Sgig029264.1
Basic Information
- Insect
- Schoenobius gigantellus
- Gene Symbol
- -
- Assembly
- GCA_963935595.1
- Location
- OZ012546.1:13724914-13725462[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 1e-07 7.9e-05 24.7 0.1 25 65 10 51 4 105 0.82
Sequence Information
- Coding Sequence
- ATGGATGCCACAGCTGATGAGGCCGCTCAAGTGGTTGCACTGCTGCAATCAGGGATGCGGCAGTGTGATGTCGCCCGGCAACTGAATCTGAGCCGTTTTTCGGTTCGAAGAGTATACCAGCGCTTTTTAGAGACCGGTGGCTATATCCGGAGACATGGGTCCGGTAGACGTCGCTGCACTTCGGAAAGAGACGACCGGTTCGTTGTGTCGTACTCTTTAAGAAATCGCTTCTCAAACGCTATTCAGTTGCAACAGCAGCTCCAGGCAGCTCTCAGACGCACCGTGAACGTCTCTACGattagaagaagactgaaggagaagaagatagcagcccacagagctgctacaggtccaaaattgactgcagcgcaccggcgagcccgcttacagtttgctcgtgaccacgtcgattggacccttgagcagtggggagctgttctcttctcagacgagacgcgagtgtgtctTTTCTGCAACGACCGACGGAGAAGGGTATACCGGAGGCAGGGTGAACGTTTCGCCCAAGCCTGCATCCAGGAGACGGTGTAA
- Protein Sequence
- MDATADEAAQVVALLQSGMRQCDVARQLNLSRFSVRRVYQRFLETGGYIRRHGSGRRRCTSERDDRFVVSYSLRNRFSNAIQLQQQLQAALRRTVNVSTIRRRLKEKKIAAHRAATGPKLTAAHRRARLQFARDHVDWTLEQWGAVLFSDETRVCLFCNDRRRRVYRRQGERFAQACIQETV
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01020257; iTF_01331521; iTF_01020262; iTF_01020258; iTF_01020259; iTF_01020260; iTF_01020261; iTF_01020263; iTF_01282251; iTF_01282255; iTF_01282256; iTF_01020256; iTF_01331526; iTF_01334822; iTF_01331527; iTF_01331483; iTF_01331549; iTF_01020264; iTF_01020265; iTF_01021198; iTF_01021192; iTF_01282250; iTF_01021201; iTF_01331535; iTF_01021200; iTF_01331514; iTF_01331519;
- 90% Identity
- iTF_01331526; iTF_01334822; iTF_01334827; iTF_01331535; iTF_01331537;
- 80% Identity
- -