HMGA
- Domain
- HMGA domain
- Group
- Unclassified Structure
- PFAM
- AnimalTFDB
- Desciption
- This entry represents the HMGA family, whose members contain DNA-binding domains, also known as AT hooks due to their ability to interact with the narrow minor groove of AT-rich DNA sequences. They play an important role in chromatin organisation [1]. The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [2].
- Rederence
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- Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Tessari MA, Gostissa M, Altamura S, Sgarra R, Rustighi A, Salvagno C, Caretti G, Imbriano C, Mantovani R, Del Sal G, Giancotti V, Manfioletti G. Mol. Cell. Biol. 23, 9104-16, (2003).
- Evolution of high mobility group nucleosome-binding proteins and its implications for vertebrate chromatin specialization. Gonzalez-Romero R, Eirin-Lopez JM, Ausio J. Mol. Biol. Evol. 32, 121-31, (2015).
