Acen021858.1
Basic Information
- Insect
- Atethmia centrago
- Gene Symbol
- HSFX4
- Assembly
- GCA_905333075.2
- Location
- HG995375.1:9156733-9158576[+]
Transcription Factor Domain
- TF Family
- HSF
- Domain
- HSF_DNA-bind domain
- PFAM
- PF00447
- TF Group
- Helix-turn-helix
- Description
- Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 2.7e-23 3.5e-19 71.0 0.0 1 100 13 113 13 113 0.87 2 2 1.1 1.5e+04 -1.6 0.1 40 56 117 133 115 172 0.76
Sequence Information
- Coding Sequence
- ATGCAAGAAGATAAAAATGCAATATTTCAGATGCGTTTTCCTCAAAAATTGTGGTATTTACTGAATTTACGAACAGATGCTATTCTATGGGGTGGTACTGGAAGAACAATTTTGTTGAATTATCGCATCCTCCATAATTATTTGCAATGCGATCACTCAATTTTTAAAACTACAAATATATCAAGCTTTGTAAGACAGCTCAACCTATACGGGTTCAGAAAGGTTACTTCACATTTGCAAGATCCTCTGTGTAATTCTAGTAACCCATACATGCACGAATACGTTCACGACTACTTTCAATACGGTAAACCTGacttactaaataaaataacacgGAAAGCTCTAGCTATGAAAAGAAATTTTAAACCTAAGaaTCTTTACAGCAATGTTGAACAACTGCTGTTCTTGACACCCCTACAAAAGGCACGCCGAGCTCTACACGTGGCCCTGAAAAAAGCTGCTCAGGACTTATTTGTACAAAATTCACCAAAGCAATTTTGTAATCTTAAGTTTGAATGTGAAGATTCACAAGATGACTACTGTGAAGATGAAGAAAATATTGAATTTGATTGGCTGATACCTAATGATCCAGAAAAAGTCCTTCCAGAAACAGCTAATTCCCAAGTTCCTCAGAATGAACCAACAATACCAGAGGACACCGCTTCATACAGAGATACGTCTCAAGATACCTTGATGAATTTTACTGAAGAAGCGTGTCAACAGAATACTGATAACTTCCCAGCCCAGTTTTTGAGCATGCCTGATCTTGACCCAGAACCTCGGGAAGAAAACTCAGGTGTTGAATTATTGGCTGAGTTTAATATTGACAATGACACAGATCAAGGAATAGCAAGGAAGATTGGGGATGGTCAAGAAATTGACCACAATTCTTTGAATTGTGTTCTTCCCTCAATAAGTAATGACCAGATTGATGATGTCTCTATGGCTGAGaaaaataatgaaaattcaGATCATTACCATGGGGAATGGGACCAAATGTTCAATGATATTATGATAAACAGAGGACCTAATCAAGAGTGTGGATCTGATTTGAAAGAACTTTATTCTCAAATATCTAAAACCATAGATTTACTTAactcttaa
- Protein Sequence
- MQEDKNAIFQMRFPQKLWYLLNLRTDAILWGGTGRTILLNYRILHNYLQCDHSIFKTTNISSFVRQLNLYGFRKVTSHLQDPLCNSSNPYMHEYVHDYFQYGKPDLLNKITRKALAMKRNFKPKNLYSNVEQLLFLTPLQKARRALHVALKKAAQDLFVQNSPKQFCNLKFECEDSQDDYCEDEENIEFDWLIPNDPEKVLPETANSQVPQNEPTIPEDTASYRDTSQDTLMNFTEEACQQNTDNFPAQFLSMPDLDPEPREENSGVELLAEFNIDNDTDQGIARKIGDGQEIDHNSLNCVLPSISNDQIDDVSMAEKNNENSDHYHGEWDQMFNDIMINRGPNQECGSDLKELYSQISKTIDLLNS*
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01363018;
- 90% Identity
- iTF_00622721; iTF_01094818; iTF_01119234; iTF_01338500; iTF_00237381; iTF_00123271; iTF_00071304; iTF_00147214; iTF_01027216; iTF_01092989; iTF_01093952; iTF_00373832; iTF_00448936; iTF_01117109; iTF_00375094; iTF_01192540; iTF_00302017; iTF_00785922; iTF_01377387; iTF_00018094; iTF_00783346; iTF_00383541; iTF_00450037; iTF_00784314; iTF_00072102; iTF_01487637; iTF_00186058; iTF_01260025; iTF_00327005; iTF_00171676; iTF_00049820; iTF_01538653; iTF_01439811; iTF_00122278; iTF_00924513; iTF_00177030; iTF_00363942; iTF_00906031; iTF_00907796; iTF_01526936; iTF_01525852; iTF_00037694; iTF_01030118; iTF_01084168; iTF_01085055; iTF_01531884; iTF_01062723; iTF_00685345; iTF_00711745; iTF_00928579; iTF_01063684; iTF_01061803; iTF_01532942; iTF_00120403; iTF_01246741; iTF_01534712; iTF_01230445; iTF_01028182; iTF_01025949; iTF_01342134; iTF_01363018; iTF_00038617; iTF_00036540; iTF_00274363; iTF_00447036; iTF_00301089; iTF_00445030; iTF_00446025; iTF_00667261;
- 80% Identity
- -