Basic Information

Insect: Oligia strigilis
Gene Symbol: pax2-a
Assembly: GCA_951800025.1
Location: OX637565.1:12884634-12920499[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 6.6e-74 1.8e-70 235.7 0.4 1 125 10 134 10 134 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	6.6e-74	1.8e-70	235.7	0.4	1	125	10	134	10	134	0.99

Sequence Information

Coding Sequence: ATGTATGAGGAGTACTGGATATTTGACGGTCACGGCGGAGTAAACCAACTAGGCGGAGTATTTGTAAACGGGCGACCACTTCCAGACGTGGTGCGACAAAGAATAGTCGAGCTGGCGCACTCCGGAGTGAGACCGTGCGACATCAGCCGACAGCTGCGGGTGTCGCACGGCTGCGTCTCCAAGATACTGTCGAGGTACTATGAGACAGGCAGCTTCAAGGCTGGCGTGATCGGCGGCTCCAAGCCGAAGGTCGCCACGCCCCCGGTGGTGGACGCCATCGCGGCATACAAAAGAGAGAACCCGACCATGTTCGCGTGGGAGATCCGGGACAGACTCCTTAGCGAGGGGATCTGCAGCCAGGATAACGTGCCTTCCGTGTCCAGTATTAATAGGATCGTTCGCAACAAAGCCGCAGAGAAGGCGAAACACGCgcacaatcaacaacaacaacagcaacaggaACAAGAGATCAGCTCAGCGCAGGGGAGCGTTGTATCTGTAATAACCCACGCAGGCAACGCGCCCGGCACGACAGCGGTGCTGTCCCCGACTACAGACCAGCACGTCACCAACACCGGCAGCTACAGCATCAACGGGATCCTCGGCATTGAGCAGGTGGAGGGACTGCATAACGGGAACGCGACAGGGTTGAAGAGAAAGAGGCATGAAGACCAGGaTGAAAACCGGGACTTCAACAGCCATTCGGAAGACGACGTGAAGAGACAAAGAAGTCATTATAATGGCGACCAAATATACTCTAACCTCTGGTCATCCTCAAAATGGAGTCTAAAAGACGAATACAAGCTACTATCAGAGCTCGGCGGCGCCGCCGGGGGCGCTACGGGGTACTACGGAGAGCTATTCGACACGCCTTATGAGCATGCGGCACATCCACATTATACACCACATTCAGCAACGAATGACTCAACGGGTTCGAATGGTGGAGCGGGAGGTGAGCCTCCGTCGGCTGCTGCGAGTCCTGATGCAGCAGCGCTGGTGGTGTTACAGCCACCTGCACCGCCGTACCCTCCGTATGCACATTATGATGGTACGACAACGTTAGCCAGTGAATACGCGTACGCGGCCCCCTACTCACAATACTCGCCGTACGGAGGACCCTACTCACATTCCGCCGCCACCGGCCTACTGTCCAAGtggtaa
Protein Sequence: MYEEYWIFDGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHSGVRPCDISRQLRVSHGCVSKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIAAYKRENPTMFAWEIRDRLLSEGICSQDNVPSVSSINRIVRNKAAEKAKHAHNQQQQQQQEQEISSAQGSVVSVITHAGNAPGTTAVLSPTTDQHVTNTGSYSINGILGIEQVEGLHNGNATGLKRKRHEDQDENRDFNSHSEDDVKRQRSHYNGDQIYSNLWSSSKWSLKDEYKLLSELGGAAGGATGYYGELFDTPYEHAAHPHYTPHSATNDSTGSNGGAGGEPPSAAASPDAAALVVLQPPAPPYPPYAHYDGTTTLASEYAYAAPYSQYSPYGGPYSHSAATGLLSKW

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01340065;
90% Identity: iTF_01340065;
80% Identity: iTF_00147425; iTF_01340065; iTF_00667428; iTF_01093061; iTF_00038732; iTF_00036653; iTF_00449071; iTF_01246865; iTF_00122356; iTF_01094004; iTF_00121404; iTF_01338720;