Basic Information

Gene Symbol
-
Assembly
GCA_949318255.1
Location
OX439139.1:157451457-157464912[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.052 7.1 8.8 0.7 1 23 1479 1502 1479 1502 0.94
2 12 1.9 2.7e+02 3.8 1.0 1 23 1667 1689 1667 1689 0.93
3 12 0.00073 0.1 14.6 2.8 2 23 1692 1713 1692 1713 0.97
4 12 0.00012 0.017 17.0 0.2 3 23 1721 1741 1719 1741 0.98
5 12 7.2e-06 0.00099 20.9 5.8 2 23 1748 1769 1747 1769 0.97
6 12 8.2 1.1e+03 1.8 0.1 5 23 1782 1800 1781 1800 0.96
7 12 0.035 4.9 9.3 0.1 2 23 1839 1859 1838 1859 0.96
8 12 1.1e-05 0.0016 20.3 0.4 1 19 1865 1883 1865 1887 0.95
9 12 4.9e-06 0.00068 21.4 1.8 1 23 1895 1917 1895 1917 0.99
10 12 0.00017 0.024 16.6 6.5 1 23 1923 1945 1923 1946 0.96
11 12 0.001 0.14 14.1 6.4 1 23 1951 1973 1951 1973 0.99
12 12 0.0028 0.38 12.8 5.8 1 23 1979 2001 1979 2002 0.96

Sequence Information

Coding Sequence
ATGGAGCATAATGATATGCTTTATCACGATAATAACAGCAATATTGTTATACTCTGGATTCCATCACACACCGGGATTCAGGGGAATGAATGTGCAGACAATGCTGCAAGGGGAGCACTAGACTTACCTGTAGTTACTGAGACGCCATGTTTTCCTAAGGCTTTATCAAATCCTTTGAAGGCAATTGTAAGACAACAGAACCCTACGCCTATGCGACCCAAATACAATGAAAACCTTAGCAGAAGTCAATGTATTATGTTGGCGAGATTGAGAGTTGGTAAGGCTGTGTTTAATACCAAGAATTACTATGAACGGACAGATCCACCAAGATGCAACCTTTGCGATGTTTATTTATCTATCACTCACATTTTGGCGGAATGCCCAATATCCAAGATTGACGAATCTTTAGAGAAGATGCTGGATTGTGCGcTTTTCACTTATCAACCGCCAACACATATGCAACATCATCAGAAACCCCCACCGGCCTATGGCACTGCAATTAGTCAAATACGATCTCAACATAATCAAAATAAGCATCAAcaacagaaacatcaacaacagcagcagcaacataaTTTGCAACAACAGCAAACGTTGCAAAATAATATAAGAATTCAAATACCAccgccaccaccaccaccaccaattccaacaacaaaacatacaTATTCGCCAAAAAATAGTGATTTGTCAATTCAAAATCATGCAACAATTTCTAGACATAGTCAGTCCCAacaacatcagcaacaacaCAAGGCATATTTGTCACAACATCTGCAAAACCAGCAGCAGCAAGAACAGGAACAATCGCAAGCAAACACGGAAAATACACACAATTCTAGCAATCACATTCCTAATTCCGAAATGTCAAACAAACCGTTATTAAAGGCAATATCCTCTTCAACATTGCAAAATCCAAATGCGAATGTTCCATCATATCCACAAGTTTCCATTAGTCCATCTGCTGCGTCAGCTTCAATGGCAGCCGTAGCGGCATCAACATTAGGAAGACATACTAACTCACCATTTGCAGCATTATTAGCCGCAGCTGCCGGCACTCCATCGCCTTCGAATCCTTCATCTGTTTTGAGGTATGCAGAGTCACCTGTGGCTCATTATTTAGAACGGGAAAATGGTGATTTTATCGTACAAGAAACTCCGAAGCATATTGTTGAATGTGTAGAAACAGATAATGGTGAATTCTCTGTCATTGAACGTATATACCAATCTCCACCCAGTGTTTTACACATTCATGACGACGATGACGAGGATGATGATGGTGATAACTGTAAAGACCGACCTGAATTAATGGATCAAAATGATAATAAGTCAAAACAGCATGGTGTTGTCGACGGTGAAGGTGCTAAGGTAAAATGTGAATCTGGCGAAAagcaaagtaaaacaaaaatttactccAAAGACGATGAAAAAAATAAGTGCAAAAGGAATACTAAGTCTGATGATGAAAGCTCAGTTGATAAcgatattgttgattttgttagTATATCTAGTGATAGCGGTAACGAAGAGGAAGAATTCATATCCCAagaacgaaaaaaacaaaaaaataccaccgagaaaaacaaaaagaatcaAACAAACGTCACATCCAGACTCTCAATGACATCAACTTCAACGCTACCGACTTTATCGCCTTCACCGCCTACTATAGCCACGTCAGGTGTTGGTTACCAATCATCAACTTCTTCTTCATCAATTTCATTACATACTCCTTCTTTGGCCAACGCAAATTCAATACCAACACAACCAAATTCTACAGTCACCACCCCTACAAACAACAGCAGTGGTCGAAAGAAATCGTCTAAAAACACAATCACAGTTCTAAGCGATGTTCAGTTAAATTTAAACGAATATTTAGATTTGGTAGGAAATATTATTGCTTCGAGTAAAGTAGCGGCACAGCGTAAAACGTTTGCATCTATAGCTCCTATTCCTCTAGTGAAAATCGAAAAAGAAGAGCCCATGGACGAGTACGCAACAACaaacaatacaatttcaaaaacaacaaccactaCAGCACCAACAAACTTTGAAACACCACCAACACCTTTAAAGGCCAACAAACATGAGACTGAAGAAATAACTGATACCCCTAGCAGTAGTAATAGTAGACAAACTACAACTaatcataatataatttttacaaacgaACTAGAACAGGATGAACAAGAAATGAAAAAACCTCAGGTCATCGAAAATACATGCGAAAATGGAACAATTTATTCAGCTGTTTCCAATGCTTCCACAAGCCTAATGACTATAAATTCCAGTCATGTTACCAGTGTTATACGTATGGCAACAACTAGTCAACAACATCAGCACCAAGAGCAACAAGAAGACCAATTGGTTAATTCTTTGGAGACCAACAAAAACTCCTTTGAAGCTGAGGATCTATCACAACCACAACGAAAAATGCAATCTGTTGCAAATTCCAAATTGCTAGGCCACATGCCGTTGACACGCAAAGCTCCCAAAAAACTAGTTATAAAGCCAAAATCTTCAAAGACTGAAGTTTTGTCTACCACTATCCCTGCGAATACAGTAAACCAAAATTCCGTTAACAATGATCAGGAAATGCCTTCTACTTCGACTAAGGCTCGACAAGAATATACGAAACAAACTTCTCTTGAGGTAGAAACACAAAATATCATAGatgtaaaagttaaaaatgagcCAATCACTTATGAAAATCTTCAACCACAAACTCAATATCCGCCAACTACAAATTTTAGTATCTTAGAACAACATCTTAGTTCGAAAGAACCTATTCTTGAGTTTAAAGAGGAAAAACCATGCATTACAGAAGCCAGCGTACCGCCGACGACGATCATTAAGGAGATGAAGGTAGAAAATAATGTTAACGACGATGCACGTGTTCTCTATGATTTTGCAAATTCCAAAAAATCGCAAAATGAAACGCCGACAACTTTTCCATCATCCACATCAGTTTTTTCAAGTAAACAAACTAACGTAGAAATTGCACCAATTGAAGAGCTCCAACAGCAACAACTAAACAAGAATATAAACAATGAAAATGAAACTTCAACCTCTTCATCATCAACATATTCTTCACAATCACCAATGGGTGTTATAATGCCAGCTGAAGAACATAATGAAAGTTCCACTACAAATGCTTCAGCTGCTACAAATGCCCACACTCAACATCAAACGGATCAGGTGTACAccgattttcattttaattatctCTATAATAATAGCGGCAACAATGTCACACCGGTTGCAATTGAACAAGCCGACTtaaaaaatcatcaacaatttacatcattttattcaaattctGGCAACAACAATACAATGCTGCTGGAGGACTCATCATCTAGTAAACACTATGCAGAttatcaacaacaacagcagcataATACACAtcaaccacaacaacaacagcagcatcaGTCTGCTGGAACATCACATCACCAATGgtttaacaataacaactacCAAACATCTGAAACCAATATTACACCAGTCACTTCAAATCTTTCAGTTTCCAACATAAATAACGCCTTATCCGTTGATGGCAGTGGGTCTACTGGTAAATATTTAGACTTAGATTCTTGTAAACGAgagcaaaatattgaaataattgtTGGCGATCGTATAACTGTGCCACCGCCGCCACCGCCATCTTCCTCGACTTCGTGTTCATTTAATGGTACAACCGACAATAGTATGGCCGGTATCTGTTCGACGGCAGCGACCCTGAATATTCGAACCGATGAGAAAATGCCAGCTAAAGGTGAAATTTCTGAACAGGAAAGTAATTGCGATATTGATAACTCATGGAGTCAGCcgatGTATGGCGATATTTCGGCGCGTTTCTTTAAAACTACTTTTCCCGGCATCTTCCCTCAAGACAACGGCTGGAATCACGAGGAATATTTTACTGTACAGGATTTGAGTGCATCAACAACGGCTCAAGCCACTACTAGTGCCAATAATAGATTGAAGagttttgACCCGAGCaatagcagcagcaacaacaacagcaatgtacaaatgccaatattttcccaaaattctaaTGATAATTGTAATATTGATGTAATGCCGTCAACGTCAGCAAAAATACGCAAGAGACGTAAACGTAGTTCTCAAGATGGCAAAACGTCTCAATCAAATGGAAAGCGTATACAGCCAACATCAACAGTTACCTCACAACAAATGCTTATGCAACTTCAAAGTGAGATAACAGGAGCTGAGTTTAGTTTTCAACATCAACAGCTTGAAAATCAGCATcatttacaacaacaacatttgcATCAACCCAGTACATCTACAGCATTTTTGGCAGGACCATCAAGTGTTAGTACTGCTTTTATgatgcaacaacagcagcaacaacaacagcaaccacAACAACatcaaacacaacaaaaacaacgcACAAAAGTTTATGAATGCGGTCATTGTAATGCCAAATATTCCAAACTTAAAGATCGCAATGCTCACATGATTGATGTTCACAATTACATACGACAAAATAGGAGATTAGTATGCCCTACAACAGGACTTGCCACACCTCTAAACAATTCCGAAATGCAAGATGTTGCTCTGCCCACAACAAGCGCTGCTGGTAACAATTTGGTGCCTGCCCTTCAGCAAAATTCTGACTGTGTGGGCGATTTCAAACAGGGCATAGTAAAAATAGAAACTGAAAACCCAACGCAACGCGATTTATTTGGCGTAGAACCGATAAATGCCAATTTAAGTGCTAAAACGGAAATTATGGAGgatgacaaaaaaaatctagcCCTGGTACCCTTGAATGCAGCAAATTCTGAAACAAATACTGAATATGACTCTAAACCACCAACCAATAGTTTGCCATTGTCATTAACAACACCCACCAGTAAATTAACCACACTTTATCGCATGCTGGTATCGTTTAATATGACcacattaaaacaaaaccaaagtCTTTCTGAATTTgatgaaaatcttataaaatcTTCCATATTTTTTTGCTACATCTGTCGGCAGAACTTCAATTCGGTAAAGCTATACGATGCTCACTTGACCGAACACCCAGCCGAATGTTTTACATGTGGCAAAAAATTCCAACGAtggaaaaatttttcattacatttaaaacgTCATTTGGGTTGGAAGGAATTCGGTTGTACGGTATGCGAAAAGAAATTTGTGGTGCGAAGTGCCCTTGTTGAACACATGCGCATGCATTCCGGACTATCACCATTAAAATGTAAAGTTTGTGgaAAGCACTTTAAGCGTTACTCGAATTTGACTCAACATCGCAAGCGGCATACAAAACAATTTGTTCGTAGAAAAGAGTATGTTTGTTATTGTGGAGAAGTTTTACCATCCAAAGCTCGTTTCTTATGGCACAAGGAAACTCATGATTCTAAACCAAAATGTTGTCCACATTGTTGTGATCGTTTCGTGCATGTAAACTCTTTGCGACGACACATACGTCTTGCTCATTCGGATAAATTTGATTATACCGAACCAATGGAGTGTCCTATATGCAAGCAAATATTTGCCAAAGCCTCTATGAAAGCTCACATGGCAACGCATTCCACAGAAACTCAATATGATTGTCCGATTTGCAACAAGTCCTTCTCTACAAAATGGAATCTAAAAATTCATTCTTGGGTACATGCTAATAGAACCGCTAAACCTTTTAAATGTGAACACTGCCCTAAGGCATTTGTGCGCGAAGTTGATTTCAAGAATCACATGAATTCTCACAAACAAATCAAACCGTATACGTGTGAAGTGTGCGGCTGTAAGTTTATACGAAAATATAATTACATGCGGCATAGAAGGGAACATCATGGCAATAAAAAGTATACCTGTGATCTATGTAAAAAGTCGTTCCATCGTCACTACTATCTCATCGAACATAGACGCATACACACTGGCGAACGACCTTTTCAATGTTCGATATGCGGTAAAAGTTCAACAACCAAAACAAATCATAACAAACACTTAAAGATTCATCATTCACGTGATCCCTTTACAGTGGAAGTATAA
Protein Sequence
MEHNDMLYHDNNSNIVILWIPSHTGIQGNECADNAARGALDLPVVTETPCFPKALSNPLKAIVRQQNPTPMRPKYNENLSRSQCIMLARLRVGKAVFNTKNYYERTDPPRCNLCDVYLSITHILAECPISKIDESLEKMLDCALFTYQPPTHMQHHQKPPPAYGTAISQIRSQHNQNKHQQQKHQQQQQQHNLQQQQTLQNNIRIQIPPPPPPPPIPTTKHTYSPKNSDLSIQNHATISRHSQSQQHQQQHKAYLSQHLQNQQQQEQEQSQANTENTHNSSNHIPNSEMSNKPLLKAISSSTLQNPNANVPSYPQVSISPSAASASMAAVAASTLGRHTNSPFAALLAAAAGTPSPSNPSSVLRYAESPVAHYLERENGDFIVQETPKHIVECVETDNGEFSVIERIYQSPPSVLHIHDDDDEDDDGDNCKDRPELMDQNDNKSKQHGVVDGEGAKVKCESGEKQSKTKIYSKDDEKNKCKRNTKSDDESSVDNDIVDFVSISSDSGNEEEEFISQERKKQKNTTEKNKKNQTNVTSRLSMTSTSTLPTLSPSPPTIATSGVGYQSSTSSSSISLHTPSLANANSIPTQPNSTVTTPTNNSSGRKKSSKNTITVLSDVQLNLNEYLDLVGNIIASSKVAAQRKTFASIAPIPLVKIEKEEPMDEYATTNNTISKTTTTTAPTNFETPPTPLKANKHETEEITDTPSSSNSRQTTTNHNIIFTNELEQDEQEMKKPQVIENTCENGTIYSAVSNASTSLMTINSSHVTSVIRMATTSQQHQHQEQQEDQLVNSLETNKNSFEAEDLSQPQRKMQSVANSKLLGHMPLTRKAPKKLVIKPKSSKTEVLSTTIPANTVNQNSVNNDQEMPSTSTKARQEYTKQTSLEVETQNIIDVKVKNEPITYENLQPQTQYPPTTNFSILEQHLSSKEPILEFKEEKPCITEASVPPTTIIKEMKVENNVNDDARVLYDFANSKKSQNETPTTFPSSTSVFSSKQTNVEIAPIEELQQQQLNKNINNENETSTSSSSTYSSQSPMGVIMPAEEHNESSTTNASAATNAHTQHQTDQVYTDFHFNYLYNNSGNNVTPVAIEQADLKNHQQFTSFYSNSGNNNTMLLEDSSSSKHYADYQQQQQHNTHQPQQQQQHQSAGTSHHQWFNNNNYQTSETNITPVTSNLSVSNINNALSVDGSGSTGKYLDLDSCKREQNIEIIVGDRITVPPPPPPSSSTSCSFNGTTDNSMAGICSTAATLNIRTDEKMPAKGEISEQESNCDIDNSWSQPMYGDISARFFKTTFPGIFPQDNGWNHEEYFTVQDLSASTTAQATTSANNRLKSFDPSNSSSNNNSNVQMPIFSQNSNDNCNIDVMPSTSAKIRKRRKRSSQDGKTSQSNGKRIQPTSTVTSQQMLMQLQSEITGAEFSFQHQQLENQHHLQQQHLHQPSTSTAFLAGPSSVSTAFMMQQQQQQQQQPQQHQTQQKQRTKVYECGHCNAKYSKLKDRNAHMIDVHNYIRQNRRLVCPTTGLATPLNNSEMQDVALPTTSAAGNNLVPALQQNSDCVGDFKQGIVKIETENPTQRDLFGVEPINANLSAKTEIMEDDKKNLALVPLNAANSETNTEYDSKPPTNSLPLSLTTPTSKLTTLYRMLVSFNMTTLKQNQSLSEFDENLIKSSIFFCYICRQNFNSVKLYDAHLTEHPAECFTCGKKFQRWKNFSLHLKRHLGWKEFGCTVCEKKFVVRSALVEHMRMHSGLSPLKCKVCGKHFKRYSNLTQHRKRHTKQFVRRKEYVCYCGEVLPSKARFLWHKETHDSKPKCCPHCCDRFVHVNSLRRHIRLAHSDKFDYTEPMECPICKQIFAKASMKAHMATHSTETQYDCPICNKSFSTKWNLKIHSWVHANRTAKPFKCEHCPKAFVREVDFKNHMNSHKQIKPYTCEVCGCKFIRKYNYMRHRREHHGNKKYTCDLCKKSFHRHYYLIEHRRIHTGERPFQCSICGKSSTTKTNHNKHLKIHHSRDPFTVEV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01237074; iTF_01236026;
90% Identity
iTF_01236026;
80% Identity
-