Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0027 4.7 7.1 0.0 21 43 121 143 117 150 0.89

2 6 0.011 20 5.1 0.1 26 47 154 175 147 182 0.90

3 6 0.00035 0.63 9.9 0.1 25 48 183 206 176 212 0.83

4 6 0.00032 0.57 10.0 0.1 21 45 235 259 228 263 0.89

5 6 0.0062 11 5.9 0.0 21 49 298 326 291 330 0.85

6 6 0.018 32 4.4 0.0 21 45 326 350 322 352 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0027	4.7	7.1	0.0	21	43	121	143	117	150	0.89
2	6	0.011	20	5.1	0.1	26	47	154	175	147	182	0.90
3	6	0.00035	0.63	9.9	0.1	25	48	183	206	176	212	0.83
4	6	0.00032	0.57	10.0	0.1	21	45	235	259	228	263	0.89
5	6	0.0062	11	5.9	0.0	21	49	298	326	291	330	0.85
6	6	0.018	32	4.4	0.0	21	45	326	350	322	352	0.91

Coding Sequence: ATGGAAAAAGATGAAACAAAATCAgttgacgatgatgatgaggtGCAATTAGTTATTCCGGATGATCCTTTGAATGAATGTTTTTTAGATAACTTAGAAAGCAATTTAGTAACAAGTGTTAATGCTGATACCAAGTGTGTTAAACGTAACCGAATTAAGGTTAAAACTGAGTTATCGGTGACGGTGAAGGAACGgagaaatatttacaaatgcTTGGAATGTGACAAAGTGTTTAGTCGTGGTTCGTCATTAGCAATACacagaaaacaacatttacgtaaaaaaatatttaaatgtgatttatgtggtaaaatatttaatcgaaaATCAAGTTTAATAGCGCACACCAAGGTGCACAACGACGAACGTCCGTTTAAGTGTAAATTCTGTTTGCTGACTTTTAGGAAGTCATCGAATCTGTTGAAGCATGAAATCTTTCATACGGGTGACACACGTTTACAGTGTCGGCAGTGTAAAGCTGTGCTGAGTACCGCAGCTAAATTGGAAAAGCATCTTGAAATTCATGAAAAGAGTGCGACTGAGGTGTTCACCTGTGATGCTTGCGGAAAAGTTTTTCGCAAAGCAAGAAACCTGTCGCTGCATATGAGAGTGCACACTGGTTACAAACCGTTCCACTGTCAAATATGCGATAAACATTTCTCACATCGCAGTGTCTATACGATTCATAAGCGAACGCACACCGGAGAACGTCCATTCACCTGTACCGTGTGCAGTAAAAGTTTTCCGCAAAGCTCTAACCTGATCACGCACATGAAAAGTCATGCCACCGAGTTGGGCACCATCGATTCGGTGAAAATTCATTCGTGCCGTCTTTGTGGTAAGTGTTTCTCATATAAAACCCACTTAATACGACACACACGTATTCATACTGGTGAACGACCATTCAAATGCGATATATGCGAGAAATCCTTTACACAATCCGGTTCACTTGTTGAACATATGCGGGTTCACACCGGTGAAAAACCGTACAAATGTACTGTTTGTGGTAAAAACTTTACACAATCCGGTGGTTTAATGCAACACCTGAAAAAACATTAG
Protein Sequence: MEKDETKSVDDDDEVQLVIPDDPLNECFLDNLESNLVTSVNADTKCVKRNRIKVKTELSVTVKERRNIYKCLECDKVFSRGSSLAIHRKQHLRKKIFKCDLCGKIFNRKSSLIAHTKVHNDERPFKCKFCLLTFRKSSNLLKHEIFHTGDTRLQCRQCKAVLSTAAKLEKHLEIHEKSATEVFTCDACGKVFRKARNLSLHMRVHTGYKPFHCQICDKHFSHRSVYTIHKRTHTGERPFTCTVCSKSFPQSSNLITHMKSHATELGTIDSVKIHSCRLCGKCFSYKTHLIRHTRIHTGERPFKCDICEKSFTQSGSLVEHMRVHTGEKPYKCTVCGKNFTQSGGLMQHLKKH

Sequence clustering based on sequence similarity using MMseqs2