Basic Information

Gene Symbol
RHOBTB1
Assembly
GCA_949319165.1
Location
OX439237.1:15339631-15347111[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 8.8e-08 2.6e-05 24.6 0.0 7 44 260 296 256 314 0.85
2 3 0.00026 0.077 13.4 0.1 47 104 389 453 375 459 0.77
3 3 5.9e-18 1.8e-15 57.3 0.0 5 107 482 583 479 586 0.93

Sequence Information

Coding Sequence
ATGGATAATGAACAGCCGCACCAGGAGCTCGTCAAGTGCGTGGTGGTTGGTGACACGGCCGTCGGTAAGACGCGGCTCATCTGCGCGCGAGCTTGCAACAAGCAGGTCTCCCTCAGCCAGCTGCTCACAACTCACGTGCCTACAGTGTGGGCCATCGACCAATACCGCATCTACAAAGATGTACTCGAGAGGTCATGGGAGATTGTGGACGGCGTCAACGTGTCGCTTCGTCTGTGGGACACATTCGGCGACCACGAGAAGGACCGGCGCTTCGCGTACGGTCGCTCGGACGTGGTGCTGTTGTGTTTCTCCATCAACAACCCGGCGTCTCTCCGCCACTGTAGGTTGATGTGGTATCAGGAGATACGCCGTTTCTGTCCCCAGACACCAGTTTTACTTGTTGGCTGTAAAAATGATCTCCGCTATATGTATCGAGATGAAACGTACCTAAGTTATTTTCGGGATCGTAGTCCATTTGTTCGAGCAACAAGAAAGAGTGATTTGGTTATGCCAGATGAAGCCAGAAGCGTTGCGCGTGAACTGGGCGTTTACTATTACGAAACGTCGGTGTTCACGTACTACGGAGTTAATGAAGTGTTCGAGAACGCTATCCGTGCTGCGCTCATCGCGCGCAGGCAACAGCGCTTCTGGATGACCAATTTGAAAAGAGTACAACGTCCATTACTTCAGGCACCATTTAAACCACCTATGCCCTTACCACCAGAGGTAGTAGTTTCGCCAAGTTTATATCAAGAAAACATGGCATTCTTATGGCTCAATCAAATACACACCGATTTGGTGGTAGTGGCTGGTTCAGTAGGATTTCCAGTACATCGCTTTATTCTAGCAGCTAGTTCTAATGCCTTTCATCGCTTGCTTACTATGGATATATCTACTGATATCGGTGTCAGAAGTAACAGCGAGTCCAGCATGGTCAGTTCTCTCGGAGAGGCAACTGTAGGAGAATTTAATGATGATactgaatatttaattaataatgatcAAAAATCACCTAAaaaatgggAACAGTTAAAACGAAAATCAAGTGGAAACACATTATCTACAGGTGAAGAAGTAAAGAAACCAACTGTAGTTAGCAGAGAGTTAAATCATCCAGCATTTGAGACCATACAAGTCACAATGAACGATGGCTTACAAACTGGAAATACGCAAACTGTCATAACTCTTACAAAACTTATAACGCCGCAGGCGATGCACCAGTGTCTTAAATTCATCTACACTGGGAATGTAGATAAACGATTTGTTGAACTACAGTCAGCAATGATCGGATTGCTTTTGGAACTACGCCAAGCAGCAGAATTTCTGGAACTTCCTCAGCTTACTGTACTGTTATCAAACATACAAGCAAACCAGCAGTTTCTCAACAGTGATGCAATGGACCATTTCTCCCAGGCATTCCGACAGAGACTGGAGAGTCTGTGTCTGGAGCAGGGTTTGTTTGCAGATGTCGTATTCGAGCTGGACGATGGTGCATATCCTGCGCATAAGCCGATGTTGGCAGCTCGCTGTGATGTCATGAGAGCCATGTTTAGTGGTGACTTTAGAGAAAGTCAAGCCAAAGTTaTTGTGTTCCCGGGAGTGAGAGAATATACATTCCATAAGTTGCTGTGTTATTTATATACGGATGAAATACCAGCGATTGCAGCGGCACGCTGTTTCAACTTATTGGAGTTGGCAAATAGGCTGTGTTTACCAAGGCTTGTGAATTTGGTTGAGTATAGGGTAATTGAAGATTTAGACAGACTATCACAAAGTGATACGAATGAAGCTATCGAACATTGTTTACGATTATTAGAACCGGTGAAGttacaTAATGCACATCAGTTAGCAGATTGGTGTATGAATCATCTTTGTATAAATTACAATAAGTTGTGTAAAATGTCACCAAGAAGCGTTAAATTACTTCATCCGGAAAATCAAGAATACTTAAATGAACATCGGTGGCCACCAGTTTGgTATCTCAAGGATTATGATTACTATCAAAAATGCATTGCAGAACGAGATAAAGAAATAAAACCAAACTTGAAAAGAAATCAAAATAACTCCGGTTGCCTCTGTTTTTCGGGAAAGTCTCGGAAAGCTTTACCGAATGGATCAAACCCAGACGTGGCTACAAGTTTGTTTAGCGAACCAGCAATAAATAATCAAGAAGATAATCTCTGA
Protein Sequence
MDNEQPHQELVKCVVVGDTAVGKTRLICARACNKQVSLSQLLTTHVPTVWAIDQYRIYKDVLERSWEIVDGVNVSLRLWDTFGDHEKDRRFAYGRSDVVLLCFSINNPASLRHCRLMWYQEIRRFCPQTPVLLVGCKNDLRYMYRDETYLSYFRDRSPFVRATRKSDLVMPDEARSVARELGVYYYETSVFTYYGVNEVFENAIRAALIARRQQRFWMTNLKRVQRPLLQAPFKPPMPLPPEVVVSPSLYQENMAFLWLNQIHTDLVVVAGSVGFPVHRFILAASSNAFHRLLTMDISTDIGVRSNSESSMVSSLGEATVGEFNDDTEYLINNDQKSPKKWEQLKRKSSGNTLSTGEEVKKPTVVSRELNHPAFETIQVTMNDGLQTGNTQTVITLTKLITPQAMHQCLKFIYTGNVDKRFVELQSAMIGLLLELRQAAEFLELPQLTVLLSNIQANQQFLNSDAMDHFSQAFRQRLESLCLEQGLFADVVFELDDGAYPAHKPMLAARCDVMRAMFSGDFRESQAKVIVFPGVREYTFHKLLCYLYTDEIPAIAAARCFNLLELANRLCLPRLVNLVEYRVIEDLDRLSQSDTNEAIEHCLRLLEPVKLHNAHQLADWCMNHLCINYNKLCKMSPRSVKLLHPENQEYLNEHRWPPVWYLKDYDYYQKCIAERDKEIKPNLKRNQNNSGCLCFSGKSRKALPNGSNPDVATSLFSEPAINNQEDNL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01229830;
90% Identity
iTF_01343182;
80% Identity
-