Basic Information

Gene Symbol
KEAP1
Assembly
GCA_963942575.1
Location
OZ012646.1:19794466-19796826[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 7.1e-32 2.4e-29 102.2 0.5 4 109 69 172 66 173 0.95

Sequence Information

Coding Sequence
ATGGATGGAGAAGAAGATTATCAGCAGAAAAAAGGAGCTCAAGGAAGCTTCCAATCACAGAGTCATGAATCAGGATCGCCACTTATTCCCGGGGAGGAGAAGGAGTTTGAGGGTCCGTACAATATGGAAAAAAATGGAGACCTTGGGGACATGACATTTTGCATGGCAAACTATGTCAAAGAAGCTATGAAGATGATGTTCATGATGCGCAGCCATCACATGCTCACTGATGTTATACTCGAAGTAGGATCAGAATTGTTTCATGCGCATAAAGTCATTTTAGCTGCTGCTAGTCCATATTTTAAGGCTATGTTTACTGGAGGCTTAAAGGAATGTGAAATGACAAGAGTAAAGCTTCACGGAGTATGTCCGACTGCCATGGCTCGATTGATGTACTTCATGTACACTGGCCAAATTAGAGTTACCGAAATAACTGTGTGTTCTCTTCTTTCTGCAGCGACTATGTTTCAGGTGAATAATGTCATAGACGCGTGCTGCGTCTTCCTGGAAAGACAGCTGGACCCTACCAATGCCATTGGAATCGCAAATTTTGCTGAGCAACACGGCTGTCACGAATTGTATCACAAAGCCAACCAGTTTATTGTTCAACATTTCAGTCAAATATGCCAGGAGGAAGAGTTCCTCCAGTTATCAGCTATACAATTAGTATCGCTTGTGAGAAAGGATGAACTGAATGTGCAGGAGGAGAGAGAAGTTTacaatgcagttttgaagtggGTAAAGTACAACGAAGAGGCCAGAGGGCCTAAAATGGAGCACATTCTACACGCGGTCCGCTGTCAGTATCTCACGCCAAATTTTCTAAGAGAGCAAATGAAAAATTGCGACGTCCTTAAGAAGGTGCCCGCCTGCCGTGAATATCTTGCGAAGATCTTTAAAGATTTGACCCTGCACAAGAAGCCCGTGGTGAAAGAAAGAACGCCAAATACTCCAAGAGTGATCTACATTGCTGGTGGATTCCTCAAACATTCCTTAGACGTTCTAGAAGGATACAACGCAGACGACAAAACCTGGACGCAACACGCAAAGTTAATCGTTCCGCGGTCGGGCCTCGGTGGAGCGTTTTTGAAAGGGATGTTCTACGCCGTCGGCGGTAGAAATAATTCCCCCGGCAGCAGATATGACAGCGACTGGGTCGATAGATATAATCCTGTGACAGACCAATGGAGACCCTGTAGTCCAATGTCCGTACCAAGGAACCGCGTGGGCGTTGCAGTTATGGACGGATTGTTATACGCCGTCGGCGGTAGTGCGGGTGCTGAGTACCATAACAGTGTCGAATGTTACGATCCGGACCAAGACACCTGGAGTAGCATAAAGTCTATGCATATAAAGAGACTAGGGGTCGGAGTGGCAGTAGTCAACAGATTGCTGTATGCAATCGGTGGTTTTGACGGTACCAATCGACTCAACTCCGTGGAATGCTATCATCCGGAGAATGACGAGTGGACGATGGTTTCACCCATGAAGTGCAGCCGCTCCGGAGCAGGAGTAGCCAGTTTAGGTCAATACATTTATGTAATCGGTGGATACGATGGAACGCGACAATTAAATTCCGTTGAAAGATACGATACAGAACGCGATGTGTGGGAATTCGTAAGCAGCGTCACCATTGCTCGCAGTGCTCTCAGTGTTACGGTACTAGATGGAAAATTGTACGCAATGGGCGGATACGATGGATCAACGTTTTTAAGTATTGTCGAGATTTACGATCCTACAAAAGATCAATGGGAACAAGGAGTGGCCATGACATCAGGCAGGTCTGGTCATGCGAGCGCGGTGTCCTATCATCAGTGTCCCATACATTGCGATCATTTGGATCATAACGCGCCTTTAGACAGGAATCCATCGTGA
Protein Sequence
MDGEEDYQQKKGAQGSFQSQSHESGSPLIPGEEKEFEGPYNMEKNGDLGDMTFCMANYVKEAMKMMFMMRSHHMLTDVILEVGSELFHAHKVILAAASPYFKAMFTGGLKECEMTRVKLHGVCPTAMARLMYFMYTGQIRVTEITVCSLLSAATMFQVNNVIDACCVFLERQLDPTNAIGIANFAEQHGCHELYHKANQFIVQHFSQICQEEEFLQLSAIQLVSLVRKDELNVQEEREVYNAVLKWVKYNEEARGPKMEHILHAVRCQYLTPNFLREQMKNCDVLKKVPACREYLAKIFKDLTLHKKPVVKERTPNTPRVIYIAGGFLKHSLDVLEGYNADDKTWTQHAKLIVPRSGLGGAFLKGMFYAVGGRNNSPGSRYDSDWVDRYNPVTDQWRPCSPMSVPRNRVGVAVMDGLLYAVGGSAGAEYHNSVECYDPDQDTWSSIKSMHIKRLGVGVAVVNRLLYAIGGFDGTNRLNSVECYHPENDEWTMVSPMKCSRSGAGVASLGQYIYVIGGYDGTRQLNSVERYDTERDVWEFVSSVTIARSALSVTVLDGKLYAMGGYDGSTFLSIVEIYDPTKDQWEQGVAMTSGRSGHASAVSYHQCPIHCDHLDHNAPLDRNPS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00773896; iTF_00393675; iTF_01120290; iTF_01270601; iTF_00255171; iTF_01395203; iTF_00252164; iTF_00253671; iTF_01199496; iTF_01474792; iTF_01198762; iTF_00252908; iTF_01474028; iTF_00298419; iTF_00291637; iTF_00294582; iTF_00296119; iTF_00297656; iTF_01473272; iTF_00295354; iTF_00292348; iTF_00770460; iTF_01130909; iTF_00254430; iTF_00293822; iTF_00296894; iTF_00293056; iTF_01475552; iTF_00174404; iTF_00159203; iTF_01414310; iTF_01200295; iTF_00719531; iTF_01411629; iTF_00175154; iTF_00175827; iTF_00060437; iTF_01048309; iTF_01413461; iTF_01412439; iTF_00939706; iTF_00718715; iTF_01303550; iTF_00938848; iTF_01049024; iTF_00761092; iTF_00118084; iTF_00738453; iTF_00963915; iTF_00452653; iTF_00769773; iTF_00687275; iTF_00728732; iTF_00351203; iTF_01273871; iTF_00046258; iTF_00047091; iTF_00048052; iTF_00168599; iTF_00438841; iTF_01273178; iTF_00438173; iTF_01110221; iTF_01112719; iTF_01111060; iTF_01111865; iTF_01254893; iTF_00126821; iTF_00128326; iTF_00129094; iTF_00265100; iTF_00898866; iTF_00127575; iTF_01077559; iTF_00126073; iTF_00264382; iTF_00129856; iTF_01113519; iTF_01099318; iTF_00938104; iTF_00221977; iTF_00218497; iTF_00230753; iTF_01169249; iTF_01228449; iTF_01493665; iTF_01539681; iTF_00215778; iTF_00223266; iTF_00676098; iTF_00963266; iTF_01233730; iTF_01423010; iTF_00141283; iTF_00182691; iTF_00225987; iTF_00684227; iTF_01424451; iTF_01477699; iTF_01070436; iTF_00222597; iTF_00730149; iTF_01266949; iTF_01420997; iTF_01492965; iTF_00141894; iTF_00873862; iTF_00964550; iTF_00625575; iTF_01067015; iTF_01267655; iTF_01422311; iTF_01476999; iTF_00181384; iTF_00228040; iTF_00756744; iTF_01409288; iTF_00016105; iTF_01421641; iTF_01423753; iTF_00087274; iTF_00228746; iTF_00730858; iTF_01523466; iTF_00226667; iTF_00280043; iTF_01354699; iTF_01514891; iTF_00684844; iTF_00961900; iTF_01261900; iTF_01520364; iTF_00220653; iTF_01065645; iTF_01232461; iTF_01476333; iTF_00085486; iTF_00223950; iTF_00229422; iTF_01000654; iTF_01069742; iTF_01405870; iTF_01513550; iTF_01417775; iTF_00088912; iTF_00224624; iTF_00227344; iTF_00391408; iTF_00417680; iTF_01234416; iTF_01271312; iTF_00280657; iTF_00633713; iTF_01068369; iTF_01268369; iTF_01498289; iTF_00016754; iTF_00360978; iTF_00385650; iTF_01090066; iTF_01418418; iTF_00024691; iTF_00140659; iTF_00216467; iTF_00219187; iTF_00306355; iTF_01229107; iTF_01538067; iTF_00233300; iTF_00765748; iTF_01408372; iTF_01514228; iTF_00014805; iTF_00230101; iTF_00215094; iTF_00221334; iTF_00232054; iTF_00962582; iTF_00982358; iTF_01560534; iTF_00088119; iTF_00109911; iTF_01235095; iTF_01269143; iTF_01420343; iTF_00217144; iTF_01069048; iTF_01122520; iTF_01407480; iTF_01419064; iTF_00217817; iTF_00983034; iTF_01355514; iTF_00086395; iTF_00231387; iTF_01269883; iTF_01419707; iTF_00015452; iTF_01123132; iTF_00219869; iTF_00734013; iTF_01066333; iTF_01213405; iTF_01512253; iTF_00142526; iTF_00182046; iTF_00214462; iTF_00885246; iTF_01015934; iTF_01512894; iTF_00232671; iTF_00360287; iTF_01001471; iTF_00084640; iTF_00225312; iTF_00262756; iTF_00051105; iTF_01102914; iTF_00058788; iTF_00398180; iTF_01364740; iTF_00343269; iTF_01215143; iTF_01497545; iTF_01379370; iTF_00652908; iTF_01100716; iTF_00058029; iTF_00829613; iTF_01101453; iTF_00414414; iTF_01103663; iTF_01299377; iTF_00629202; iTF_00059539; iTF_00263604; iTF_00452020; iTF_00798678; iTF_01129430; iTF_00841175; iTF_00265817; iTF_00397401; iTF_00266554; iTF_01508956; iTF_00439581; iTF_01102173; iTF_01306589; iTF_00721343; iTF_00905503; iTF_01207455; iTF_00459872; iTF_00729418; iTF_01245308; iTF_00867530; iTF_00868210; iTF_00868955; iTF_00143952; iTF_01190475; iTF_01233073; iTF_01002175; iTF_01069049; iTF_01067684; iTF_01454266; iTF_01087302; iTF_01489498; iTF_01488790; iTF_01057755; iTF_01056997; iTF_01056159; iTF_00881375; iTF_00882242; iTF_00880579; iTF_00883124; iTF_00997119; iTF_00996433;
90% Identity
iTF_00761092;
80% Identity
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