Mnit007188.1
Basic Information
- Insect
- Musotima nitidalis
- Gene Symbol
- Tsr1
- Assembly
- GCA_949126915.1
- Location
- OX421419.1:987451-991841[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 8.7e-08 0.00011 23.0 0.1 25 65 10 51 4 105 0.76 2 3 2.3 2.9e+03 -1.0 0.0 49 70 96 117 78 136 0.59 3 3 2.8 3.6e+03 -1.3 0.0 29 68 169 208 138 217 0.69
Sequence Information
- Coding Sequence
- ATGGATACTACAGCTGATGAGGCCGCTCAAGTGGTTGCACTACTGCAAGCAGGGTTGCGGCAGTGTGATGTCGCCCGGCAACTGAATCTGAGCCGTTTTTCGGTTCGAAGAGTCTACCAGCGCTTTTTAGAGACCGGTGGCTATATCCGGCGACATGGGTCCGGTAGACGTCGCTGCACTTCGGAAAGAGACGACCGATTCGTTGTGTCGTACTCTTTGAGAAATCGCTTCTCAAACGCTGTGCAGTTGCAACAGGAGCTCCAGGCAGTTCGCAGACGCACCGTGAGTGTCTCCACGATTAGAAGAAGACTGAAGGAGAAGGACATAGCAGCCCGCAGAGCTGTTACAGGTCCAAAATTGACTGCAGCGCACCTTCGAGCCCGCTTGCAGTTTGCTCGCGACCACGTCGATTGGACCATTGAGCAATGGGGAGCTGTTCTCTTCTCAGACGAGACACGagtgtgtcttttctgcaacGACCGACGAAGAAGAGTATACCGGAGGCAGGGTACCCACGGCCACATGAAGTGCGTGTTCGACGGACAACTCAAATCGCAAGACACTGTGCTGCTGAACCTGTATAAACGCATGTTCCCCAAGTGGACCTATGAGCCCTGCATCGTCACCGACGCCAAGGGAACCGCAGGGGACGATGCGATGGAAGATTGA
- Protein Sequence
- MDTTADEAAQVVALLQAGLRQCDVARQLNLSRFSVRRVYQRFLETGGYIRRHGSGRRRCTSERDDRFVVSYSLRNRFSNAVQLQQELQAVRRRTVSVSTIRRRLKEKDIAARRAVTGPKLTAAHLRARLQFARDHVDWTIEQWGAVLFSDETRVCLFCNDRRRRVYRRQGTHGHMKCVFDGQLKSQDTVLLNLYKRMFPKWTYEPCIVTDAKGTAGDDAMED
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01331534;
- 90% Identity
- iTF_01020264; iTF_01020258; iTF_01020259; iTF_01020260; iTF_01020261; iTF_01020262; iTF_01020263; iTF_01020256;
- 80% Identity
- -