Pfla004257.1
Basic Information
- Insect
- Polymixis flavicincta
- Gene Symbol
- -
- Assembly
- GCA_949987655.1
- Location
- OX465172.1:18123032-18123607[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 1.9e-08 9.4e-06 27.0 0.2 25 69 10 55 4 105 0.73
Sequence Information
- Coding Sequence
- ATGGATACCACTGCAGATGAAGCCGCTCAAGTCATTGCACTACTGCAATCAGGGATGCGGCAATGTGATGTTGCTCGGCAACTGAACTTGAGTCGTTTTGCCGTTCGACGAGTGTTCCAACGCTTCCAAGAGACTGGTGGCTATATCCGAAGACGTGGATCTGGAAGACAACGGTGCACATCCGAAAGAGACGATCGCTTCATTGTTTCGACGTCTTTACGTAATCGGTTCTCCAATGCTGTTGAGTTGCAACAACAACTGCGATCAGCTCGCAGAACTTCTGTAAGCGTCTCCACGATTAGAAGAAGAATGCGGGAGAAGAAAATTGCAGCTCATAGGGCTGCCACAGGGCCAAAATTAACTGCACAGCATAGGAGAGACCGGTTGCAATTTGCCcgtgaccatgtggattggacaATAGACCAATGGAGGGCTGTGCTCTTCTCGGATGAGACGAGGGTGTGTCTTTTCTGCAACGACAGGCGTCGAAGAGTGTATAGGAGGCAAGGGGAACGATTCGCGCAAGCCTGTATTCAAGAGACAGTGGAATACGGGGGTGGCTCGTGCATGTTCTAG
- Protein Sequence
- MDTTADEAAQVIALLQSGMRQCDVARQLNLSRFAVRRVFQRFQETGGYIRRRGSGRQRCTSERDDRFIVSTSLRNRFSNAVELQQQLRSARRTSVSVSTIRRRMREKKIAAHRAATGPKLTAQHRRDRLQFARDHVDWTIDQWRAVLFSDETRVCLFCNDRRRRVYRRQGERFAQACIQETVEYGGGSCMF
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00831183;
- 90% Identity
- iTF_00036673; iTF_01246883; iTF_00237545; iTF_00831178; iTF_00831179; iTF_01030188; iTF_00831182; iTF_01527151; iTF_00124242; iTF_01221545; iTF_00300180; iTF_00622804; iTF_00049874; iTF_00036671; iTF_01061844; iTF_01221524; iTF_00374069; iTF_00810037; iTF_01221525; iTF_01441045; iTF_00040790; iTF_00783446; iTF_01085206; iTF_00038743; iTF_01441048; iTF_00172891; iTF_00831196; iTF_00172894; iTF_00831177; iTF_00172895; iTF_00036672; iTF_01221523;
- 80% Identity
- -