Basic Information

Gene Symbol
MBD4
Assembly
GCA_949825025.1
Location
OX463782.1:26731921-26734401[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 8.9e-20 3.1e-16 59.4 0.2 8 72 217 280 212 285 0.93
2 2 2.4 8.5e+03 -2.9 0.0 45 58 741 754 740 770 0.83

Sequence Information

Coding Sequence
ATGGACGACGAAGAAAAGTCTGTCATAAAACTACACACACTTGAAAATGGAGATACTGTATGCTTAGCTTCTAACACAGATATTTCCTCTAAAGATTTTGGAGAAGTAAAGGGGTTTGAGAATGAAAAAGAGGAAGAAAAAGAAGCAGAAAATGAAACTAACTTCTCTTTCTTCATTGATGATGTTCGTATCGATGAAAAGGATACCGAGCCTCTACCCAAGAcaataatactaaatattattgatgaaccAGTAATAAAGTCTACACCTACAGAAGATCCAGCTGTAGAAGAAAAAATGTTGGATAATGCTGCAGCAGATGCAGAAACTAAGAAAACTGATGAGATGGATAATGAAGCAAACACTTTGgttataaaacaagaaaagaaagAGGTAGAACATGATCCAGAAGAGAAACTCGAAGAAATGgatttacaaaaagaaaaaagtgaaCCAGAGGCTGCATTTATTGAGAATGCACAAAGCAAAGACAAGAAAGAAGACAGATCTACTGTAAAACCCAccataaaaatcaaattaggCAGACCCAAGTCTTTCAAGTCACCCCAAGGAGTACctgtaataaagaaaaaaggACGTGGCAAACAAACAAGCTGCGAAGATAATGAAGATTATGAAAGCCTATTTGAAAAACCATTGCCAGATGGCTGGTCGCGTAAAGTAAGCCAACGGAAATCAGGAGCATCTGCAGGAAAATATGATGTGTACATTTTCAGCCCTAGCGGACAAAAATTCCGTTCGCGAAAAGAATTGTCCTCATATTTTGAACAGGTAAATCTGACACATTATGATATAAGTGATTTTCAATTTGGAGTAGCATCACCAAAAGTTCAAAAAggaggtaaaaaaattacaaaagataATGTTATACCGCCTCTGCTGTCCATGGCACCTACATCAATCAAAATTGCCAAACTAGGAAAAATCAAAGGAAAAGCTAAAGCTTCATCCTCTGCCTCAAAACTAGTAATGTCTGACAAACCATCAACTTCTGCAGCAACGTTGCTCAGTAACAAAAAGTATTCTCTGATCAGTAACAGCCTTTTTGGTAAGAAAAACATAAAGAAAGGCGATCCTGCATTTCGAGTCAAGGAGCAAAAATTTCTCCTCCGAGAGAAATCAGAAGTTAAAAAAGAGAACATTGTTGATGGAGAAAAACCTGCCGAAATGGATTCAAAAGCCGAGAAAcacaaaatattgattgaagATGACAATCAGCctaaagtaaagaaaattaagaCAGTCAAAGAAAAGCAACCTGCTAAAGAAGAGGAATCGAAAATCGAAGAACAAAAGACTTTCCACTTTGAAAAGTCATCAGATGTTGACCCCAAGATAAAAAAGTTTGTCCTGGAGACTCAACAGCTTCCTTCCTTTGATGATATATCTGCTGGCGGTGAGAAACAGGTGAAAAAACAGAAGACCCTCTTTGAGAAGACGTTGTCTGAGATTGAATTACAAGCAATAAAACCAAAGATAAATAAGTCTGCCAAGGCATCATCTTCTAAAATAATAGTTCCTGCATCAAACAAGATTTCCACGTCAAACTTTGGCATCAAGTCTAAGAAACAAGGTTTTGGTCAACTCTTAAAACCTTCTTCTAAAAAATTGGGACTGGTGATGACAAAGTTCAAGCCATTTTGTCCTCCAAACAGACCTCTCATGAAATCTCCAACTGCTCAATTTACACCTAAAAATGAAAAGGCCACACATGCATCTCGCAGTACTGAACAAGGAGAAGTGGAAAGTACAAATGATAAAACTGTCATAAAGCGAGGCAGAGGACGTCCTCGTAAAGATGAGATGgatgaattaaataaatctcAGCTTAATGCAACTGATGAAAAAGAACTGATAAAAGATATTtctaacaaaaaattgtcagtAACGTTAATCAAGTGTGATGCTGAAGCTGTATCAACAAATGGAAATCTCGTGAATGGTGACAGTGTAACTTACGGTGacacttataaaattaaaaagactaAACTTGTGCCATTAGTCCGTGGTGCTCAAGAAAAATCCATGTGGATCCCTCCAACATCACCTTACAATCTTGTCTATGAAAAACTGTATGAATCACCTTGGAAACTTCTAACTGCAACAATCATTATGAGAAAATCTATAGCCAGAGTAGGAACAACTTTGGTATGGAAATTTTTTGAAGTTTATCCTACTGTGAATACTGTACAAAATGCATCTGAATCTGAACTTGCAACATTCCTTAGAGCCACGACTGAACCTGAAAAATGTGCCCATAAAATCAAGGGATTAGCAAGTGACTTGGAGACTAAAGCCTGGATCTACCCAACTGAATTATCTGGTATTGGCAAGTATGGATCTGATGCTTACAGGATGTTCTGTTTGAACGAATGGCGTGAAGTGCGTCCAGACGATGACTTCGACCTTACCATGTACCACAACTGGCTTTGTCAGAATGCTAAAGCTCTCGGAGTGTAA
Protein Sequence
MDDEEKSVIKLHTLENGDTVCLASNTDISSKDFGEVKGFENEKEEEKEAENETNFSFFIDDVRIDEKDTEPLPKTIILNIIDEPVIKSTPTEDPAVEEKMLDNAAADAETKKTDEMDNEANTLVIKQEKKEVEHDPEEKLEEMDLQKEKSEPEAAFIENAQSKDKKEDRSTVKPTIKIKLGRPKSFKSPQGVPVIKKKGRGKQTSCEDNEDYESLFEKPLPDGWSRKVSQRKSGASAGKYDVYIFSPSGQKFRSRKELSSYFEQVNLTHYDISDFQFGVASPKVQKGGKKITKDNVIPPLLSMAPTSIKIAKLGKIKGKAKASSSASKLVMSDKPSTSAATLLSNKKYSLISNSLFGKKNIKKGDPAFRVKEQKFLLREKSEVKKENIVDGEKPAEMDSKAEKHKILIEDDNQPKVKKIKTVKEKQPAKEEESKIEEQKTFHFEKSSDVDPKIKKFVLETQQLPSFDDISAGGEKQVKKQKTLFEKTLSEIELQAIKPKINKSAKASSSKIIVPASNKISTSNFGIKSKKQGFGQLLKPSSKKLGLVMTKFKPFCPPNRPLMKSPTAQFTPKNEKATHASRSTEQGEVESTNDKTVIKRGRGRPRKDEMDELNKSQLNATDEKELIKDISNKKLSVTLIKCDAEAVSTNGNLVNGDSVTYGDTYKIKKTKLVPLVRGAQEKSMWIPPTSPYNLVYEKLYESPWKLLTATIIMRKSIARVGTTLVWKFFEVYPTVNTVQNASESELATFLRATTEPEKCAHKIKGLASDLETKAWIYPTELSGIGKYGSDAYRMFCLNEWREVRPDDDFDLTMYHNWLCQNAKALGV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01348020;
90% Identity
-
80% Identity
-