Basic Information

Gene Symbol
MBD4
Assembly
GCA_949825025.1
Location
OX463788.1:4213504-4215645[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.5e-20 5.2e-17 61.9 0.2 8 72 106 169 101 174 0.93
2 2 2.5 8.8e+03 -3.0 0.0 45 58 628 641 627 647 0.81

Sequence Information

Coding Sequence
ATGGACGACGAAGAAAAGTCTGTCATAAAACTACACACACTTGAAAATGGAGATACTGTATGCTTAGCTTCTAACACAGATATTTCCTCTAAAGATTTTGGAGAAGTAAAGGGGTTTGAGAATGAAAAAGAGGAAGAAAAAGAAGCAGAAACTGAAACTAACTCCTCTTTCTTCATTGATGATGTACCCACCAGAAAAATCAAATTAGGCAGACCCAAGTCTTTCAAGTCACCTCAAGGAGTACctgcaataaagaaaaaagGACGTGGCAAACAAACAAGCTGCGAAGATAATGAAGATTATGAAAGCCTATTTGAAAAACCACTGCCAGATGGCTGGTCGCGTAAAGTAAGCCAACGGAAATCAGGAACATCTGCAGGAAAATATGATGTGTACATTTTCAGCCCTAGCGGACAAAAATTCCGTTCGCGAAAAGAATTGTCCTCATATTTTGAACAGGGAAATCTGACACATTATGATATAAGTGATTTTCAATTTGGAGTAGCATCACCAAAAGTTCAAAAAggaggtaaaaaaattacaaaagataATGTTATACCGCCTCTGCTGTCCATGGCACCTACATCAATCAAAATTGCCAAACTAGGAAAAATCAAAGGAAAAGCTAAAGCTTCATCCTCTGCCTCAAAACTAGTAATGTCTGACAAACCATCAACTTCTGCAGCAACGTTGCTCAGTAACAAAAAGTATACTCTGATCACTAACAGCCTTtttggtaagaaaaatataaagaaaggtGATCCTGCAGTTCGAGTCAAGGAGCAAAAATCTTTCCTCCGAGAGAAATCGGAAGTTAAAAAAGAGAACATTGTTGATGAAGAAAAACCTGCCGAAATGGATTCAAAAGCCAAGAAACACAAGATGGTGATTGAAGATGACAGTCAGCCTAAAGTAAAGAAAATGAAGACAGTCAAAGAAAAGCAACCTGCTAAAGAAGAGGAATCAAAAATCGAAGAACAAAAGACTTTCCACTCTGAAAAGCCATCAGATGTTGACCCCAAGATAAAAAAGTTTGTCCTGGAGACTCAACAGCTTCCTTCCTTTGATGAAATATCTGCTGGCGGTGAGAAACAGGTGAAAAAACAGAAGACCCTCTTTGAGAAGACGTTGTCTGAGATTGAATTACAAGCAATAAAACCAAAGATAGATAAGTCTGCCAAGGCATCATCTTCTAAAATAATAGTTCCTGCATCAAACAAGATTTCCACGTCAAACGTTGGCATCAAGTCTAAGAAACAAGGTTTTGGTCAACTCTTAAAACCTTCTTCTAAAAAATTTGGACTGGTGATGACAAAGTTCAAGCCATTTTGTCCTCCAAACAGCCCTCTCATGAAATCTCCAACTTCTCAATTCACACCTAAAAATGAAAAGGCCACACATGCATCTCGCAGTACTGAACAAGGAGAAGTGGAAAGTACAAATGATAAAACTGTCATAAAGCGAGGCAGAGGACGTCCTCGTAAAGATAAGATGgatgaattaaataaatctcAGCTTAATGCAACTGATGAAAAAGAACTGATAAAAGATATTtctaacaaaaaattgtcagtGACGTTAATCAGGTGTGCTGCTGAAGCTGTATCAACAAATGGAAATCTCGTGAATGGTGACAGTGTAACTTACGGTGACAAAGTTAAAAAGACTAAACTTGTGCCATTAGTCCGTGGTGCTCAAGAAAAATCCATGTGGATCCCTCCAACATCACCTTACAATCTTGTCTATGAAAAACTGTATGAATCACCTTGGAAACTTCTAACTGCAACAATCATTATGAAAAACTCAACAGCCAGAGTAGGAACAACTTTGGTATGGAAATTTTTTGAAGTTTATCTTACTGTGAAAACTGTACAAAATGCATCTGAATCTGAACTTGCAACATTCCTTAGAGCCACGACTGAACCTGAAAAATGTGCCCGTAAAATCAAGGGATTAGCAAGTGACTTGGAGACTAAAGCCTGGATCTACCCAACTGAATTATCTGGTATTGGCAAGTATGGATGTGATGCCTACAGAATTTTCTGTTTGAACGAATGGCGTGAAGTGCGTCCAGACAATGACTTTGACCTTACCATGTACCACAACTGGCTTCGTCAGAATGCTAAAGCTCTCGGAGTGTAA
Protein Sequence
MDDEEKSVIKLHTLENGDTVCLASNTDISSKDFGEVKGFENEKEEEKEAETETNSSFFIDDVPTRKIKLGRPKSFKSPQGVPAIKKKGRGKQTSCEDNEDYESLFEKPLPDGWSRKVSQRKSGTSAGKYDVYIFSPSGQKFRSRKELSSYFEQGNLTHYDISDFQFGVASPKVQKGGKKITKDNVIPPLLSMAPTSIKIAKLGKIKGKAKASSSASKLVMSDKPSTSAATLLSNKKYTLITNSLFGKKNIKKGDPAVRVKEQKSFLREKSEVKKENIVDEEKPAEMDSKAKKHKMVIEDDSQPKVKKMKTVKEKQPAKEEESKIEEQKTFHSEKPSDVDPKIKKFVLETQQLPSFDEISAGGEKQVKKQKTLFEKTLSEIELQAIKPKIDKSAKASSSKIIVPASNKISTSNVGIKSKKQGFGQLLKPSSKKFGLVMTKFKPFCPPNSPLMKSPTSQFTPKNEKATHASRSTEQGEVESTNDKTVIKRGRGRPRKDKMDELNKSQLNATDEKELIKDISNKKLSVTLIRCAAEAVSTNGNLVNGDSVTYGDKVKKTKLVPLVRGAQEKSMWIPPTSPYNLVYEKLYESPWKLLTATIIMKNSTARVGTTLVWKFFEVYLTVKTVQNASESELATFLRATTEPEKCARKIKGLASDLETKAWIYPTELSGIGKYGCDAYRIFCLNEWREVRPDNDFDLTMYHNWLRQNAKALGV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01348019; iTF_01348021;
90% Identity
iTF_01348019;
80% Identity
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