Rpro015392.1
Basic Information
- Insect
- Rhodnius prolixus
- Gene Symbol
- MBD2
- Assembly
- None
- Location
- HiC:14775193-14782616[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 2.3e-11 9.1e-08 31.8 0.1 2 40 4 42 3 90 0.88 2 2 0.0011 4.4 7.2 0.1 28 74 91 145 75 148 0.85
Sequence Information
- Coding Sequence
- ATgtcaattgaaaaaaagaagtatgaaTGTTCCAGTTTACCAAAAGTTTGGCAAAGAGAAGAGGCTATTAGAAAATCTGGTTTTTCTACTGGAAAAATAGATGTTAGCTTTTACAGtCCTGAAGCCCACAGATACGATCCTAAGCCTCACCTTTCTCGACCAGTAGCCGATACGATAGATCTTACAGCTTTTGATTATTCGACTAGCGATTGTAATACACTTCGCAGGCCTAAAAAACCAAGGACCACCCAGTTTGACTACAGTAGTCGAGGGGTAAGAAACGATGCGTCGTTGGTCCCACCAATCAGACAAACTGCTTCTATTTTCAAGCAACCTGTCACAGTTTACAAAACGCAAGAAGGCAAAGTTAAAACTGATTTCAAACATGGCCCTCAAGAAAAACCGAAACagttattTTGGGAAAAACGACTTGAGGGTTTGCGAGCGAGTGATAAAGATGGTTGTGAAGTAGATGCCATGGAATTGCCTAAGTCATTGCGTCCAGTTGGACCTAATGTCGGAGGGGAAACTCTTCTACAATCTGTGGCCACTGCTCTTCATGTACTGTCTCAACCTATTACTGGACAAACAGCATCTAGGGCTGCTCTTTCTAAAGACCCAGGCATATACATCAATCCTGAACAACCATTGGTCCAGGCAATGAACATAAGCGACGAGGATATTCGAAGACAAGAGGAGCGTGTGCAGTTAGCGCGAAGAAGGTTACAAGAAGCGGTGAGAGATCTAGAAGAATCAACTGTAACTACTTAA
- Protein Sequence
- MSIEKKKYECSSLPKVWQREEAIRKSGFSTGKIDVSFYSPEAHRYDPKPHLSRPVADTIDLTAFDYSTSDCNTLRRPKKPRTTQFDYSSRGVRNDASLVPPIRQTASIFKQPVTVYKTQEGKVKTDFKHGPQEKPKQLFWEKRLEGLRASDKDGCEVDAMELPKSLRPVGPNVGGETLLQSVATALHVLSQPITGQTASRAALSKDPGIYINPEQPLVQAMNISDEDIRRQEERVQLARRRLQEAVRDLEESTVTT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01478825;
- 90% Identity
- iTF_01478825;
- 80% Identity
- -