Basic Information

Gene Symbol
-
Assembly
GCA_949820665.1
Location
OX463297.1:22321240-22333196[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 28 0.00017 0.018 16.7 4.7 1 23 197 219 197 219 0.98
2 28 0.0011 0.12 14.1 2.0 2 22 250 270 249 270 0.93
3 28 0.00011 0.012 17.3 1.2 2 23 309 331 308 331 0.95
4 28 0.053 5.7 8.8 2.9 2 23 382 404 381 404 0.96
5 28 0.0025 0.27 13.0 0.1 1 23 417 439 417 439 0.97
6 28 4.5e-05 0.0048 18.5 1.0 1 21 479 499 479 500 0.95
7 28 0.00068 0.074 14.8 1.9 2 23 545 567 544 567 0.97
8 28 0.00019 0.02 16.5 1.0 1 23 617 640 617 640 0.97
9 28 8.3e-05 0.009 17.6 1.9 1 23 697 719 697 719 0.97
10 28 0.18 20 7.1 0.2 2 21 731 750 730 754 0.90
11 28 0.0025 0.27 13.0 1.1 1 23 766 790 766 790 0.96
12 28 0.0019 0.2 13.4 5.5 2 23 806 827 805 827 0.97
13 28 0.013 1.4 10.8 2.6 2 23 839 860 838 860 0.96
14 28 0.0065 0.71 11.7 0.6 1 23 870 892 870 892 0.98
15 28 0.048 5.2 9.0 4.5 1 23 918 940 918 940 0.97
16 28 0.00037 0.04 15.6 1.6 1 23 951 973 951 973 0.97
17 28 4e-05 0.0043 18.7 0.5 1 23 981 1003 981 1003 0.97
18 28 0.0077 0.84 11.5 0.3 2 23 1023 1045 1022 1045 0.97
19 28 0.22 24 6.8 3.4 1 23 1063 1085 1063 1085 0.96
20 28 0.025 2.7 9.8 3.3 2 23 1126 1148 1125 1148 0.94
21 28 0.0045 0.49 12.2 0.3 1 23 1169 1191 1169 1191 0.97
22 28 3.6 4e+02 3.0 2.6 2 23 1234 1256 1233 1256 0.84
23 28 0.2 21 7.0 2.0 3 23 1273 1293 1271 1293 0.93
24 28 0.096 10 8.0 2.3 5 23 1303 1321 1300 1321 0.94
25 28 0.0012 0.13 14.0 0.9 1 23 1331 1354 1331 1354 0.96
26 28 2.4 2.6e+02 3.6 2.5 2 23 1371 1389 1371 1389 0.89
27 28 0.23 25 6.8 0.8 2 23 1462 1483 1461 1483 0.94
28 28 0.0028 0.3 12.8 0.5 2 23 1494 1516 1493 1516 0.97

Sequence Information

Coding Sequence
ATGGCCCTCAAGTTGGGAAAATGCAGGCTTTGCCTGAAGCTCGGAGACTTTTACTCCATCTTTACGATGGACAACGCCCTTCAGCTCTCCGACATGGCTATGGACTGCGCCCGAATCAAAATATACGAAGGCGACGGGCTGCCCGACAAGATCTGCTCGGAGTGCGTCCAAAAGCTCAGCAGCGCGTACATCTTCAAGCAGCAATGCGAGCGATCCGACACCGAGCTAAGGCGCAATTACGTGCCTCCACCAGGGTTCAGCGTCACCCCACCACCGCCAAACCGACAAAGCAGCGATTCGGCCTTTTCATCCGCTAATACCGACATGTCTTACCACAAAACCCCTTCCACGGAAAAAGTAACACCAGCGAATCGCGCGCGTAAGAGAAGCCGAGAGAGCGTTGATGAATCTGTGAGCAGTCGATTCCATGACTATAGACCTAGTACTTCAAAACGAGTTGAGGAACTAAGGACTAGTAACAAAAAACCACGAAACCTTTCCCCGAATGCCTCCCTAGATTCTGACTACGAAGACACCAGCTACTTCCCCTACTCTGCCGGAACAGACTCTGACGAACCTTTGCTCTCACACAAATGCAAACAGTGTAGCAAGGAGTTTAAAAGCTCGCTCAGTCTGCGATCGCACATGAAAGttcacaaagaaaaaaaaagcttagGCACTGACAATGCTGTCGTCAACATTCCGAGAAAAAGTCTGGAAGACGCGAAAGATTCTGAAGACAAATTGTCCTGTGACAAATGCCACAAAACGTTCAAGTTGAAAATAATGCTGAAACGACACCAAGAGACTTGCGGAAAGACACCACAACTATCCAAGGAATTGATAATTTCTTTAGAGCCCGTTGACGCGGTTTTAACATCTAAGCAAGAATACTCTAAACCAGTTGACCCTAGCAAGATAGTCAAATGCGAGATGTGCGACACCAAGTTCAAAACTTATGAAAACATGGAGAAGCATATGAAATTTGCGCACGCTGCTGTTCCTAAAACACCAAAACCTGTTCAAGCTAAAGTAGAAAAGATCAACTTCCCTTGCCTATACTGCTGCGTTCCTTTCGACGAATACGCAGCGATGGCTACGCACTTCCACGATTGTCCTAAGCGAGACGATACGCTGCCGCTGAAATGCCCGGTTTGTCACAAGATCATGACGAAACGCCACACCTTCTTAGCCCACATAAGACAAGTTCACTTCTTTGTGATGAACAAGGAATCTCCCAAGAAGACATATGACTGTCGGATGTGTGACAAGAAGCTTGCCTCGCAGGACTTGCTTATCTCACATCTGGCATCGCATATGTCTCACATGGAAGAGCCTGAGGAAGTTGCTGATGACGATCAAGGGAGCGTGGCCGATGACGCACAATCGATGCAATCGGACTACACCGCCAGCTCGTCATTCTCCAACGGCCCGTACAAGTGTGATATTTGTGACAAAGCCTATAAATACAAGAAGTCATTGGAAAACCACCAGTCCAAGTGCACTGGGGAACCCCAAGCGGAAGGCTTGGTAGAGGTGAAGACGGAACCGCCAGATAAAAAGAATGAAAGTCGCTGCTTCATTTACAGAGACTCTGACGGCGAATACAGTCCGGCCGAGGGAGACGATTTGACGTGCGATATCTGCGAGAAGCAGTTCTCGTACAAGCGCTTGTTGGACCAGCACAAACGAACCAAGCACAATATGAGCTCTGGACATAAACGCGCCAAGATCACGCTCAAGGACTGTATGGTGCGCTGTCTCATCTGCGACGTAGAGATGAAGGTGTCGACGATAAACGAGCACAACCAGAAGCACATAGCGGCGAACATCAAGCCTCGCAACCAGTACACTTGCGGCGAATGCTCGGAGAAGTTCAAGAGCTGCAGCGCGCTCGCTACACACATCAAGCTGGTGCATCGCCTCAAGCAACCGCCCAGGCAAGAGAACGAACAGTTCGAAGGCGCGGATTTGGCGGATTTTTGTGAAGTCGTTGTGACCAAGACGGAACCCCTGGACACGGTCCAGCGTCACAACGGCTGTGTAGAGGTTCCAGTCATCGACGGGCCCTTGGTGGATATGGCCGGCTTCACCTGCCACATCTGCGGGAAGAAGCTCAAGACCCTCATCTCGCTCAAGCGGCACGTCAACTGGCACGCCAACGTCGGTAACAACTTACAGAAGAATATTGAGTGCTTTGTTTGCAAAGAGAAGCTCAAGACCCTCATCTCGCTCAAGCGGCACGTCAACTGGCTCGCCCACGTCGGTAACAACTTGCAGAAGAATATTGAGTGCTTCGTTTGTAAAGAGCATATCTGCGGAAAGAAGCTGAAGAGCCTCATCTCGCTTAAGCGGCATGTCAACTGGCATGGCAACGGGCATGGCAACGTCGGTAACAACTTACAGAAGAATATCGAGTGCTTCATTTGTAAAGAGGTATTCAAGTTCCAATGCCACTACCGGCTCCACATGCGCACCCACTACACGGACCCGGATCTAGACCCTCAACACCTCACCTGCCACATCTGCGGGCGCCGCAGCAAGCACCTTCGCGCCGCGCAGGCGCACATGAACTACCACAAACAGACACGCTTCAAGAACAAGGACTACCAGTGCAGTATATGTAAGCGAATCTTCCAGTATAGAAAGGTTTATCTAGCGCACATGGCGATACATTACAAGCGAGGGGAGGGACAGAACGCGATCGTCGGGGATCGGCCGATTTTGTCCGCGGTTAAGTTGGACGGTACCCATCAGTGTCCGCAGTGTGGGAAGGTTTGCGATTCAGAAAACTCCCTTAAGTGTCATGTCCGGTGGCATTCTTCTAAGTCTTCCTTATTCGGGTCGAGACACGAGTGTAACATATGCGGGTTACAGTTCACCAATAAAAGGCGATTGGAAATACACACGAGAGATCACTACGAGGACGAAAATGGACCTTTTAAGTGCACGATCTGCGGTAAAGGGTACATCGACGAAGATTACTTCCGAAGACACGTCAAAGGGCACAACTTCGACCATCAGAGCCATCAGAAGCGCATTGAGAAGCTAAGGAAGGACAAAGTGAAATGCCCGATCTGTTCTCGTTACTATCCGGATCTTCTCAAACTGATCCGTCACCTAAAGCGAACACACCCAGAGAGCAAGATGATCAAAGAAGACCCGGATGCACCACCACCTAAATACTACAGCTGCAAACTGTGCACTCGAGTATTCCTCACGGAACGCAAACTGAAACACCACGAGAAAGCTCATCTGAGGAAACACGAGTTCTTCAAGTGCAAATTCTGCGGAATCAAGAGCGTTTCCTTACGGAAGCATAGACTCCACGTGAAACAGCGGCACATGACGTCAAATTACTTCGAAAATCCTTTAAAATGCCCGTATTGTACCGAGACTTTCGTGAAAGGTTACAAATTGCATCACCACGTGAGAGACCAACACGGAATTGACGAGACGTGGTTAGCTGACCGCGAGGAGGAGCCCATGGGACCGCTCAAGGAGTTCCAGTGCTCCGTCTGCCTCAAGATCCTCGCCTCCAAAGGCAACTATGAGCGACACATCGACTACCACAACTCCTTACGATGCAACTACTGCTTCGACATCTTCAGCTCGATCAAATTCCTCGAAGGTCATTTGGCTTTCAGTTGCGATAAGAAGAAACTGATTGGCGACACCGAAACTTATCCGAAGAAAGTGAAATGCCATATTTGCTACAAAGCTTTCGCTCTGCAAGTGAAAGTTGACTGTCACTTGCGCACTCAACATGGCATCAAAGTGAACAGAGAGTCGGGAGAGGACAAAGGGGAGCATTTGTGTGACTATTGCTTCAAAGTGTTCGAGAACGGACACGCGCTCGCGATGCACAAGATCTACCACCGCACCATCGGCTACTACGGCTGCATTTACTGCGATAGGAAGTTCAACACGTACCAAATGTTCAACAGACACAAGAAAAACCACTTGTACGTCATGAACCGCGATGATCCGTTTAAATGTGAGCACTGCGACGAGACCTTCGTGGTTTTCAGAGACATGATCGACCACATGAAGGAAGACCACGGAGACGACAAGGACTGGATCGTCAATCCTAAAGAGGTCACCGAAGAGTACTGCGAAATCTGCAAAAAGCCGTTCTTCAACTTGCACAGACATCTCGCGTATCACGAGGAAAATAGGTGTAAGAAATGCGGAGAGTATTTCCTGTCGAGAATAGATTATGACAACCATCTTTGTGCCATAGAGAGCGACGACGAAGTCAAAGAGGGAGACGAGAACGACATTCGGCCTAAATACGAAGAGTGCAAGTTCTGCTTCAAGCCTATAACTAAAAGAGTCACTAAGAAGCTACACGATAGTCTTCATAACATATCCGGGGCGATCTCCTGCCGGTTCTGTAAAGCGAAATTCAAAACTTTAGACGCGTTCAACATCCACGCGTTCTCGCACCGAAGCAGAAAGTACCACCAGAACCCGATCAAGTGCCGAGTGTGCAAAGAAAAGTTCCCGAGATACGGACCGTTCGTCAAACACATGAAAACGGTTCACAAGTCGAAGAAAAAGATGCATTACAAAGCGTTCGTCAAACCGGAGCGTTGCGTTGTGTGCGGAGATTACTTTCCGAACCTACACAACCACTACAGGTGCCATTTACAAAACCAGTGCCTCCAATGCCGCAAGTACTTCAGCTCTGTAAAATTGTTTTCAGAGCATCAATGCGATAAAGAAGACGCCGATCCGTCTAAAGTATTTACAAGCGACGAAGATCTCTATGCACTTATAAAATCTTACGTTCCCAAAGATGAGAAAAACGACGAAAAATTCTATGGTTACACCGATGACGAAGAAGATGAGGAAGAAACACCGAGCGTACCTGAAACACACAACGAGAACAGCCAGAATTCCTTGGAAGACGTAATACAACAACCGTTCGTTATATCCGACGTACTGTCCTTATACGAGAAAAAAGAAGAATTGTTAGCGTCGTACATGCAAGAGGACCCGAAGAAGAAAGAACTGAGTCCTAGAAAGAAGATTAGTCCGAAAAAGAAGAGtcctcaaaaatatgaaaataagaaTGGTGAGGGAAGTTTGGAGAATGGAAATGGCACTaaagatgacgatgatgatgacagcGATGTTGAAGTAGTGATAATGCTAGACGAAGACTCCAACGGCGTTGAGAATAGCAACAATATTATTAGTATTGAtttagatgatgatgacgattga
Protein Sequence
MALKLGKCRLCLKLGDFYSIFTMDNALQLSDMAMDCARIKIYEGDGLPDKICSECVQKLSSAYIFKQQCERSDTELRRNYVPPPGFSVTPPPPNRQSSDSAFSSANTDMSYHKTPSTEKVTPANRARKRSRESVDESVSSRFHDYRPSTSKRVEELRTSNKKPRNLSPNASLDSDYEDTSYFPYSAGTDSDEPLLSHKCKQCSKEFKSSLSLRSHMKVHKEKKSLGTDNAVVNIPRKSLEDAKDSEDKLSCDKCHKTFKLKIMLKRHQETCGKTPQLSKELIISLEPVDAVLTSKQEYSKPVDPSKIVKCEMCDTKFKTYENMEKHMKFAHAAVPKTPKPVQAKVEKINFPCLYCCVPFDEYAAMATHFHDCPKRDDTLPLKCPVCHKIMTKRHTFLAHIRQVHFFVMNKESPKKTYDCRMCDKKLASQDLLISHLASHMSHMEEPEEVADDDQGSVADDAQSMQSDYTASSSFSNGPYKCDICDKAYKYKKSLENHQSKCTGEPQAEGLVEVKTEPPDKKNESRCFIYRDSDGEYSPAEGDDLTCDICEKQFSYKRLLDQHKRTKHNMSSGHKRAKITLKDCMVRCLICDVEMKVSTINEHNQKHIAANIKPRNQYTCGECSEKFKSCSALATHIKLVHRLKQPPRQENEQFEGADLADFCEVVVTKTEPLDTVQRHNGCVEVPVIDGPLVDMAGFTCHICGKKLKTLISLKRHVNWHANVGNNLQKNIECFVCKEKLKTLISLKRHVNWLAHVGNNLQKNIECFVCKEHICGKKLKSLISLKRHVNWHGNGHGNVGNNLQKNIECFICKEVFKFQCHYRLHMRTHYTDPDLDPQHLTCHICGRRSKHLRAAQAHMNYHKQTRFKNKDYQCSICKRIFQYRKVYLAHMAIHYKRGEGQNAIVGDRPILSAVKLDGTHQCPQCGKVCDSENSLKCHVRWHSSKSSLFGSRHECNICGLQFTNKRRLEIHTRDHYEDENGPFKCTICGKGYIDEDYFRRHVKGHNFDHQSHQKRIEKLRKDKVKCPICSRYYPDLLKLIRHLKRTHPESKMIKEDPDAPPPKYYSCKLCTRVFLTERKLKHHEKAHLRKHEFFKCKFCGIKSVSLRKHRLHVKQRHMTSNYFENPLKCPYCTETFVKGYKLHHHVRDQHGIDETWLADREEEPMGPLKEFQCSVCLKILASKGNYERHIDYHNSLRCNYCFDIFSSIKFLEGHLAFSCDKKKLIGDTETYPKKVKCHICYKAFALQVKVDCHLRTQHGIKVNRESGEDKGEHLCDYCFKVFENGHALAMHKIYHRTIGYYGCIYCDRKFNTYQMFNRHKKNHLYVMNRDDPFKCEHCDETFVVFRDMIDHMKEDHGDDKDWIVNPKEVTEEYCEICKKPFFNLHRHLAYHEENRCKKCGEYFLSRIDYDNHLCAIESDDEVKEGDENDIRPKYEECKFCFKPITKRVTKKLHDSLHNISGAISCRFCKAKFKTLDAFNIHAFSHRSRKYHQNPIKCRVCKEKFPRYGPFVKHMKTVHKSKKKMHYKAFVKPERCVVCGDYFPNLHNHYRCHLQNQCLQCRKYFSSVKLFSEHQCDKEDADPSKVFTSDEDLYALIKSYVPKDEKNDEKFYGYTDDEEDEEETPSVPETHNENSQNSLEDVIQQPFVISDVLSLYEKKEELLASYMQEDPKKKELSPRKKISPKKKSPQKYENKNGEGSLENGNGTKDDDDDDSDVEVVIMLDEDSNGVENSNNIISIDLDDDDD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00844664; iTF_01501429;
90% Identity
-
80% Identity
-