Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.0082 35 4.6 0.1 21 48 199 226 196 230 0.86

2 4 3.5e-05 0.15 12.2 0.0 21 52 227 258 224 259 0.89

3 4 0.096 4.1e+02 1.1 0.1 21 46 255 280 253 283 0.88

4 4 0.00011 0.47 10.6 0.1 21 47 283 309 280 316 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.0082	35	4.6	0.1	21	48	199	226	196	230	0.86
2	4	3.5e-05	0.15	12.2	0.0	21	52	227	258	224	259	0.89
3	4	0.096	4.1e+02	1.1	0.1	21	46	255	280	253	283	0.88
4	4	0.00011	0.47	10.6	0.1	21	47	283	309	280	316	0.88

Coding Sequence: ATGATGCATATCAAGAGCCTGCCGCACGCACATCAGGCCGCAGCGGCAATGAGCAATTGTGACATTGTCATAGTTGCCGCGCAACCGCAAACGActagcgccaacaacaacaacaatgatacTGTTACACAGGCGAGTCATGCCAGCCATGTGGCAGCTGTGGCCCATGCacagctccaacaacaacaacaacaacagcagcagcagcaacaacaacagcagcaacaacagcaacacaatcagcaacaacaacaacagccgccCGCGCCGACAGAAATCGCCTTACCATTTAATATGCATTTGAGCGGAATTTCAGCGGAGGCCCACAGTGCCGCCCAAGCGGCCGCAATGGCAGCTGCGCAGGCCGCGGCAGCACAAGCCGCCGCCGCGGATCAACAGCAAACGGCAGCAACGCAGCcaccaacatcatcatcatcgcatACACTGGCACATCTGGTTGCAAATGCCACACATAGTCCGACAGGGCTTGCGGGTGAATCGCATTACGTCAGCAATGGGCATTCGGGCAATGAGCATTCGGGCGAGGGTAACGGATCGACTGGCagcggtggtggcggtggcggcgggcGGGAACACGAAAAACCGTTCCATTGCACAGTGTGCGATCGGCGATTTCGTCAATTGAGCACACTGACCAATCACGTGAAGATCCATACCGGCGAGAAGCCCTACAAATGCAACGTTTGTGATAAGACGTTCCGTCAATCGTCCACGCTGACGAATCATTTGAAGATTCATACCGGTGAGAAGCCGTACCATTGCAATTACTGTCCCAAGCATTTCCGTCAGCTGAGCACATTGGCCAATCACGTCAAGATTCATACGGGTGAAAAGCCATTCGAATGCGTCATATGCAAGAAACAATTCCGGCAATCGAGTACGCTCAACAATCACATAAAGATCCATGTCATGGACAAGGTATACGTTCCTGTCAAAATCAAAACGGAGGAGGACGAGGGGTGA
Protein Sequence: MMHIKSLPHAHQAAAAMSNCDIVIVAAQPQTTSANNNNNDTVTQASHASHVAAVAHAQLQQQQQQQQQQQQQQQQQQQHNQQQQQQPPAPTEIALPFNMHLSGISAEAHSAAQAAAMAAAQAAAAQAAAADQQQTAATQPPTSSSSHTLAHLVANATHSPTGLAGESHYVSNGHSGNEHSGEGNGSTGSGGGGGGGREHEKPFHCTVCDRRFRQLSTLTNHVKIHTGEKPYKCNVCDKTFRQSSTLTNHLKIHTGEKPYHCNYCPKHFRQLSTLANHVKIHTGEKPFECVICKKQFRQSSTLNNHIKIHVMDKVYVPVKIKTEEDEG

Sequence clustering based on sequence similarity using MMseqs2