Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 3.6e-06 0.0016 19.4 0.0 21 47 91 117 78 127 0.87

2 6 0.012 5.6 8.0 0.3 21 43 175 197 172 202 0.90

3 6 0.028 12 6.9 0.1 20 49 202 231 195 234 0.84

4 6 0.051 23 6.0 0.1 21 47 231 257 227 263 0.84

5 6 0.72 3.2e+02 2.4 0.1 21 44 259 282 255 289 0.72

6 6 1.3 6e+02 1.5 0.0 22 44 288 310 284 313 0.70

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	3.6e-06	0.0016	19.4	0.0	21	47	91	117	78	127	0.87
2	6	0.012	5.6	8.0	0.3	21	43	175	197	172	202	0.90
3	6	0.028	12	6.9	0.1	20	49	202	231	195	234	0.84
4	6	0.051	23	6.0	0.1	21	47	231	257	227	263	0.84
5	6	0.72	3.2e+02	2.4	0.1	21	44	259	282	255	289	0.72
6	6	1.3	6e+02	1.5	0.0	22	44	288	310	284	313	0.70

Coding Sequence: ATGGAAGAGTTACAAGATATGGAAAGGATCAAAATAGTTTCAGAAACTCCATATAATTTAAGTAGCAGTTACGAAATTAAGATCGAAGAGGTGGAAGACGTAAAATTTAATTCTGAAGAATTGCACCATTCGATTGACATTAAAGAAGAGTACGAAAATGGACAATCAGGGCAAGACAATAACAAATCGCAAAAATTATTCGAATTTGTAACTTGTGAAAATCGTGCCACACGTACAGACTCATTAAAACGACTCTCAGGTTCAAACACTGATGAAAAACCATTCACTTGCAAAATTTGCGATTATACATATCGGTATAAGGGAAATTTAAAAAGGCATTTGGAAATCCACGCCAGCGAAAAATCGTTTGCGTGTACTGCCTGTGACTACAAATCGGAACATCGAGATGATTTTAGCGAACATTTGAAAATTCATGCTCTCCAAAAGCCATTTTCATGTTCTATTTGCGACTATAAATCGGCTCATAAAAGTCACATGAATGAACATTTGATAATCCATACCGGCGAAAAGCCGTTTTCGTGCAGTATTTGTGACTATAAATGTGCGCAGAAAAGAAATTTGCAAATTCATCGAAAAACTCATACGGGGGAAAAGCCATTTTCCTGTGAGATCTGTGACTATAAATTTCGGCATAAAGGGCATTTGAAAGCCCATTTAAGGATTCACTCCGGTGAAAAACCATTTGCGTGTCATATTTGTGACTATAAGGGTTTGCAAAGAAGAACGTTAAATGAACATTTGAAGACCCACAGTGGTGAAAAGCCCTTTGCGTGTGATATTTGTGACTATCAAAGTGCTCGTAGAGATACCTTGAGACTGCATATAAAAACGCACACCGGCGAAAAAGGCTTTACTTGTGGTATTTGTGACTCCAAATATACTCGTAAATCAAGGCTAAAAGCTCATATAAATACCCATTCTAAATAA
Protein Sequence: MEELQDMERIKIVSETPYNLSSSYEIKIEEVEDVKFNSEELHHSIDIKEEYENGQSGQDNNKSQKLFEFVTCENRATRTDSLKRLSGSNTDEKPFTCKICDYTYRYKGNLKRHLEIHASEKSFACTACDYKSEHRDDFSEHLKIHALQKPFSCSICDYKSAHKSHMNEHLIIHTGEKPFSCSICDYKCAQKRNLQIHRKTHTGEKPFSCEICDYKFRHKGHLKAHLRIHSGEKPFACHICDYKGLQRRTLNEHLKTHSGEKPFACDICDYQSARRDTLRLHIKTHTGEKGFTCGICDSKYTRKSRLKAHINTHSK

Sequence clustering based on sequence similarity using MMseqs2