Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 9.8e-08 0.00017 22.6 0.5 9 47 74 113 68 119 0.85

2 5 0.15 2.6e+02 2.8 0.1 21 44 115 138 110 141 0.86

3 5 0.036 62 4.8 0.0 14 44 136 166 131 174 0.77

4 5 0.14 2.4e+02 2.9 0.1 21 44 171 194 166 204 0.86

5 5 0.019 32 5.7 0.0 26 44 204 222 200 228 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	9.8e-08	0.00017	22.6	0.5	9	47	74	113	68	119	0.85
2	5	0.15	2.6e+02	2.8	0.1	21	44	115	138	110	141	0.86
3	5	0.036	62	4.8	0.0	14	44	136	166	131	174	0.77
4	5	0.14	2.4e+02	2.9	0.1	21	44	171	194	166	204	0.86
5	5	0.019	32	5.7	0.0	26	44	204	222	200	228	0.88

Coding Sequence: ATGAACCAATTAGAGTTAAAAGAAGAAATTCTGGAAGTAGAAATACTGGAATTCCCGGAGAAAGAAGACTTCATGGCAAACACTAATCGAACTCAAGAAGGTTTAAGTTTGGCTGGTACTAAAGAAGACGAAATCGAATCTGATAAACCTCAATGGTCTTTTGCAACCAATAGAGAACCAATAGAAGTCGAAAATTCTGGACAAAAGTTGAACGAAACCACACCTTCCACAAAACCACCAAGAGTGCAGAGCAAAATGGGACAAGAACCTTGCATATGCAAAATTTGTTTCATTACGATATCACATGCGGGTAACTTGAAGAGGCACATGCGATGCCATACGggcgaaaaaccatttataTGCTCAGTTTGTAATAGTAAATTTTCACGTAAGCACCATCTCCAAAAACACATGTCAACTCACACCGGCGAGAGACCATTTTCTTGTGATATTTGCGATTTCACTTCCGTAACAAGAGAAAACTTGAAAACGCACACCAAAACTCACACCGATGAGAAGCCATTTCAGTGCGGAATGTGCGACTACAAGTGCAGGCGAAAGGCTAATATGGATCACCACATTATGGTGAGCCTGAATGTCAAGTTATTTGCATGTAAGATTTGTGATGCATCGTTTTTGCGCAGCTCCAATTTGAAAAGCCATGTTTTAACCCATTCCGAGAAGTGA
Protein Sequence: MNQLELKEEILEVEILEFPEKEDFMANTNRTQEGLSLAGTKEDEIESDKPQWSFATNREPIEVENSGQKLNETTPSTKPPRVQSKMGQEPCICKICFITISHAGNLKRHMRCHTGEKPFICSVCNSKFSRKHHLQKHMSTHTGERPFSCDICDFTSVTRENLKTHTKTHTDEKPFQCGMCDYKCRRKANMDHHIMVSLNVKLFACKICDASFLRSSNLKSHVLTHSEK

Sequence clustering based on sequence similarity using MMseqs2