Basic Information

Gene Symbol
-
Assembly
GCA_035044645.1
Location
JAWNNT010000127.1:1724509-1727659[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 5.3e-05 0.0035 17.7 4.9 1 23 167 190 167 190 0.97
2 16 0.0026 0.18 12.3 4.1 1 23 235 258 235 258 0.96
3 16 0.00072 0.048 14.1 2.6 1 23 323 346 323 346 0.94
4 16 0.0063 0.42 11.1 0.6 2 23 398 419 397 419 0.96
5 16 8 5.3e+02 1.4 1.9 1 20 532 551 532 553 0.90
6 16 0.025 1.7 9.2 0.6 1 23 562 584 562 584 0.93
7 16 0.00052 0.035 14.5 2.2 1 23 591 613 591 614 0.95
8 16 0.00045 0.03 14.7 1.4 2 23 622 643 621 643 0.96
9 16 0.0027 0.18 12.3 0.1 2 21 670 689 669 693 0.88
10 16 0.11 7.5 7.2 0.9 1 23 732 755 732 755 0.95
11 16 1 69 4.2 3.9 1 22 762 783 762 783 0.96
12 16 9.5e-05 0.0063 16.9 0.8 1 23 792 815 792 815 0.98
13 16 1.6e-05 0.0011 19.3 0.5 1 23 834 857 834 857 0.97
14 16 0.096 6.4 7.4 0.2 1 23 867 889 867 889 0.94
15 16 2.4e-05 0.0016 18.7 3.3 1 23 895 917 895 917 0.99
16 16 5.1e-05 0.0034 17.7 0.9 1 23 923 945 923 945 0.98

Sequence Information

Coding Sequence
ATGACAAGAACGTGCAGAGTCTGCGGTGGTGCAGATGGACGTTTTTGGATCGAGTCGCCCGTTAATAAATTCGcgccaaaaacatttaatcaaCTAGTACTGGAGCTAACAAACCTCGAGGGCTCCCTTGATGAAATTGACAAGATGCCACACTGGATTTGTCGCAACTGTGTACAAAGATTAGAAAATGCCTACGACTTTGTACTGCAAGCGCGTAAAACGTATAAGCTCTGGCTGCAAAAACTGGCAGCACTATCCATTTCAGAGGACACTGAAACGGCGACTTTGGAGTGCTTGCGAGAGACGCCCATACAATTGCTCGAAATAGAGGGCGTCACTATCAAAATGGAGGaggcaacagaaacagccaTACCACCCTTAGATCCAACCAGTACAATTGATCCACTGAACAAGAAAAGTTGTCTGGATGATGATTCTGAAGATGATGATGTCCCGCTCAAGCAGCGTCAAATGGCACATAAAAAACAGCTAACAATGCATCAATGCAACAAGTGCGACAAAGGCTTTAGATATGTAACGAATCTCTTCCGACACAAGCGACGAGATCACAGTCCGGAGCATAGACAAACTAAAGAGCAGACCGAtgaaaagaaaccaaaaacgtTGCTTCGAACTATAATCAAAAGCTCGATTGAAGCACAAAGCAACGTAGATCATGAAAGTGAATCAAGCGATAGCTACTACAAATGCGATCAATGCGACAAGTCCTACAAATACATAATGCTGTTAatcaagcacaagcacaagacACACATTTCCAGCCAGTGGCTAACAGAACATAGACCAATTGGAAGCAGTGGACCAAGTGCAGAAGAGTCACCAAAGCAAGGACTTTTGCGTTACCCCTCAAAAGCATCTAACACAGATTCTCTGGTACATAGCATTATAAAAGAAATCAACTTGCCTGATGAGGACGATGCAGACAACTCAAGTGCAGATAATTACTACAAGTGCGACCAGTGCGACAAATCTTACAAATACATTGTTAGTCTCatcaagcacaagcacaacgTGCACAAAGAGTACAATGATTCTGATGAAGAAGAGGGCGAAGCAACCCCCTCTAGATATGCAGCAGATGCATCTGCGATGTCAAAGCCATCACGCATTGATCGCCGTGTCAAGGGATTTGATTTACATCGCTGTAGGCACAATGGATCTAAGGAAATTCAATGCATGATCTGTTTGCGCAGATTTATCAAATTACGACAACTGCGCGATCATTTAAAAGCACATCCAAAGGACTTTACATTTGAGGCTCATGGTGAGCCAATTGAACGCATTGCAGAGGGATTCTATAAGACAGCCGTAGAGTCCACAGTTGCAGGGCTAAAGCGACGCATCTTCAACGATCTCGAAGTGGGCATGTTTGGACGCTACTACTCCATAACCAATGAGGCACGCTACGAGATGAATCTAGACAGTTCGGACACAGACAGCGACGGCGAAGCAGATGTTGTAAAGCGAAACTCATATGCCTGCGAAATCTGTGATTCGCCCGATGCCGTGTGGCCACGTAAATACCAGTTGCACGAGCATCATCGACAGCAGCACACATGGCTAGAGGCGCCGCATGTCTGTCAACGGTGTGATTCACGTTTCCTCAGTGCTGTACTGCTCGAGCATCATACACACAAACTGTGCCAGAACACGTTAAAACGTTTTATGTGTGATAAGTGTCCGCAGCGATTCTTTTGGCGCCGCAATCTACGCGCACATCTCGTGGATCATAAAAATAAGCAAGAGACATATGCATGTGATCAGTGCTCGCGTAGTTTTCAGGACAAGAGTGCTGTGACTAAGCACAAGCTAATGCATCATGATGTTAGCAACGAGCTCTTACCTTGCCGCTGGTGCACCCGCACTTTTTATCGTCCGGCACTGCTACACAAGCATGTGCAGCGTCATGGCTTTAGTGGTGAGGATCTACCACTGGCAGAGACACTGCTGGCAGATGCTGCCAAACCATCGGGACCTAAAACGATTGTCTGCAAGTTGTGCGACATGCAGTTCGTTAGCATTAGCGATCTGCGGCGACATAACTTAATGCTGGCGCATAGTGATGGGGTTTTGTCGAACTATATGATAAGCACCGAGGACGGCTTTGAACTCCAACTGGACGACACGGATGAGAGTGATGAAGAGCCTACGAGTACAGTAGCCAATAGAACTTATCGATGTGATCTGTGTGAGATGAGCTTCCTGCGCAGGCGCGACATGAGCGAACATCAGTATTCCTTACACACCTTTGACAAGCAGCCACATTCCTGCAATCATTGCATTTTCAAAACAGTTGATAAGACCATGTTGCAGCACCATCTACGCACACAATGTCTTAAcgaggaaaaaaaatacaagtgcTCGCGTTGTGGCTACAAATTTATGTGGCCCGAAAATCTAGAACAACACATGAGGAGCCAGCATCCTAAATCATCTAGTCAAATGCCTGTTGCCACAAAGCGTAGCAGACGTTTTCGTTACCAGTGTCCGCACTGCTGGCGCTCGTTTGTGGTGCAGCCCAGCTTGGACAAGCACATACGTGACATGCATGTCGCAAAGAAGAATCCTGGCAAGAAATATCTCTGCTCCCTGTGCGGCTTGGAATCATTAACGCCCAACAAGCTCAGTATACATATGCGACGTCACAACGGCGAGAAACCATTCAAATGTGATCTCTGCGATATGTCCTTTACCGTGCACTACGAGCTAAAGGTACATCGTCGCAAACACACAGGCGAGCGACCCTACCAGTGTACGTTTTGTGCCAAAGATTTCGCTCGTCCAGATAAGCTACGACGACATGTTTACATGCATAGCGTTAAGCGTTAA
Protein Sequence
MTRTCRVCGGADGRFWIESPVNKFAPKTFNQLVLELTNLEGSLDEIDKMPHWICRNCVQRLENAYDFVLQARKTYKLWLQKLAALSISEDTETATLECLRETPIQLLEIEGVTIKMEEATETAIPPLDPTSTIDPLNKKSCLDDDSEDDDVPLKQRQMAHKKQLTMHQCNKCDKGFRYVTNLFRHKRRDHSPEHRQTKEQTDEKKPKTLLRTIIKSSIEAQSNVDHESESSDSYYKCDQCDKSYKYIMLLIKHKHKTHISSQWLTEHRPIGSSGPSAEESPKQGLLRYPSKASNTDSLVHSIIKEINLPDEDDADNSSADNYYKCDQCDKSYKYIVSLIKHKHNVHKEYNDSDEEEGEATPSRYAADASAMSKPSRIDRRVKGFDLHRCRHNGSKEIQCMICLRRFIKLRQLRDHLKAHPKDFTFEAHGEPIERIAEGFYKTAVESTVAGLKRRIFNDLEVGMFGRYYSITNEARYEMNLDSSDTDSDGEADVVKRNSYACEICDSPDAVWPRKYQLHEHHRQQHTWLEAPHVCQRCDSRFLSAVLLEHHTHKLCQNTLKRFMCDKCPQRFFWRRNLRAHLVDHKNKQETYACDQCSRSFQDKSAVTKHKLMHHDVSNELLPCRWCTRTFYRPALLHKHVQRHGFSGEDLPLAETLLADAAKPSGPKTIVCKLCDMQFVSISDLRRHNLMLAHSDGVLSNYMISTEDGFELQLDDTDESDEEPTSTVANRTYRCDLCEMSFLRRRDMSEHQYSLHTFDKQPHSCNHCIFKTVDKTMLQHHLRTQCLNEEKKYKCSRCGYKFMWPENLEQHMRSQHPKSSSQMPVATKRSRRFRYQCPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLSIHMRRHNGEKPFKCDLCDMSFTVHYELKVHRRKHTGERPYQCTFCAKDFARPDKLRRHVYMHSVKR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00567692;
90% Identity
iTF_01327331;
80% Identity
-