCCAGAAAGAACCAAAAATTGAAGATGACAATTTCTCTTCTGACGAGGAACGCGAGGATAAATTCGACATACCCGCGGAATCTGCGTTACCTGATACtccttctattttaaaatcagcTCTAAATCGTCCAACTGAAACTTCTAGCGATCAATCCTTTGTGACTCCTACCACTTCGAATTCGAAAGAAGTTGAAAATactaaatcttcaaaaatgttACCAGCAACTTTAATTGTTTCTCCAGCTTTGACTTCAAAGTTTCTCTACGGCACAACCGGTAGTACAAGTAAAGGTGctgcaaaaattgtttttggtTCTGGTGAAAATTCTGAATCTTCATCTATAAACAGCAGTGTACCATCCACACCTTCGCCTAGTACATCTAAACTAGGTAGGAACCCTTCTGTTGCCAAGTTAATTAAAACAGTGAGATTTGCGATGAATGAAAAAGTAGATAGAATAAGAGCCAACGAAAGAGCTAAGACTTGCATGTCTTGCGATGTGTGCCACCTTCAAGTAGATGATCAAAAACTCTTTGATCTCCACCAAAATATCCATTCACCGAAGTCTATGGTGTGCGATCTGTGTAAATTGGTGTCTCCAACCATTTACGATCTTTATCTTCACAAACGAGAAGCTCACAATCTCTTCACGAAAGTTAATCTCAAATACGTTTGTGACAAATGcggaaaattcttttctaacaGCTGGCAGTGGGAGACACACAAATCTTGCAGATGTAAAAACAaagaaagtgaaaataaatgcaaataCTGCGAATCTTCATTCTCCACGAGCCATAAGCTAAAACGACATTTGAGGaAACATAAAGACGAGATGATGAAAGATCCCGAAGTTGAACCATTCAGATGTGTTTCATGTCCTAAAGTTTTTTATGAtgaagaattttatcaaaaacatagaaacGTTCACGATCCAGAATGCTGGAACAACTTCAAATGCAACGCTTGTGACAGATCTTTTAGAGATGCTGTTAGACTAAAAGAACACGTGAAATCGATACACGAAGGGATAAAGCCACACGCTTGTGATATGTGTGGCAAAACTTTCCACCGTTTGTCGAATatgaaagtaCATCGAGCGTTACATTTTGGTCATAAGTGTACTCACTGTGATCAAGTCTTTGAAAAGGTGCGTCAGTTAGTGACACACATTCAAGAAGATCATGGTTTGGAGCCACCAGCTAGCTTGACTGCTAAGAAAGGATATGTGAGCGGAACTTACGTTTGCAGATTTTGTGGAAGGACTTTAGCAACTTACCAATCCTTGTTGGATCATGAGCACATTCACACTGGAGAAAAGCCTTATTCTTGTCATATCTGCGATAAAAGCTTCCGAAGCTACACGGCGCGCTGGTCTCACGTGCAAAGACATGAAACGGGAACTTTTATCTGTGAACAATGTGGCAAAAGTTTCAGTTTCAAGCAAAACTTAATGACACATGTGCAAATTCACGTCTCGATGGATGATCGAAAACATCAGTGTCAAGTATGtaagaaaaaattccttcgaaaggCGCATTTAAATATTCACATGCGCATTCACGATGGAGTTCGTCCCTACACGTGCGACATTTGCAATTTCAGTTTCACGCAAATCGGCGACATGAGAAGACATCGTGCTAGGCATGAAAATGGAACTGAAATGCGCAAGAGAACGCCACGAAATAGAACCGAGAACACCGCTGTCAAATCCGAAAACGTGACGTGGATTTCTGAAAGTAGCAACGAGGAGGACACTtcctaa
Protein Sequence
MDVEAIPDERVGSQPFEENIEELCRLCGQVYETSVSIFDNKLSVAEKISRCLPIIVVANDDLPSQVCTQCYAYLNISYKLIVNSIKIDTFLRKKLQKSNMIKRNEANSKEIENSTETAKNSESDLISNEEATVVPIKKLKKIAIHGPVTCEFCNLVFDEVNEFDEHFESNHILKWKCNFCDESFQTSDELITHKALMHAGNIIICKACVDEETNIGQKEPKIEDDNFSSDEEREDKFDIPAESALPDTPSILKSALNRPTETSSDQSFVTPTTSNSKEVENTKSSKMLPATLIVSPALTSKFLYGTTGSTSKGAAKIVFGSGENSESSSINSSVPSTPSPSTSKLGRNPSVAKLIKTVRFAMNEKVDRIRANERAKTCMSCDVCHLQVDDQKLFDLHQNIHSPKSMVCDLCKLVSPTIYDLYLHKREAHNLFTKVNLKYVCDKCGKFFSNSWQWETHKSCRCKNKESENKCKYCESSFSTSHKLKRHLRKHKDEMMKDPEVEPFRCVSCPKVFYDEEFYQKHRNVHDPECWNNFKCNACDRSFRDAVRLKEHVKSIHEGIKPHACDMCGKTFHRLSNMKVHRALHFGHKCTHCDQVFEKVRQLVTHIQEDHGLEPPASLTAKKGYVSGTYVCRFCGRTLATYQSLLDHEHIHTGEKPYSCHICDKSFRSYTARWSHVQRHETGTFICEQCGKSFSFKQNLMTHVQIHVSMDDRKHQCQVCKKKFLRKAHLNIHMRIHDGVRPYTCDICNFSFTQIGDMRRHRARHENGTEMRKRTPRNRTENTAVKSENVTWISESSNEEDTS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01389672;
90% Identity
iTF_01390547;
80% Identity
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