Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_014622435.1
Location
JACWBX010001155.1:10183-13584[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1e-16 4.5e-13 48.6 0.0 8 74 458 520 454 523 0.94
2 2 1.7 7.2e+03 -3.4 0.0 48 75 986 1012 984 1014 0.80

Sequence Information

Coding Sequence
ATGACATCTAGAAAGTGTATCATTAAAGATTGTGAATCAGAAGACGGTCATGAAGGCATTACATTTCATCGTTTTCCAGGTCCAAAAGGATCTAATGCTGAACACATAAATTTATGGAGAAAAGCTTGCAAAATTGAGAGCGGTTTTAAACCAAACAAGCATCATTTTGTTTGTTCGCAACATTTTCGACGTGAAAACTTTTCAATTCTGAATTCAGGAAAAATAATTTTAAAGCCTCTTACAGTTCCATCGATTTTTCCGTGGAATAAAGATAATATTAAAGTCACAAAATCCACCATCACTATTTCTGACACGGAATCGCCATCAAAGAAGAAAAAAGATGATAAATCGAAAGAAAAGGACACAGAAAAATCAACACCAGAAACAGAAAACAGCAATGCAATTACAGAAAAGAAAGATCCGGAAGGTGATGTTGTTGCATCAACACCAGTTAAAAATGAAGACATAAGTAAAATTGAAAGTCAAAAAAAGAAAAATAGTAATAGTACATTGAAAAAGAAAAACAATTTGGATATAAAAGAAGCATCAACAGCAAAACCAAAAAAATCTTCAAAACGACTTTCTGCAAAATATGAACAAGCATTGATAGAAGCTAAAAAGATTAAATTGGAACAAATTGATACTTCTACCAGTGAAAAAAAAGAATCAAAAATCGTAAAAACTTCAAAAGCGAAGGATGAAATAAAATCCGATACTCCTTCATCACAAACAGTCTCTTCTTCCACTTCTTCATCTTCAATAAAATCAAATGCAATCAGTTTTGTTCCAGGGAACTCTATTGAAGTCAAGAATTTTGATGGAAAATGGGTATCTGTAAAAATTATTGAAGTTGATATGGACGAACGAGAAGTGTTTGTTAAATCGAGTGAAAAGAATAAATCAAAACCAGGATTAAATGATGAATGGATTTCGATGGATAGTCCAAGATTGAGACCAGCACAACCAGCAGTTACTTTCGAGGTTGGCGAAAAAGTTCTAGCAAGATGGAATGATTGCAGAAAATTCTCAGCAACAATTCAGAGAGTGCTTGAGAATGATACATATGACGTTCTTTTTGACGATGGTTATCCAAAAATTGTCCGTGGAGTACACATTCAAAAATTCAATGCGAAAACAGCAGCAAAAACACAAGTAGCAGAAGTTTCTTTGCCACCTACACCAATTAATCCATTGTTACTTAATCCACCGAGCTTGCTTCCTGACTATATAAAAGAAATGAAAGAAGATTTACCAAAACCAATAACAGGTGAAAATGGCGAGTGGTGTTGCGTTTGGGTAGATGATATACCGGTTGGTGAAGAGTCTTCTTTTGATGGCACTTTTGGAAAATGTCCTTCAATCATAATTGCCGATAATCGTCTAAAAGAGGGATGGCAGAAACATATTTATCTGCGTCAAAATGGTAAATGGGATGTACTTTTTATTAGTCCAACAAATCGCAAATTAAGATTCAAGAATGAATTAAAAGTATATCTTGCTGAAACCGGTGAAATTTATGATCCCAATGTATGGGATTTCAGTCTCCATAAAAAACTATCGAAAGCCAAAAATATGTGTATTCAATCTGACAAAATGAAGAAACATCAAGTATTGTCAACATCATTTGATGGCAAGGAATCGGGTGAATCTCCAGTTTTCAATAATCCATTTGCTAATCTCGGTGCATTGCCGTATGTTCAGCCAAATCTCGTTCAAACACCTCCAACACAAAACGAAGTGTCAGTTGGATCACTTAAAGTGAAAGTAATTGATAACAACTATCATTGTCCCGATGAAAAATGTGATAAAACTTTTCGTAAAGAAAATCATTTGCAAATCCACATCAAGCATTATCATGCAGAATTAGCGAAACTTATGGGTGAATGCCCAAACATGGAAGATTTAGCTTATTTGCGAACGACCGTTGATGATACCGAAATAGCAATGGTTAAATCTAATAGAAAGTCTCATGGACCTAAAGAAGGGAAATCTAAATCAAAAATTGACACACAAAATAGCATTCGAGATTTCTCAATTCAAATCGAAAAGTTATCTCCTGATTACAAATTCGATGTTCAAAGATCACCAATTTTAGAGGAAGCATTGAAAGCGCCATTAATCACAACAAATATTCATGCACCAACAAAAGATGATGAGATAAAAAAAGAACTTGTAAATTCACCAATTCAACAATTTGATCCTGAATCATTAATACCTCCGCATGCTGTAAGTCGACCCAATATGAAGTCCCATAAACGTAAAATGAGAATTCGTTTCAATCCAAAGTCAAAAAAATCAAACTTAAAGAAGCGATATGAGTATTATCCAATTAAACAAGATTCAACTGGTTCAACAGTTGAAGGAGTTATACCATATCATGAAGGTCCCTATTTCAAAAATCAACATCCATCAAGCTATGTAGATGAGAATGGTGAAGTTATAAAAATTGTTAGAATGAAAAAGGAAGAAATTATAAATTGCGTTTGTGGCTTTGGTGAAGAAGATGGTCTAATGATTCAATGTGATTTATGTTTGTGTTGGCAGCATGGTATTTGTCACAATATTGAAAAGTCGCATCAAGTTCCAGAGAAGCATGTTTGTTTTATTTGTAAAAATCCTTATAGACAACGTTTGTCCACTAGATTTATGCATGATCAAGATTGGCTCTATGATGGGAAACTTCCAATAGCAAATTATCATGTTGAGAATCCAAAACAGACAGCTCGTTTTGATACACTCAAAGAATGTCATACTCTAATTGGCAATTTGATTGAAATGAAAAAGTTTATGAATAGTTTGGATGTGAAAATCAGCATTGCCGAAAATAGTGAGCATCCAAAATTATATTTGTGGGCAAAAAAATGGGAAGAGAGTTCACCTCGTGAGAAAAGCTCAGATTCTGATTCTAAAGATAACATTAAACTAGATGAAGATGTTAAACTGCCACTTGCTCCTGAACCTGAAGCAGCTATCGAACCGAAAAAATGTCAGCAAACGCTCCTTGATCATATTGAATTTCAACAAAACACTGTTAAATCGCGATTGGATATTATCGAAAATCAAATAACTGCACTTGAAGAAGAAGTTGTAACAAAAATTCCTAATGGAAAGAAATCAATCGACGATGCAACTTTAAAATCAACAATTTATATGCTTATTAAAGATTTAAAACAAATTAATAATTTTGCAGATATCCATCGTAATCCATTACCCGAGGAAGACTTGTAA
Protein Sequence
MTSRKCIIKDCESEDGHEGITFHRFPGPKGSNAEHINLWRKACKIESGFKPNKHHFVCSQHFRRENFSILNSGKIILKPLTVPSIFPWNKDNIKVTKSTITISDTESPSKKKKDDKSKEKDTEKSTPETENSNAITEKKDPEGDVVASTPVKNEDISKIESQKKKNSNSTLKKKNNLDIKEASTAKPKKSSKRLSAKYEQALIEAKKIKLEQIDTSTSEKKESKIVKTSKAKDEIKSDTPSSQTVSSSTSSSSIKSNAISFVPGNSIEVKNFDGKWVSVKIIEVDMDEREVFVKSSEKNKSKPGLNDEWISMDSPRLRPAQPAVTFEVGEKVLARWNDCRKFSATIQRVLENDTYDVLFDDGYPKIVRGVHIQKFNAKTAAKTQVAEVSLPPTPINPLLLNPPSLLPDYIKEMKEDLPKPITGENGEWCCVWVDDIPVGEESSFDGTFGKCPSIIIADNRLKEGWQKHIYLRQNGKWDVLFISPTNRKLRFKNELKVYLAETGEIYDPNVWDFSLHKKLSKAKNMCIQSDKMKKHQVLSTSFDGKESGESPVFNNPFANLGALPYVQPNLVQTPPTQNEVSVGSLKVKVIDNNYHCPDEKCDKTFRKENHLQIHIKHYHAELAKLMGECPNMEDLAYLRTTVDDTEIAMVKSNRKSHGPKEGKSKSKIDTQNSIRDFSIQIEKLSPDYKFDVQRSPILEEALKAPLITTNIHAPTKDDEIKKELVNSPIQQFDPESLIPPHAVSRPNMKSHKRKMRIRFNPKSKKSNLKKRYEYYPIKQDSTGSTVEGVIPYHEGPYFKNQHPSSYVDENGEVIKIVRMKKEEIINCVCGFGEEDGLMIQCDLCLCWQHGICHNIEKSHQVPEKHVCFICKNPYRQRLSTRFMHDQDWLYDGKLPIANYHVENPKQTARFDTLKECHTLIGNLIEMKKFMNSLDVKISIAENSEHPKLYLWAKKWEESSPREKSSDSDSKDNIKLDEDVKLPLAPEPEAAIEPKKCQQTLLDHIEFQQNTVKSRLDIIENQITALEEEVVTKIPNGKKSIDDATLKSTIYMLIKDLKQINNFADIHRNPLPEEDL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_01249156;
80% Identity
iTF_01249156;