Hrec017793.1
Basic Information
- Insect
- Hyppa rectilinea
- Gene Symbol
- -
- Assembly
- GCA_951799385.1
- Location
- OX637315.1:4165220-4165978[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 1.3e-08 1.2e-05 26.2 0.3 25 72 10 56 4 105 0.72
Sequence Information
- Coding Sequence
- ATGGATACCACTGCAGATGAAGCCGCTCAAGTCATTGCACTACTGCAATCAGGGATGCGGCAATGTGATGTTGCTCGGCAACTGAACTTGAGTCGTTTTGCCGTTCGACGAGTGTTCCAACGCTTCCAAGAGACTGGTGGCTATATCCGAAGACGTGGATCTGGAAGACAACGGTGCACATCTGAAAGAGACGATCGCTTCATTGTTTCGACGTCTTTACGTAATCGGTTCTCCAATGCTGTTGAGCTGCAACAACAACTGCGATCAGCTCGCAGAACTTCTGTAAGCGTCTCCACGATTAGAAGAAGAATACGGGAGAAGAAAATTGCAGCTCATAGGGCTGCTACAGGGCCAAAATTGACTGCACAGCATAGGAGAGACCGGTTGCAATTTGCCCGTGACCATGTGGATTGGACAATAGACCAATGGAGGGCTGTGCTCTTCTCGGATGAGACGAGGGTGTGTCTTTTCTGCAACGACAGGCGTCGAAGAGTGTATAGGAGGCAAGGGGAACGATTCGCACAAGCCTGTATTCAAGAGACAGTGGAATACGGGGGTGGCTCGTGCATGTTCTGGGGCGGCATGTCAATCGACGGTAAAACGAACCTTGTGTGTGTTTCTCGGACTGGAAGTGCTCGCGGGCAAGGGTCGCTGACTGCTGCTCGGTACATAACAGAGATCTTCGAGGAGCAGGTTGTCCCTTATGCGGGTTTTGTTGGCAGTGGGTTCACGTTAACGCCCGCTGTCACACCGCTTTAA
- Protein Sequence
- MDTTADEAAQVIALLQSGMRQCDVARQLNLSRFAVRRVFQRFQETGGYIRRRGSGRQRCTSERDDRFIVSTSLRNRFSNAVELQQQLRSARRTSVSVSTIRRRIREKKIAAHRAATGPKLTAQHRRDRLQFARDHVDWTIDQWRAVLFSDETRVCLFCNDRRRRVYRRQGERFAQACIQETVEYGGGSCMFWGGMSIDGKTNLVCVSRTGSARGQGSLTAARYITEIFEEQVVPYAGFVGSGFTLTPAVTPL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00701025; iTF_00701027; iTF_00703912; iTF_00036676; iTF_00036678; iTF_00906121; iTF_01030186; iTF_01030187; iTF_01030189; iTF_00036683; iTF_00036682; iTF_00036684; iTF_00172898; iTF_00172908; iTF_00008975; iTF_01246895; iTF_00831184; iTF_00831185; iTF_00831186; iTF_01246898; iTF_00906116; iTF_01441042; iTF_00038744; iTF_01527155; iTF_00706933; iTF_00036674; iTF_01246888; iTF_01221545; iTF_01157743; iTF_00706931; iTF_01085176; iTF_00831177; iTF_01221525; iTF_01527157; iTF_01527153; iTF_00706934; iTF_00036663; iTF_00036693; iTF_00172920; iTF_00282329; iTF_00446105; iTF_00282364; iTF_01441052; iTF_01076477; iTF_01076468; iTF_00831191; iTF_00172917; iTF_01085186; iTF_01076470; iTF_01076471; iTF_01221533; iTF_01246899; iTF_01221528; iTF_00036669; iTF_01441054; iTF_00172896; iTF_00928675; iTF_00810037; iTF_00850716; iTF_00172926; iTF_00172899; iTF_00374071;
- 90% Identity
- iTF_01246898;
- 80% Identity
- -