Eliv003744.1
Basic Information
- Insect
- Empis livida
- Gene Symbol
- MBD2
- Assembly
- GCA_963932195.1
- Location
- OZ010645.1:51319588-51320889[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 9.2e-22 3.7e-18 65.1 0.0 2 73 8 74 7 78 0.90 2 2 8e-05 0.32 10.8 0.0 28 73 132 197 113 201 0.80
Sequence Information
- Coding Sequence
- atgaacgCTAATATTACTATTGAACGTAGAAAAACAGAATGCAGTGCTTTACCCAAAGGATGGCAGAGAGAAGaagttttaagaaaaactGGCTTATCTGCGGGGAAAATTGATGTTTACTATTATagTCCATCCGGGAAGAAAATTGAGACAAAACCCCAACTAGCACGCCAATTAGGCGATATCGTAGATATAGCAACTTTTGATTTTGaaagtggaaaaattattccaaatgATGCACAATcctttttatcattaaatcaCCGAAGCTTATTAAAACGAAAATTATTACCATCAAATATAAGTGGAACTATTGGCACTCATAGCTATTCCACATCTGGTTTAAGTCCTAATAATCCTTCAGCACTGCGTCGCCAACTTGAATTCAGCCGGGGTATGCGTACTGACATATCATTAGTTCCACCAATCCGACAAACAGcatcaatttttaaacaacCGGTAACTGTTGTCAAAAATCAAGAAGGCGGTAAAGTTAAACATGATTCTAAACATGGACAAGAAAAGCCAaagcaacttttttttaaacatgcACAAGAAAAGCCAAAGCAACTTTTTTGGGAAAAACGTTTAGAAGGTTTGAGAGCGTGTAATGTAGCTGGtgaagaatttgaaaatattgaattgcCAAAGAATATAAAGGCAGTTGGTCCAAACATATATCAACAGACTGTTTTGCAATCTATAGCTACTTCCCTGCATGTTTCTAATCAGCCAGTTACTGGACAAACTGCCAATTTGCAGATTTTACTTTCAAATTCTGGAGCATATTTAAATCCTGAACAACCTTTAATGCAATCTTTAAATGTAACGGATGATGATATAAGACGACAAGAGGATCGCGTAGGTGCAGCTAGAAGGAGATTACAAGAAGCTCTTAAGGGATAA
- Protein Sequence
- MNANITIERRKTECSALPKGWQREEVLRKTGLSAGKIDVYYYSPSGKKIETKPQLARQLGDIVDIATFDFESGKIIPNDAQSFLSLNHRSLLKRKLLPSNISGTIGTHSYSTSGLSPNNPSALRRQLEFSRGMRTDISLVPPIRQTASIFKQPVTVVKNQEGGKVKHDSKHGQEKPKQLFFKHAQEKPKQLFWEKRLEGLRACNVAGEEFENIELPKNIKAVGPNIYQQTVLQSIATSLHVSNQPVTGQTANLQILLSNSGAYLNPEQPLMQSLNVTDDDIRRQEDRVGAARRRLQEALKG
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01297394; iTF_00644095;
- 90% Identity
- iTF_00644095;
- 80% Identity
- -