Slit003997.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Spodoptera litura
Gene Symbol
HSFX4
Assembly
GCA_002706865.1
Location
NC:8853502-8855240[+]

Transcription Factor Domain

TF Family
HSF
Domain
HSF_DNA-bind domain
PFAM
PF00447
TF Group
Helix-turn-helix
Description
Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.5e-23 1.2e-19 70.5 0.1 1 100 21 121 21 121 0.87
2 2 0.49 3.9e+03 -1.7 0.1 40 56 125 141 123 180 0.79

Sequence Information

Coding Sequence
ATGTTAAAAATAGGTCTATCGAATATGCAAGACGACAGAAATGCTATATTCCAAATGCGTTTTCCTCAAAAACTGTGGTACTTACTAAATTTCCGCACTGATGCCATATTATGGGGTGGTACAGGACGAACAATTTTGTTGAATTATCGTATCCTTCATAACTACTTGCAATGTGATCactctatttttaaaacaacaaatatttcaagCTTTGTGCGACAGCTGAATCTGTATGGATTTCGAAAGGTCACTTCTCATTTGCAAGATCCTTTGTGTAATTCTAGCAACCCATACATGCATGAATATGTTCACGACTACTTTCAGTATGGTAAACCTgaattactgaataaaataacgCGTAAAGCTCTTGCTATGAAAAGAAATTTCAAACCTAAGaatctCTACAGTAACGTTGagcaattactttttttaacacCACTGCAAAAGGCAAGACGAGCTTTGCGCATGGCCCTAAAGAAAGCAGCTCAAGATTTATTTGTACAGAATTCACCTAAGCACTTTTGTAATCTTAAGTTTGAATGTGATGATTCTCAAGATGATTACTGTGAAgatgaagaaaatattgaatttgattggTTAATGACTAATGATGCCAGCACAGATAAAGCCCTTCCTGAACCAGCTAATGTCCCAGCTCCTCAAAACGAAACCACTATAGCTGAAGAGACTGCTACATACAGGGATATACCTCAGGATAGTCTTATGAATTTCACTGATGAAACTTGTCAACAAAGTGGTGACAACTTCCCAGTACAGTTTCTCAGTATGCCTGAACTTGATCCGGAACCTTCTGAAGAGAAGTCTGGTGTTGAATTGCTGGCTGAATTTAATATAGACAATGACACAGACCAAGGAATTGCAAGGAAAATAGGAGAAGTTAAAGAGATTGATCATAACTCACTGAATTGTGTGCTGCCATCAATCAGCAATGATCATATTGATGATGTGTCTATGTCAATGGCTGAAAAGAACAATGAAAATTCAGATCACTACCATGGTGAATGGGACCAAATGTTCAATGATATTATGATTACCAGAGGCCCCAATCAAGAATGTGGGTCCGATTTGAAAGAATTGTATTCTCAAATCTCTAAAACTATTGATTTGCTTAATtcttaa
Protein Sequence
MLKIGLSNMQDDRNAIFQMRFPQKLWYLLNFRTDAILWGGTGRTILLNYRILHNYLQCDHSIFKTTNISSFVRQLNLYGFRKVTSHLQDPLCNSSNPYMHEYVHDYFQYGKPELLNKITRKALAMKRNFKPKNLYSNVEQLLFLTPLQKARRALRMALKKAAQDLFVQNSPKHFCNLKFECDDSQDDYCEDEENIEFDWLMTNDASTDKALPEPANVPAPQNETTIAEETATYRDIPQDSLMNFTDETCQQSGDNFPVQFLSMPELDPEPSEEKSGVELLAEFNIDNDTDQGIARKIGEVKEIDHNSLNCVLPSISNDHIDDVSMSMAEKNNENSDHYHGEWDQMFNDIMITRGPNQECGSDLKELYSQISKTIDLLNS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00041697; iTF_00042543; iTF_00039707; iTF_00301089; iTF_00302017; iTF_01094818; iTF_01092989; iTF_01093952; iTF_01119234; iTF_01179426; iTF_00120403; iTF_01246741; iTF_01180246; iTF_01361506; iTF_01439811; iTF_01338500; iTF_00040709; iTF_00157125; iTF_01197642; iTF_00706859; iTF_00237381; iTF_00072102; iTF_00172646; iTF_00363942; iTF_01030118; iTF_00071304; iTF_00448936; iTF_01084168; iTF_01085055; iTF_01435977; iTF_00017259; iTF_00043404; iTF_01531884; iTF_01230445; iTF_00147214; iTF_01027216; iTF_00677457; iTF_00677456; iTF_01173202; iTF_01166515; iTF_00404620; iTF_00907796; iTF_00906031; iTF_00794261; iTF_00869543; iTF_01117109; iTF_01487637; iTF_00186058; iTF_00327005; iTF_01342134; iTF_01151991; iTF_01502007; iTF_01491800; iTF_00038617; iTF_00281049; iTF_00282186; iTF_01260025; iTF_00274363; iTF_00177030; iTF_00036540; iTF_00049820; iTF_00171676; iTF_01192540; iTF_01525852; iTF_00636189; iTF_00637413; iTF_00667261; iTF_01025949; iTF_00771794; iTF_01028182; iTF_01538653; iTF_00037694; iTF_00823838; iTF_00441413; iTF_00822828; iTF_01360539; iTF_00908735; iTF_00373832; iTF_00785922; iTF_01424962; iTF_01377387; iTF_00018094; iTF_00783346; iTF_00383541; iTF_00450037; iTF_00784314; iTF_00446025; iTF_01062723; iTF_00685345; iTF_00711745; iTF_00928579; iTF_01063684; iTF_01061803; iTF_01532942; iTF_01534712; iTF_00445030; iTF_00447036; iTF_00375094; iTF_01526936; iTF_00924513; iTF_00622721; iTF_00122278; iTF_00123271; iTF_01075294;
90% Identity
iTF_00172646;
80% Identity
-