Basic Information

Gene Symbol
-
Assembly
GCA_945859765.1
Location
CAMAON010000077.1:577031-579022[+]

Transcription Factor Domain

TF Family
HMGA
Domain
HMGA domain
PFAM
AnimalTFDB
TF Group
Unclassified Structure
Description
This entry represents the HMGA family, whose members contain DNA-binding domains, also known as AT hooks due to their ability to interact with the narrow minor groove of AT-rich DNA sequences. They play an important role in chromatin organisation [1]. The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [2].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.0064 1.4e+02 2.5 3.2 11 16 13 18 11 19 0.82
2 4 1 2.1e+04 -5.1 1.4 12 14 33 35 33 35 0.91
3 4 4e-10 8.5e-06 25.5 2.2 4 21 55 72 53 73 0.87
4 4 0.63 1.3e+04 -3.9 6.9 10 15 84 89 83 90 0.83

Sequence Information

Coding Sequence
ATGTCTGATGATGGATCAACAGTTGTTGAGAAAAAAGGGCGCGGTAGACCAAAGGCTAATGGAACACAAACGGAAATCAAAGGTGATACAAAGAAAAGAGGCAGGGCCGCTAAACCTGAACCGACTAAAGCTAAGGAATCTGCGAAATCATCTGACGATGAACAAGCGCCAGTAGCGAAAAGAGGTCGCGGTCGACCAAAGGGCTCCAAGAAGAAAGCCGCCCCTAAAGCAAAGAGTGGAGGCGAAGGTCGTGGTCGCGGTAGGCCGCGCAAAGACGCACCGCCCAAGAAGGATGCCGCCTCCACGGAGGAGGAGCAAGAAGATGAGGATGAAGAAGAGGGCTCTGACCAGTAA
Protein Sequence
MSDDGSTVVEKKGRGRPKANGTQTEIKGDTKKRGRAAKPEPTKAKESAKSSDDEQAPVAKRGRGRPKGSKKKAAPKAKSGGEGRGRGRPRKDAPPKKDAASTEEEQEDEDEEEGSDQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00878866;
90% Identity
iTF_01388486; iTF_01387616;
80% Identity
iTF_01387616;