Snon013000.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Sesamia nonagrioides
Gene Symbol
pax2-a
Assembly
GCA_017933935.1
Location
JADWQK010000672.1:143483-192214[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.1e-73 2.8e-70 235.7 0.4 1 125 11 135 11 135 0.99

Sequence Information

Coding Sequence
ATGATCCCCTCAGAAACCATACCGATCGATGGTCACGGCGGAGTAAACCAACTAGGCGGAGTATTTGTAAACGGGCGACCACTTCCAGACGTGGTGCGACAGAGAATAGTCGAGCTGGCGCACTCCGGAGTGAGACCGTGCGACATCAGCCGACAGCTGCGGGTGTCGCACGGCTGTGTCTCCAAGATACTGTCGAGGTACTACGAGACAGGCAGCTTCAAGGCCGGTGTGATCGGTGGCTCCAAGCCAAAGGTCGCCACCCCCCCGGTTGTGGACGCCATAGCGGCGTATAAGAGAGAGAACCCAACGATGTTCGCGTGGGAGATCCGGGATAGACTTCTGAGTGAAGGGATCTGCAGCCAGGATAACGTGCCTTCCGTGTCCAGTATAAATAGGATTGTTCGCAACAAAGCCGCAGAGAAGGCGAAACACGCGCATAATCAACAACAACAGCAGCAACAagaacaggagatcagctcaGCGCAGGGAAGCGTTGTATCTGTGATAACCCACGCAGGAAATGCGCCCGGCACGACAGCAGTCCTGTCCCCAACGACAGACCAGCACGTCACCAACACCGGCAGCTACAGCATCAATGGGATCCTCGGCATTGAACAGGTGGAGGGTCTACATAATGGGAACGCGACGGGGTTGAAGAGAAAGAGGCATGAAGACCAGGaTGAAAACCGAGACTTCAACAGCCATTCAGAAGACGACGTCAAGAGACAAAGAAGTCATTATAATGGCGACCAAATATACTCTAACCTCTGGTCATCCTCAAAATGGAGTCTAAAAGACGAATACAAGTTACTATCAGAGCTTGGCGGGGCTGCCGGGGGCGCTACGGGCTACTATGGCGAACTGTTCGACACCCCTTACGAGCATGCAGCCCACCCTCATTACACCCCACATTCAGCAACGAATGACTCAACGGGTTCGAATGGAGGAGCGGGAGGTGAGCCTCCGTCGGCAGCTGCGAGTCCTGATGCGGCGGCGCTGGTGGTGTTACAGCCGCCTGCACCACCATACCCTCCATATGCACATTACGATGGTACGACAACTTTAGCCAGTGAATACGCGTACGCGGCTCCCTACTCACAATACTCGCCGTACGGAGGACCCTACTCGCATTCCGCCGCCACCGGCCTACTGTCCAAGTGGTAA
Protein Sequence
MIPSETIPIDGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHSGVRPCDISRQLRVSHGCVSKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIAAYKRENPTMFAWEIRDRLLSEGICSQDNVPSVSSINRIVRNKAAEKAKHAHNQQQQQQQEQEISSAQGSVVSVITHAGNAPGTTAVLSPTTDQHVTNTGSYSINGILGIEQVEGLHNGNATGLKRKRHEDQDENRDFNSHSEDDVKRQRSHYNGDQIYSNLWSSSKWSLKDEYKLLSELGGAAGGATGYYGELFDTPYEHAAHPHYTPHSATNDSTGSNGGAGGEPPSAAASPDAAALVVLQPPAPPYPPYAHYDGTTTLASEYAYAAPYSQYSPYGGPYSHSAATGLLSKW*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00147425; iTF_01491905; iTF_00960898; iTF_01119298; iTF_00383619; iTF_00447107; iTF_00408420; iTF_00667428; iTF_00822981; iTF_01360580; iTF_01502054; iTF_00049864; iTF_00172883; iTF_01093061; iTF_01094885; iTF_01260069; iTF_01359717; iTF_00077446; iTF_01026150; iTF_01377446; iTF_01534790; iTF_01342183; iTF_01387559; iTF_01388438; iTF_00820040; iTF_00428080; iTF_00859419; iTF_01073577; iTF_01221513; iTF_01062762; iTF_01064632; iTF_00113291; iTF_00858507; iTF_01547521; iTF_00706929; iTF_00404882; iTF_01441014; iTF_00745657; iTF_00795675; iTF_00888235; iTF_00038732; iTF_00621964; iTF_00932492; iTF_00036653; iTF_00122356; iTF_01094004; iTF_01531982; iTF_00007055; iTF_00449071; iTF_00908816; iTF_01564624; iTF_01246865; iTF_00761651; iTF_00275231; iTF_00994323; iTF_01264588; iTF_01487667; iTF_01363077; iTF_00784358; iTF_01118280; iTF_01230540; iTF_00075476; iTF_00406708; iTF_00636372; iTF_00758133; iTF_00790229; iTF_01436053; iTF_01533013; iTF_00637623; iTF_01281303; iTF_01503853; iTF_01502936; iTF_01443799; iTF_00177080; iTF_01153944; iTF_01157701; iTF_01155148; iTF_01158926; iTF_01156412; iTF_01145236; iTF_01538712; iTF_00821785; iTF_00819130; iTF_00823866; iTF_00832890; iTF_00195131; iTF_00121404; iTF_00120477; iTF_01179453; iTF_01180272; iTF_01197694; iTF_01251710; iTF_01525982; iTF_00851775; iTF_00007983; iTF_01028255; iTF_00063552; iTF_01338720;
90% Identity
iTF_00147425; iTF_01491905; iTF_00960898; iTF_01119298; iTF_00383619; iTF_00667428; iTF_01093061; iTF_01094885; iTF_01260069; iTF_01425029; iTF_00077446; iTF_01166662; iTF_01377446; iTF_01534790; iTF_01342183; iTF_01387559; iTF_00049864; iTF_00820040; iTF_00428080; iTF_00819130; iTF_01073577; iTF_01221513; iTF_01062762; iTF_01317258; iTF_01312190; iTF_00858507; iTF_00888235; iTF_00038732; iTF_00621964; iTF_00208846; iTF_01531982; iTF_00007055; iTF_00112465; iTF_01246865; iTF_01029234; iTF_00172883; iTF_00411411; iTF_01487667; iTF_00784358; iTF_01363077; iTF_01118280; iTF_01230540; iTF_00122356; iTF_00036653; iTF_00449071; iTF_00406708; iTF_01094004; iTF_01436053; iTF_01281303; iTF_01443799; iTF_00177080; iTF_01502936; iTF_01538712; iTF_00821785; iTF_00832890; iTF_00195131; iTF_00859419; iTF_00121404; iTF_01179453; iTF_01180272; iTF_00809086; iTF_01251710; iTF_01525982; iTF_00851775; iTF_01028255; iTF_00063552; iTF_01338720;
80% Identity
iTF_01094885;