Rlae025686.1
Basic Information
- Insect
- Rhamphomyia laevipes
- Gene Symbol
- MBD2
- Assembly
- GCA_963920725.1
- Location
- OY987257.1:21020391-21021622[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 2.5e-22 1.9e-18 66.9 0.0 2 73 8 74 7 78 0.91 2 2 0.00011 0.84 10.3 0.0 28 73 132 185 115 189 0.82
Sequence Information
- Coding Sequence
- atgaatgccAATATCACTATTGAACGCAGGAAAACGGATTGCACAGCACTTCCCAAAGGATGGCAACGAGAAGAAGTTTTAAGAAAAACGGGGTTATCAGCAGGGAAAATTGATGTTTACTATTACAGTCCATCCGGAAAGAAAATTGAGACAAAACCCCAACTAGCACGCCAATTAGGCGATATCGTAGATATAGCAACTTTTGATTTTGAAAGtggaaaaattattgcaaatgaCGCACAatcttttttatcattaaatcaCCGAAGCTTattaaaacgaaaattattaCCATCAAATATTAGTGGAACTATTGGTACTCATAGCTTTTCCACACCAGGTTTAAGTCCTAATAATCCTTCAGCACTGCGTCGCCAACTTGAATTCAGCCGGGGTATGCGTACTGACATATCTTTAGTTCCACCAATTCGTCAAACAGCATCTATTTTTAAACAGCCAGTAACTGTGGTAAAAAATCAAGAAGGAGGTAAAGTTAAACACGATTCTAAACATGGGCAAGAAAAGCCAAAACAACTCTTTTGGGAAAAACGTTTGGAAGGTTTGAGAGCGTGTAATGTTGCTGGCGAAGagtttgaaaatattgagtTACCTAAGAGTATAAAAGCAGTTGGTCCAAATATATTTCAACAGACAGTTTTGCAATCTATAGCAACTTCACTGCATGTTTCTAATCAACCAGTAACTGGTCAAACAGCTAATTTACAAACTTTACTTTCTAATTCTGGAGCGTACTTAAATCCTGATCAACCTTTAATGCAATCTCTAAATGTAACTGATGAGGATATAAGACGACAAGAAGATCGTGTTGGTACAGCCAGAAGGAGATTACAAGAAGCTCTTAAGGGTTAA
- Protein Sequence
- MNANITIERRKTDCTALPKGWQREEVLRKTGLSAGKIDVYYYSPSGKKIETKPQLARQLGDIVDIATFDFESGKIIANDAQSFLSLNHRSLLKRKLLPSNISGTIGTHSFSTPGLSPNNPSALRRQLEFSRGMRTDISLVPPIRQTASIFKQPVTVVKNQEGGKVKHDSKHGQEKPKQLFWEKRLEGLRACNVAGEEFENIELPKSIKAVGPNIFQQTVLQSIATSLHVSNQPVTGQTANLQTLLSNSGAYLNPDQPLMQSLNVTDEDIRRQEDRVGTARRRLQEALKG
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00643214;
- 90% Identity
- iTF_00644095;
- 80% Identity
- -