Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.006 38 4.6 0.1 21 48 197 224 194 228 0.86

2 4 2.6e-05 0.16 12.2 0.0 21 52 225 256 222 257 0.89

3 4 0.028 1.8e+02 2.4 0.1 21 48 253 280 251 284 0.85

4 4 8.2e-05 0.51 10.6 0.1 21 47 281 307 278 314 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.006	38	4.6	0.1	21	48	197	224	194	228	0.86
2	4	2.6e-05	0.16	12.2	0.0	21	52	225	256	222	257	0.89
3	4	0.028	1.8e+02	2.4	0.1	21	48	253	280	251	284	0.85
4	4	8.2e-05	0.51	10.6	0.1	21	47	281	307	278	314	0.88

Coding Sequence: ATGATGCATATCAAGAGTCTGCCGCACGCACATCAGGCCGCCGCGGCAATGAGCAATTGTGACATTGTCATCGTTGCCGCGCAACCGCAAACGACtagcgccaacaacaacaacaatgatacTGTTACACAGGCGAGCCATGCCAGCCATGTGGCAGCTGTGGCCCATGCACAgctccaacaacagcagcaacaacaacagcaacagcagcaacaacagcagcaacacaatcagcagcaacaacaacaacagccgcccGCGCCAACAGAAATCGCCCTACCCTTTAATATGCATTTGAGCGGAATTTCAGCGGAGGCCCACAGTGCCGCCCAAGCGGCCGCAATGGCAGCTGCGCAGGCCGCGGCAGCACAAGCCGCCGCCacagaacaacagcaatcgGCAGCGCAGCcaccaacatcatcatcatcgcatACGCTGGCACATCTGGTTGCAAATGCCACACATAGTCCGACAGGGCTAGCAGGTGAATCGCACTACGTCAGCAATGGGCATTCGGGCAATGAGCATTCGGGCGAGGGTAATGGATCAActggcagcggcggcggcggcggcggtggcgggcGGGATCATGAGAAACCGTTTCATTGCACAGTGTGCGATCGGCGATTTCGTCAATTGAGCACACTGACCAATCATGTGAAGATCCATACTGGCGAGAAGCCCTACAAATGCAACGTTTGTGATAAGACGTTCCGTCAATCGTCCACGCTGACGAATCATTTGAAAATTCATACCGGTGAAAAGCCGTACAATTGCAACTACTGTCCCAAGCATTTCCGTCAGCTGAGCACATTGGCCAATCACGTCAAGATTCACACGGGTGAAAAGCCGTTCGAATGCGTCATATGCAAGAAACAATTCCGGCAATCGAGTACGCTCAACAATCACATAAAGATCCATGTAATGGACAAGGTCTACGTTCCTGTCAAGATCAAAACGGAGGAGGACGAGGGGTGA
Protein Sequence: MMHIKSLPHAHQAAAAMSNCDIVIVAAQPQTTSANNNNNDTVTQASHASHVAAVAHAQLQQQQQQQQQQQQQQQQHNQQQQQQQPPAPTEIALPFNMHLSGISAEAHSAAQAAAMAAAQAAAAQAAATEQQQSAAQPPTSSSSHTLAHLVANATHSPTGLAGESHYVSNGHSGNEHSGEGNGSTGSGGGGGGGGRDHEKPFHCTVCDRRFRQLSTLTNHVKIHTGEKPYKCNVCDKTFRQSSTLTNHLKIHTGEKPYNCNYCPKHFRQLSTLANHVKIHTGEKPFECVICKKQFRQSSTLNNHIKIHVMDKVYVPVKIKTEEDEG

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00518660;
90% Identity: iTF_01321399; iTF_01328259; iTF_01328099; iTF_01326660; iTF_01326819; iTF_01320845; iTF_01320680; iTF_01325880; iTF_01326050;
80% Identity: iTF_01321399;