Basic Information

Gene Symbol
Aef1
Assembly
GCA_018397935.1
Location
CM031468.1:25087592-25088318[+]

Transcription Factor Domain

TF Family
zf-GAGA
Domain
zf-GAGA domain
PFAM
PF09237
TF Group
Zinc-Coordinating Group
Description
Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.00056 2.7 7.9 0.1 21 51 6 36 3 37 0.87
2 4 6.6e-05 0.32 10.9 0.1 21 51 34 64 31 65 0.87
3 4 0.0029 14 5.6 0.0 21 49 62 90 58 93 0.86
4 4 8.5e-05 0.41 10.5 0.1 21 46 90 115 86 120 0.91

Sequence Information

Coding Sequence
ATGAAATTGCCCAATACTGAAAAGCCATTTCAGTGTAACGTTTGTGAGAAACAGTTCCGTCAATTAAGTACGCTAGCAAACCATATGAAAATTCACACGGGAGAAAAACCATTCAAATGCCATGTGTGCAGTCGAGAATTCAGGCAATCGAGTACCTTAACGAATCACATCAAAATCCATACGGGAGAGAAACCATACAATTGCTCGTTTTGTGGAAAGCAGTTTCGTCAATTAAGTACTTTAAGTAATCATGTCAAAATTCATACAGGTGAGAAGCCATTTGAGTGCGTGGTGTGTAAAAAACAATTTCGACAATCGAGCACGCTCAATAATCATATTAAAATCCATACCGGTGATAAGTTTGTTATCTGA
Protein Sequence
MKLPNTEKPFQCNVCEKQFRQLSTLANHMKIHTGEKPFKCHVCSREFRQSSTLTNHIKIHTGEKPYNCSFCGKQFRQLSTLSNHVKIHTGEKPFECVVCKKQFRQSSTLNNHIKIHTGDKFVI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01257389;
90% Identity
iTF_00347202;
80% Identity
iTF_01257389;