Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_947568825.1
Location
OX387615.1:16059634-16077152[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.2 7e+03 -2.6 0.0 31 48 328 345 320 348 0.85
2 2 8.6e-16 2.7e-12 46.7 0.0 5 66 662 722 658 738 0.92

Sequence Information

Coding Sequence
ATGGAAACCACAGACATCTTATTAGAAAATAATGGTCCTGAACCACCAGAGATAGAAGCTGCATTGAACACCTCAGATACCAGCAAGGAGTCTGAAGAAAATTTAGATGCAATAAGAAAATTTATTGAAGATCAAGACAGAGAATTGCAAGAGAAAAATAATAAAGCAAATGTTGCGGAGTCAGTTGAACCTGAAATTTTGAGTAACAATGATGCAAATACAGAAAATAATAAAGGCACTTGTAATGATGTTGTAAATAATAAGAATGAAGGAACTACAACAGAGGTTGCTTCCAGTGTTTTGGATATGATACTAAGTGAATCAGAAGTAAAAATACAGGATAAAAAGGATTTTGCACCCGTGCCCAAGTATAACAGTTTGAGTCCAGCTGATAAAGTTGCTGGTGGCAGTATTTCTCTATCGATTGGCTCAAGAATAGAAGCCAAAGATTTCAGTGATGATTGGCATCCAGCGCAGATTGTGGAGGTTGATTATGACGAGATGGAGGTGTTGGTTCGTTATGAGCCGCACAACAAGAGTATTGCTCGTCACGACGAATGGATTAGCGTAAGCAGCCCTCGTTTAAGACCAACAAATACTAGTACCAACTCTAAATGTGACACAACTGAAGACAAGCTGCCTGAGCAGGTCGTCCAAGTAAAGGAAGAGATTAAAGAAGTAAAGGTGGAAGAAAAAGCGAAGATAACGTTCGCGGTGGGAGAGAGATGTCTGGCGCGATGGAGGGATAATAGGAGATTCGTCGCCACCGTACATAATGATTTGGGAAATGGTACCTATGAAATAATATTTGACGACGGTTTTTACTGGAAATGCAACGTATCAAGACTTTACAAATGGAAGCAAACTGGAAAGAATGATCTTTTGACCGTAGACACATCATTACATTCTGCCACGGGGGCTCCATCGCCCATACAAATCGGAGGTCCAAGCACGGCAGCTACACCAGCCAACCCAACTGGTTTCCACACACATCTTTTTGACCCAACGCGAGACTACCTCAGCTCCAAAAGTGAACGACGCGAAATGAAAAGAAAATTGAACATAAAAGAGATATTTAATATTGGTCAAAAGAAACAAAAAGCCAAATCGGATAAAGTTGTGAAAAAGCCGAGGATAATCAGAAGGCCTCCTAAAGTTAAAAGTGACCCTATTAAAAAAGAACTGAAGGTTGAACTTACAAGGGAGATACCAGATGCTGTTGCTTCTATCATTGGCTCAATGAAAAAAGACGAAATAGAAGAAATAAAAACCGAAGACATTATTGAAGTAAAACTTGAAGAAATAGACAAGGATGATTTAGAAGTCACAGATGCTACAGAATCCGAAAATGATGTACAGGTAGCGGATGATTTTACAGTGGATCCATTTAAAGCAGAATTAGACCCTGTACACGAAGAAGACGTAAAACTTGAAAAATTTGACAAACAAGATGGCAAGCACGAGGAAGTAATCGATAGGATGAAAGAGGTCATCAACAAACTGGAAGGTGGTCTGAAGGAGGACACGTTAAATTCTCCCAAAGTAGATATTAAGGAAGAAACTCCAATATCTACGAAACTTGAAAACATAGACGCAAAAACCGAAGAACCAAGCGAAAACGTAGTCGATGACGGCGTCACAGAGGCTAGCACTGCAAAAAAAGTGAAATCTAAAAAGCTTTCCAAGATTAAAAAAAGTAAGAAACTTAGAATGTTGCAGGAGAAGAAGGTAAAGAAACAAGTGCAAAAAGTCAAGAGTGAACTTGAAGAGATGAAAAAGCAAGTGGAAGAAATGAGAAAGCAGATGTTGTTGAAGACGCAGGAGTTTGCGAAGGTGCAGTCGGAGATGCCGGAGAGTTTCCTGTTACCCGGAGAGTGGTGTTGTCGGTGGCTGAACGGACAGCCAGTGGGGACGGTTAGCGAGATCGTGTGCGAGACTAAAGTTGATGGAGACGGGAAGCCGGGATTGCCGCGGCGAAGTGTTCAGGTGGAAGACAAGCGGTTACCACTAGGATGGACAAAACACATGGTACGCAGAAGCTTGGGACATTCTGCCGGCAAGTGGGACGTCGTACTTGTTAGCCCGGAAAATCGTCGGTTCCACACAAAGACAGACATGCGTAATTACCTCGAGAACAATCCAGACGAGTCCCTGAAGCCGTATGAAGCTGCGCTGATGGACTTTGGGGTGCACTTGAAGTTGGCTCGACGTATGGGATGGATCACCAACACTCCAGGGGGAGTGGCCGACGGGCCCACACTACCCTGCGGGACCTTGCATAGCACCTCACCCTTGGTTAAGAGGAAGAAGCTGAACCTTAAGAAGTCGGAGAAGAAAAGCCGGCGGCAGAAGAAAAATAAACTGAATTTCAGGATGAAGTTGGCTTTGGCATCTCAGAATGTCGTTGACGACACTTGTATGGAAACCACTTCTGACTCTGTGGCGACCCCGGAACCCGTGCTTGATACTATGACCTTAGAAGATGGCTATGTGTATGTTGGCTCCCTCAAAGTTCAAATAATAGAGAATCTCCTCCGATGTCCTGCTGAAGGATGCTTCAAGAATTTCAGAAACAACACATTGTTGCAAATGCACATTAAGCATTATCATCGAGAATTAAGAGAAAAGCTGGGTGACACCCCGAAAGTTCTCGACTTAGCATATGCCAGAACTATGCCACTAGACACTGAGCCGGTAAAGCAAGTGGAGAGCAAGGTTCTAAAGGTCAAGATCTCCAAACCGAAGCGTGAGGAACCTAAACTGGAAGCTACTGAAGATAAACCCGATTTACTCATTGATATAGCACCCAAAACTCCAGTTAGTCAAGACGGTGAAAGTACACCAAAAGCCCAGGATTCACCTAAGTTGCGTGATGCGTTGGTCAACAAGCCGGTGAAAAGACCTAAAGTATTGCTTCCAGTCAGAAGACCAGAGCTTGAACCGGAGCCAACGAATGTGGACGATAATGAAGAGCTACCAGAAATGGTGGTCGATAACTATAGTATGATAGAGCCGTTAGATTTTGAGACGGCGATCTCTACGCATACTGTGACTAAACCTGTGAGTGAAAAACGGAAGAAGGATAAGAACTGCAAATCTCTGACGGTGATGTCGCAAAAGGCAAGCGAGGATGAGGAATGGTTATCGAACTGTGACTTCGAGACGCAGTCCAGTTTCCCGAGGTCTGGCACGCCCGACTCTAAATCGATGGAGTTGCAATTAATTAAGGCGCGGGGTTTAACGCCGGAATCTGCTGACGAGCACAACGACGTTCAGAAATACACGTACACGGAAAACGGCGAGCGCGTGAAGATAGTGCACATGAAGCGCGAGGAGATCATCAACTGCCACTGCGGGTTCCGCGAGGAGGACGGGCTCATGGTGCAGTGCGAGCTGTGTCTGTGCTGGCAGCACGCGCTCTGCCACAACATACAGAGCGAGGCGCAGGTGCCGGAGAAGTACACGTGCAGCATCTGCCTGAACCCCCGGCGCGGGAGGCGGTCGCAGCGGTTCCTGCACGACCAGGACCGGCTGTACGAGGGGCTGCTGCCGGGCGCGCGGCCCTGCGACCTGCTGCGTCGCTCGCATGAGCTCTCCGGCAACCTGCTGCGGATACAAGACGCGCTGCACGCGCTCAGGGTCAAGTGCTTTGTCGCATCCAAAAAAGATCACCCGAAACTATACCTATGGGCAAAAGACTGGGAGCACGCTGAGATATCGTACACTCAAGAGAAGCTCAACTCTGATTACTCGGACTTGAACATTATGATCAACACGGTCGGCAAGGAGAACATGCCGATCAAACCTGAGGATATGAAGGACATGCAGCTCGGACTACCCTCGGACGACGCGGACCTTGATAGGTTCTCGCAGCGAGATAATCAACTGAGCCCGCACGTGTTGCTGACCAACTTGCTGTCGAGTCCTGGCGGTGCGTCACTTGAGCTGCCCATAAGTACATCCGAGTTGGAGACGCTCGCCAAATCCGTACAAGAGCAAGAGTGTGCAGTGGCGGTGGCGGCGGCGGCAGTGGGTCCGCAGCCCGAGGCGGCCATCGAGAACGGCGCGTGTCGCGTGCGCCTGCTGCGCCACCTGCAGCGCTGCCACGCGCTCGTCGACGCGCGGCTCGACTCCATCGAGGCGCAGGTGGCGGAGCTGGAATCTCAAGACCCGTCGTTCGAAGACGACGAGACGCCCGACTTCTTCCCGCGAACAAAACAGACTGTTCAGATGCTGCTGCGGGATCTGGACACTATGGAAGAGTTGGGAATCATCACTTAA
Protein Sequence
METTDILLENNGPEPPEIEAALNTSDTSKESEENLDAIRKFIEDQDRELQEKNNKANVAESVEPEILSNNDANTENNKGTCNDVVNNKNEGTTTEVASSVLDMILSESEVKIQDKKDFAPVPKYNSLSPADKVAGGSISLSIGSRIEAKDFSDDWHPAQIVEVDYDEMEVLVRYEPHNKSIARHDEWISVSSPRLRPTNTSTNSKCDTTEDKLPEQVVQVKEEIKEVKVEEKAKITFAVGERCLARWRDNRRFVATVHNDLGNGTYEIIFDDGFYWKCNVSRLYKWKQTGKNDLLTVDTSLHSATGAPSPIQIGGPSTAATPANPTGFHTHLFDPTRDYLSSKSERREMKRKLNIKEIFNIGQKKQKAKSDKVVKKPRIIRRPPKVKSDPIKKELKVELTREIPDAVASIIGSMKKDEIEEIKTEDIIEVKLEEIDKDDLEVTDATESENDVQVADDFTVDPFKAELDPVHEEDVKLEKFDKQDGKHEEVIDRMKEVINKLEGGLKEDTLNSPKVDIKEETPISTKLENIDAKTEEPSENVVDDGVTEASTAKKVKSKKLSKIKKSKKLRMLQEKKVKKQVQKVKSELEEMKKQVEEMRKQMLLKTQEFAKVQSEMPESFLLPGEWCCRWLNGQPVGTVSEIVCETKVDGDGKPGLPRRSVQVEDKRLPLGWTKHMVRRSLGHSAGKWDVVLVSPENRRFHTKTDMRNYLENNPDESLKPYEAALMDFGVHLKLARRMGWITNTPGGVADGPTLPCGTLHSTSPLVKRKKLNLKKSEKKSRRQKKNKLNFRMKLALASQNVVDDTCMETTSDSVATPEPVLDTMTLEDGYVYVGSLKVQIIENLLRCPAEGCFKNFRNNTLLQMHIKHYHRELREKLGDTPKVLDLAYARTMPLDTEPVKQVESKVLKVKISKPKREEPKLEATEDKPDLLIDIAPKTPVSQDGESTPKAQDSPKLRDALVNKPVKRPKVLLPVRRPELEPEPTNVDDNEELPEMVVDNYSMIEPLDFETAISTHTVTKPVSEKRKKDKNCKSLTVMSQKASEDEEWLSNCDFETQSSFPRSGTPDSKSMELQLIKARGLTPESADEHNDVQKYTYTENGERVKIVHMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQSEAQVPEKYTCSICLNPRRGRRSQRFLHDQDRLYEGLLPGARPCDLLRRSHELSGNLLRIQDALHALRVKCFVASKKDHPKLYLWAKDWEHAEISYTQEKLNSDYSDLNIMINTVGKENMPIKPEDMKDMQLGLPSDDADLDRFSQRDNQLSPHVLLTNLLSSPGGASLELPISTSELETLAKSVQEQECAVAVAAAAVGPQPEAAIENGACRVRLLRHLQRCHALVDARLDSIEAQVAELESQDPSFEDDETPDFFPRTKQTVQMLLRDLDTMEELGIIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00859557;
90% Identity
iTF_00859557; iTF_00859490;
80% Identity
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