Basic Information

Insect: Lapara coniferarum
Gene Symbol: MBD-R2
Assembly: GCA_949316025.1
Location: OX438931.1:17128693-17145317[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.7 1.3e+04 -3.2 0.0 31 48 420 437 417 439 0.85

2 2 6.5e-16 3.1e-12 46.8 0.0 5 66 756 816 752 873 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.7	1.3e+04	-3.2	0.0	31	48	420	437	417	439	0.85
2	2	6.5e-16	3.1e-12	46.8	0.0	5	66	756	816	752	873	0.91

Sequence Information

Coding Sequence: ATGGGTGTAAAGAACTGTTGTGTAGAAACATGTAAATCCTGCTCTACAAGAAAGGAAGACAATGGTGTCACATATCACAGATTTCCAAAAAATCTGGCTTTATATAACACTTGGATGTCAATAACTTGTTGCAAAGACTCAAACTTGGCAAAGTATGTGTGCTCAAGGCATTTCTGTAAACATGACTTTCAATCGTATAAGGACTCTAAGTACATATTGAAGTCAGATGCGGTGCCCTCAATTTTTCCATGGACCATGTCTGAGATATCTGATAAAATGGAAACCACAGACATCTTATTAGAAAATAATGGATGTGAACCACCGGAGATAGAAGCTGCATTGAACACCTCAGATACCAGCAAAGAGTCTGAAGAAAATTTAGATGCAATaagaaaatttattgaagatcAAGACAGAGAATTGtatgagaaaaataataaatcaaatgtTGCACAGTCAGTTGAACTTGAAATTTTGGATAACAATGATGCAAATAAAGAAAGTAATAAAAGCACTTGTAATGATGTTATAAATAACAAGAATGAAGGAACAACGGAGGTTGATTCCAGTGTTATGGATATGATACTAAGTGAATCAGAAGTAAAAATAGAGGATAAAAAGGATTTTGCACCCGTGCCCAAGTATAACAGCTTGAGTCCAGCAGCAGATAAAGTTGCTGGTGGCAGTATTTCTCTATCGGTTGGTTCAAGAATAGAAGCCAAAGATTTTGGCGATGATTGGCATCCAGCGCAGATTGTGGAGGTTGATTATGACGAGATGGAGGTTTTGGTTCGTTATGAGCCTCACAACAAGAGTATTTCTCGTCACGATGAATGGATTAGCGTGAGCAGCCCTCGTTTAAGACCAACATCTACTCGCACCACCGCTAAACTTGACACAGCCGAAGACAAGATGCCTGAGCAGGTCGCTCAAGTAAAGGAAGAGATTAAAGAAGTAAAGGTGGAAGAGAAAGCGAAGTTAACGTTCGCGGTGGGAGAGAGATGTCTGGCGCGGTGGAGAGATAATAGGAGATTTGTGGCCACCGTACATAATGATTTGGGCAATGGTACCtatgaaataatatttgacGACGGTTTTTACTGGAAATGCAACGTATCAAGACTTTACAAATGGAAGGAAACTGGAAAAAATGATCTTTTGACTGTAGACACATCATTACATTCTCCCACGGGGGCTCCATCGCCCATACAAATCGGAGGTCCAAGCACGGTAGCTACACCAGCCATCCCAACTGGTTTCCACACACATCTTTTTGACCCAACGCGAGACTACCTCAGCTCCAAAAGTGAACGACGCgaaatgaaaagaaaattgAACATAAAagagatatttaatattggtcaaaagaaacaaaaaactaAATCGGATAAAGTTGTGAAAAAGCCGAGGATAATCAGACGGCCTCCTAAAGTTAAAAGTGACCCTATTAAAAAAGAACTGAAGGTTGAACTTACAAGGGAGATACCAGATGCTGTTGCTTCTATCATTGGTTCAATGAAAAAAGACGAAATAAAGGTAGAAGAATTAAAAACCGAAGACATTATTGAAGTAAAACTTGAAGAAATAGACAAGGATGATTTTGAAGTCACAGATGCTACCGAATCAGAAAATGATGTACAGGTAGCGGATGATTTTACAGTGGATCCATTTAAAGCAGAATTAGACCCTGTACACGAAGAAGACGTAAAGCTTGAAAAATTTGATAAACAAGATGGCAAGCACGAAGAAGTAATCGATAGGATGAAAGAGGTCATCAACAAACTGGAAGGTGGTCTGAAAGAGGAAACAGTAAATTCTCCCAAAGTAGATATTAAGGAAGAAACTCCAATACCTACGAAACTTGAAAACATAGACGCAAAAACCGAAGAACCAAGCGAAAACGTAGTCGATGACAGCGTCGCAGAGCCTAGCACTGCAAAAAAAGTGAAATCTAAAAAGCTTTCCAAGATTAAGAAAAGTAAGAAACTGAGAATGTTGCAAGAGAAGAAGGTAAAGAAACAAGTGCAAAAAGTCAAGAATGAACTTGAAGAGATGAAAAAGCAAGTGGAAGAAATGAGAAAGCAGATGTTGTTGAAGACGCAGGAGTTTGCGAAGGCGCAGTCAGAGATGCCGGAGAGTTTCCTGTTACCCGGAGAGTGGTGTTGTCGGTGGCTGAACGGACAGCCAGTGGGGACGGTTAGCGAGATCGTGTGCGAGACTAAAGTTGATGGAGACGGGAAGCCCGGATTGCCGCGGCGAAGTGTTCAGgtGGAAGACAAGCGGTTACCACTAGGATGGACAAAACACATGGTACGCAGAAGCTTGGGACATTCTGCCGGCAAGTGGGACGTCGTACTTGTTAGCCCGGAAAATCGTCGTTTCCACACAAAGACAGACATGCGTAATTACCTCGAGAACAATCCAGACGAGTCCCTGAAGCCGTATGAAGCTGCCCTGATGGACTTTGGGGTGCACTTGAAGTTGGCTCGACGTATGGGATGGATCACCAACACTCCGGGCGGTGTGGCCGACGGGCCCACACTACCCTGCGGTACCTTGCATAGCACCTCACCCTTGATTAAGAGAAAGAAGCTGAGCCTTAAGAAATCGGAGAAGAAAAAACGCCGGCAGAAGAAAAACAAACTGACTTTCAGGATGAAGTTGGCTTTGGCATCTCAGAATATCGTTGACGACACTTGTGTGGAGACCACTTCTGACTCCGTGGCGATGCCGGAACCCGTGCTTGACACTATGACCTTAGAAGATGGCTATGTGTACGTCGGCTCCCTAAAAGTCCAAATAATAGAGAATCTCCTCCGATGTCCTGCTGAAGGATGTTTCAAGAATTTCCGAAACAACACATTGTTGCAAATGCACATTAAGCATTATCATCGAGAATTAAGAGAAAAGTTGGGTGACACGCCGAAAGTTCTCGACTTGGCATATGCCAGAACTATGCCACTAGACCCTGAGCCGGTAAAGCAAGTGGAGagcaaggttctaaaggtcaagATCTCTAAACCGAAGCGTGAGGAACCTAAATTGGAAGTACCTGAAGTTAAACCCGATTTGCTTATTGATATAGCACCCAAAACTCCAGGTAGTCAAGATGGTGAGAGTACACCAAAAGCCCAGGATTCACCTAAGTTGCGTGATGCGTTGGTCAACAAGCCGGTGAAAAGACCAAAAGTATTGCTTCCAGTCAGGAGACCAGAGCTTGAACCGGAGCCAACGAATGTGGACGATTATGAAGAGCTGCCAGAAATGGTGGTCGATAACTATAGTATGATAGAGCCGTTAGATTTTGAGACGGCGATCTCTACGCATACTGTGACTAAACCTGTGAGTGAAAAACGGAAGAAGGATAAGAACCGCAAATCTCTGACGGTGATGTCGCAAAAGACGAGCGAGGATGAGGAATGGTTTGCGAACTCTGACTTCGAGACGCAGTCCAGTTTCCCGCGGTCTGGCACACCCGACTCTAAATCGATGGAGTTGCAATTAGTTAAGGCGCGGGGCTTAACGCCGGAATCTACTGACGAGCTTAAGGACTCGCAGAAGTACACGTACACGGAAAACGGCGAGCGCGTGAAGATAGTGCACATGAAGCGCGAGGAGATCATCAACTGCCACTGCGGGTTCCGCGAGGAGGACGGGCTCATGGTGCAGTGCGAGCTGTGCCTGTGTTGGCAGCATGCGCTCTGCCACAATATACAGAGCGAGGCGCAGGTGCCGGAGAAGTACACGTGCAGCATCTGCGTGAACCCCCGGCGCGGGCGGCGGTCGCAGCGGTTCCTGCACGACCAGGACCGGCTGTACGAGGGCGTGCTGCCGGGCGCGCGGCCGTGCGACCTGCTGCGTCGCTCGCACGAGCTGTCCGGCAACCTGCTGCGCATACACGACGCGCTGCACGCGCTCAGGGTCAAGTGCTTTGTCGCATCcaAAAAAGATCACCCGAAACTATACTTATGGGCAAAAGACTGGGAGCACGCTGAGATATCGTACACTCAAGAGAAGCTCAACTCTGATTACTCAGACTTGAACATAATGATCAATACAGTCGGGAAGGAGAACATGCCGATCAAACCCGAGGACATGAAGGACATGCAACTCGGACTACCCTCGGACGACGCGGACCTTGATAGgtTCTCGCAGCGTGACAATCAACTGAGTCCGCATGTGTTGCTGACCAACTTGCTATCTAGTCCTGGCGGCGCGTCGCTTGAGCTGCCTATAAGTACATCCGAGTTGGAGACGCTCGCCAAATCCGTTCAAGAGCAAGAGTGTGCAGTGGCGGGGGTGGCGGGGGTGGCGGCGGAGGGTCCGCAGCCCGAGGCGGCCATCGAGAACGGCGCGTGTCGCGTGCGCCTGCTGCGCCACCTGCAGCGCTGCCACGCGCTCGTCGACGCGCGGCTCGACTCCATCGAGGCGCAGGTGGCGGAGCTGGAATCTCAAGACCCATCGTTCGAAGACGACGAGACGCCCGACTTCTTCCCGCGAACAAAACAGACTGTTCAGATGCTGCTGCGGGATCTGGACACTATGGAAGAGTTAGGAATCATCACttaa
Protein Sequence: MGVKNCCVETCKSCSTRKEDNGVTYHRFPKNLALYNTWMSITCCKDSNLAKYVCSRHFCKHDFQSYKDSKYILKSDAVPSIFPWTMSEISDKMETTDILLENNGCEPPEIEAALNTSDTSKESEENLDAIRKFIEDQDRELYEKNNKSNVAQSVELEILDNNDANKESNKSTCNDVINNKNEGTTEVDSSVMDMILSESEVKIEDKKDFAPVPKYNSLSPAADKVAGGSISLSVGSRIEAKDFGDDWHPAQIVEVDYDEMEVLVRYEPHNKSISRHDEWISVSSPRLRPTSTRTTAKLDTAEDKMPEQVAQVKEEIKEVKVEEKAKLTFAVGERCLARWRDNRRFVATVHNDLGNGTYEIIFDDGFYWKCNVSRLYKWKETGKNDLLTVDTSLHSPTGAPSPIQIGGPSTVATPAIPTGFHTHLFDPTRDYLSSKSERREMKRKLNIKEIFNIGQKKQKTKSDKVVKKPRIIRRPPKVKSDPIKKELKVELTREIPDAVASIIGSMKKDEIKVEELKTEDIIEVKLEEIDKDDFEVTDATESENDVQVADDFTVDPFKAELDPVHEEDVKLEKFDKQDGKHEEVIDRMKEVINKLEGGLKEETVNSPKVDIKEETPIPTKLENIDAKTEEPSENVVDDSVAEPSTAKKVKSKKLSKIKKSKKLRMLQEKKVKKQVQKVKNELEEMKKQVEEMRKQMLLKTQEFAKAQSEMPESFLLPGEWCCRWLNGQPVGTVSEIVCETKVDGDGKPGLPRRSVQVEDKRLPLGWTKHMVRRSLGHSAGKWDVVLVSPENRRFHTKTDMRNYLENNPDESLKPYEAALMDFGVHLKLARRMGWITNTPGGVADGPTLPCGTLHSTSPLIKRKKLSLKKSEKKKRRQKKNKLTFRMKLALASQNIVDDTCVETTSDSVAMPEPVLDTMTLEDGYVYVGSLKVQIIENLLRCPAEGCFKNFRNNTLLQMHIKHYHRELREKLGDTPKVLDLAYARTMPLDPEPVKQVESKVLKVKISKPKREEPKLEVPEVKPDLLIDIAPKTPGSQDGESTPKAQDSPKLRDALVNKPVKRPKVLLPVRRPELEPEPTNVDDYEELPEMVVDNYSMIEPLDFETAISTHTVTKPVSEKRKKDKNRKSLTVMSQKTSEDEEWFANSDFETQSSFPRSGTPDSKSMELQLVKARGLTPESTDELKDSQKYTYTENGERVKIVHMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQSEAQVPEKYTCSICVNPRRGRRSQRFLHDQDRLYEGVLPGARPCDLLRRSHELSGNLLRIHDALHALRVKCFVASKKDHPKLYLWAKDWEHAEISYTQEKLNSDYSDLNIMINTVGKENMPIKPEDMKDMQLGLPSDDADLDRFSQRDNQLSPHVLLTNLLSSPGGASLELPISTSELETLAKSVQEQECAVAGVAGVAAEGPQPEAAIENGACRVRLLRHLQRCHALVDARLDSIEAQVAELESQDPSFEDDETPDFFPRTKQTVQMLLRDLDTMEELGIIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00859557;
90% Identity: iTF_01358891;
80% Identity: iTF_00859557;